Chlorogenic acid ameliorates obesity by preventing energy balance shift in high‐fat diet induced obese mice

He, Xiaoyun; Zheng, Shujuan; Sheng, Yao; Tong, Miao; Xu, Jia; Xu, Wentao; Huang, Kunlun; Zhao, Changhui

doi:10.1002/jsfa.10675

Cited by 63 publications

(33 citation statements)

References 38 publications

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“…This study shows that CGA could increase the contents of Bifidobacterium and reduced the Escherichia coli in NAFLD mice, suggesting its promoting effect on GLP-1 secretion may be related with its effect on these gut microbiota. Some studies have shown that CGA could increase the diversity of gut microbiota ( Song et al, 2019 ; Yan et al, 2020 ), while others have shown that the CGA treated mice showed similar microbial structure compared to that of the HFD mice ( He et al, 2020 ). Based on these researches and our study, we speculated that CGA could regulate composition of gut microbiota under different pathological conditions as a different way.…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Shi

Zheng

et al. 2021

Front. Pharmacol.

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Our previous studies have shown that chlorogenic acid (CGA) could significantly improve acute and chronic liver injury through antioxidant and anti-inflammatory activities. However, its effect on non-alcoholic fatty liver disease (NAFLD) are not entirely clear. This study aims to explore the effect of CGA on NAFLD induced by high-fat diet (HFD) and whether it regulates the gut microbiota and Glucagon-like peptide-1 (GLP-1). NAFLD mice were established by HFD and treated with or without CGA. Serum transaminase, fasting blood glucose (FBG), blood lipids, insulin, GLP-1 and lipopolysaccharide (LPS) were detected. Liver histology was evaluated with Hematoxylin-eosin staining. Toll like receptor 4 (TLR4) signaling pathway was analyzed with western blot and inflammatory cytokines were detected with real-time PCR. The content of gut microbiota were determined with real-time PCR of the bacterial 16S rRNA gene. Expressions of intestine tight junctional protein were examined with immunohistochemistry. CGA could alleviate HFD-induced hepatic steatosis and inflammation, reduce serum transaminase, FBG and blood lipids, increase insulin sensitivity. CGA also could reverse HFD-induced activation of TLR4 signaling pathway and expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver. Meanwhile, CGA increased the content of Bifidobacterium and reduced the content of Escherichia coli in feces. Furthermore, CGA could increase the expression of tight junction proteins Occludin and zonula occludens-1 (ZO-1) in intestinal tissue. Moreover, CGA could the level of LPS and increased the level of GLP-1 in portal vein. These results indicated that CGA protected against HFD-induced hepatic steatosis and inflammation probably through its anti-inflammatory effects associated with regulation of gut microbiota and an increase of GLP-1 secretion and thus could be used as a potential drug for prevention and treatment of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Shi

Zheng

et al. 2021

Front. Pharmacol.

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“…We administered caffeine and CGA by mixing them in the diet, since it is a commonly used method to administer caffeine and CGA to experimental animals, and the easiest to perform. We applied 0.05% (w/w) of caffeine and 0.1% (w/w) of CGA because they are standard doses with proven positive or negative effects in experimental animals [30,[39][40][41][42][43]. Caffeine inhibited fat accumulation in ICR mice at the same dose and the same method as in the present study [40].…”

Section: Discussionmentioning

confidence: 99%

Effects of Caffeine and Chlorogenic Acid on Nonalcoholic Steatohepatitis in Mice Induced by Choline-Deficient, L-Amino Acid-Defined, High-Fat Diet

et al. 2020

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Several recent experimental studies have investigated the effects of caffeine and chlorogenic acid (CGA), representative ingredients of coffee, on nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). However, the results are conflicting, and their effects are yet to be clarified. In the present study, we examined the effects of caffeine and CGA on choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD)-fed mice, relatively new model mice of NASH. Seven-week-old male C57BL/6J mice were divided into the following groups: Control diet (control), CDAHFD (CDAHFD), CDAHFD supplemented with 0.05% (w/w) caffeine (caffeine), and CDAHFD supplemented with 0.1% (w/w) CGA (CGA). After seven weeks, the mice were killed and serum biochemical, histopathological, and molecular analyses were performed. Serum alanine aminotransferase (ALT) levels were significantly higher in the caffeine and CGA groups than in the CDAHFD group. On image analysis, the prevalence of Oil red O-positive areas (reflecting steatosis) was significantly higher in the caffeine group than in the CDAHFD group, and that of CD45R-positive areas (reflecting lymphocytic infiltration) in the hepatic lobule was significantly higher in the caffeine and CGA groups than in the CDAHFD group. Hepatic expression of interleukin (IL)-6 mRNA was higher in the caffeine and CGA groups than in the CDAHFD group, and the difference was statistically significant for the caffeine group. In conclusion, in the present study, caffeine and CGA significantly worsened the markers of liver cell injury, inflammation, and/or steatosis in NASH lesions in mice.

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“…Similarly, chlorogenic acid (100 or 150 mg/ day) reduced oxidative-induced damage and increased antioxidant protection in the inflamed paw skin, and reduced lipid peroxidation in serum (Mitrea et al, 2020). The effect of chlorogenic acid (100 mg/kg BW for 13 weeks) on energy balance in obese mice has been studied recently (He et al, 2020). This compound reduced food intake, increased body temperature, thermal dissipation, brown adipose tissue activity, and improved glucose tolerance.…”

Section: Chlorogenic Acidmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Chlorogenic acid ameliorates obesity by preventing energy balance shift in high‐fat diet induced obese mice

Cited by 63 publications

References 38 publications

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Effects of Caffeine and Chlorogenic Acid on Nonalcoholic Steatohepatitis in Mice Induced by Choline-Deficient, L-Amino Acid-Defined, High-Fat Diet

Citrus species: Modern functional food and nutraceutical-based product ingredient

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