Chlorogenic Acid and Hydroxynitrobenzaldehyde: New Inhibitors of Hepatic Glucose 6-Phosphatase

Arion, William J.; Canfield, Wesley K.; Ramos, Francis C.; Schindler, Peter W.; Burger, Hans-Joerg; Hemmerle, Horst; Schubert, Gerrit Alexander; Below, Peter; Herling, Andreas W.

doi:10.1006/abbi.1996.9874

Cited by 240 publications

(211 citation statements)

References 37 publications

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“…For instance, chlorogenic acid inhibits glucose transporters (Na þ -dependent glucose transporter) (Kobayashi et al, 2000). Chlorogenic acid also reduces or inhibits glucose-6-phosphatase (Glc-6-phase) hydrolysis, which may reduce plasma glucose output from the liver, leading to reduced plasma glucose concentration (Newgard et al, 1984;Arion et al, 1997). In addition, coffee may also influence the secretion of gastrointestinal peptides such as glucagon-like peptide-1 and gastric inhibitory polypeptide; both of them are known for their glucose-lowering effects (Nauck et al, 1993;Meier et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

Bidel

Silventoinen

et al. 2007

Eur J Clin Nutr

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Objectives: To study the joint association of coffee consumption and serum g-glutamyltransferase (GGT) levels on the risk of developing type II diabetes. Design, setting and subjects: A total of 21 826 Finnish men and women who were 35-74 years of age and without any history of diabetes at baseline (years 1982, 1987, 1992 and 1997) were included in the present analyses. They were prospectively followed up for onset of type II diabetes (n ¼ 862 cases), death or until the end of the year 2002. Coffee consumption, serum GGT and other study parameters were determined at baseline using standardized measurements. Analyses were stratified by the serum GGT level classified into two classes using the 75th sex-specific percentiles as the cut point. Results: Coffee consumption was significantly and inversely associated with incident diabetes among both men and women. Serum GGT modified the association between coffee consumption and incident diabetes. Subjects in the high category of coffee consumption with the GGT level X75th percentile showed a significant inverse association for women, and for both sexes combined. The association was not significant in subjects with the GGT level p75th percentile. There was a significant interaction effect of GGT and coffee consumption on risk of type II diabetes in data of women (P ¼ 0.05) and in both sexes combined (P ¼ 0.02). Conclusions: Habitual coffee consumption is associated with lower incidence of type II diabetes particularly in those with higher baseline serum GGT levels.

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Section: Discussionmentioning

confidence: 99%

Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

Bidel

Silventoinen

et al. 2007

Eur J Clin Nutr

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“…Previous studies have suggested that plasma glucose concentrations are reduced by chlorogenic acid (30,31), which may combine with other antioxidants in coffee to decrease oxidative stress. Antioxidants may improve insulin sensitivity (32,33) and decrease insulin levels in rats (30,34).…”

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confidence: 99%

Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey

Choi

Curhan

2007

Arthritis & Rheumatism

211

122

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Objective. Coffee is one of the most widely consumed beverages in the world and may affect serum uric acid levels and risk of gout via various mechanisms. Our objective was to evaluate the relationship between coffee, tea, and caffeine intake and serum uric acid level in a nationally representative sample of men and women. Methods. Using data from 14,758 participants ages >20 years in the Third National Health and Nutrition Examination Survey (1988 -1994), we examined the relationship between coffee, tea, and caffeine intake and serum uric acid level using linear regression. Additionally, we examined the relationship with hyperuricemia (serum uric acid >7.0 mg/dl among men and >5.7 mg/dl among women) using logistic regression. Intake was assessed by a food frequency questionnaire. Results. Serum uric acid level decreased with increasing coffee intake. After adjusting for age and sex, serum uric acid level associated with coffee intake of 4 to 5 and >6 cups daily was lower than that associated with no intake by 0.26 mg/dl (95% confidence interval [95% CI] 0.11, 0.41) and 0.43 mg/dl (95% CI 0.23, 0.65; P for trend < 0.001), respectively. After adjusting for other covariates, the differences remained significant (P for trend < 0.001). Similarly, there was a modest inverse association between decaffeinated coffee intake and serum uric acid levels (multivariate P for trend 0.035). Total caffeine from coffee and other beverages and tea intake were not associated with serum uric acid levels (multivariate P for trend 0.15). The multivariate odds ratio for hyperuricemia in individuals with coffee intake >6 cups daily compared with those with no coffee use was 0.57 (95% CI 0.35, 0.94; P for trend 0.001). Conclusion. These findings from a nationally representative sample of US adults suggest that coffee consumption is associated with lower serum uric acid level and hyperuricemia frequency, but tea consumption is not. The inverse association with coffee appears to be via components of coffee other than caffeine.

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“…A major advance was derived from the cloning of murine and human glucose-6-phosphatase by Chou and co-workers [20,42] and the finding that the glucose-6-phosphatase gene is normal in patients suffering from glycogen storage disease types 1b and 1c [43]. Progress on a parallel path came with the development of a new class of highly specific high-affinity inhibitors of the glucose-6-phosphatase system that act exclusively on microsomal glucose 6-phosphate transport while leaving the enzymic phosphohydrolase activity unchanged [12][13][14][15][16][17][18]. Thus there now is convincing molecular evidence in favour of the substrate transport model of glucose-6-phosphatase.…”

Section: Discussionmentioning

confidence: 99%

“…The chlorogenic acid analogues had no effect on the glucose-6-phosphatase activity by detergentdisrupted microsomes ; neither did they inhibit the pyrophosphatase activity by untreated microsomes. In terms of the substrate-transport model, the compounds are site-specific inhibitors of T1, the glucose 6-phosphate transporter of liver and renal microsomes [14][15][16] without an effect on the glucose-6-phosphatase enzyme or on T2, the postulated P i \PP i transporter. Detailed kinetic analysis revealed that chlorogenic acid or its high-affinity analogues such as S 3483 or S 5627 are reversible linear competitive inhibitors.…”

Section: Interaction Of the Photoreactive Chlorogenic Acid Derivativementioning

confidence: 99%

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Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling

Kramer¹,

Burger²,

Arion

et al. 1999

Biochemical Journal

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The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key regulatory factor of blood glucose homoeostasis. To identify the glucose 6-phosphate transporter T1, we have performed photoaffinity labelling of human and rat liver microsomes by using the specific photoreactive glucose-6-phosphate translocase inhibitors S 0957 and S 1743. Membrane proteins of molecular mass 70, 55, 33 and 31 kDa were labelled in human microsomes by [$H]S 0957, whereas in rat liver microsomes bands at 95, 70, 57, 54, 50, 41, 33 and 31 kDa were detectable. The photoprobe [$H]S 1743 led to the predominant labelling of a 57 kDa and a 50 kDa protein in the rat. Stripping of microsomes with 0.3 % CHAPS retains the specific binding of T1 inhibitors ; photoaffinity labelling of such CHAPS-

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Chlorogenic Acid and Hydroxynitrobenzaldehyde: New Inhibitors of Hepatic Glucose 6-Phosphatase

Cited by 240 publications

References 37 publications

Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey

Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling

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