Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague–Dawley rats

Xue, Yan; Huang, Fang; Tang, Rongxue; Fan, Qiang; Zhang, Bing; Xu, Zhenjiang; Sun, Xiaoming; Ruan, Zheng

doi:10.1016/j.fct.2019.110751

Cited by 36 publications

(14 citation statements)

References 58 publications

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“…Additionally, HFD-fed rats exhibited fat deposition in the liver and lipid metabolism disorders. CGA intervention improved the negative effects of HFD in rats, which is in line with the results of previous studies [ 12 , 28 , 29 ].…”

Section: Discussionsupporting

confidence: 92%

Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High‐Fat Diet via Gut Microflora Adjustment to Increase Short‐Chain Fatty Acid Accumulation in Rats

Xie

Fei

et al. 2021

Oxidative Medicine and Cellular Longevity

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A high-fat diet (HFD) has been previously associated with the development of diseases such as chronic colitis. While chlorogenic acid (CGA) is known to exhibit potent antioxidant, antibacterial, and anti-inflammatory properties, little is known about its effects on intestinal inflammation. In this study, we investigated the effects of CGA on intestinal inflammation in an HFD-induced obesity rat model and assessed whether these effects were related to changes in gut microbiota composition. This was achieved by examining physiological and biochemical indicators, the liver transcriptome, and the structure of the fecal microflora. CGA treatment significantly reduced HFD-induced internal organ weight gain, promoted colon tissue repair, downregulated the expression of inflammatory cytokines, and promoted the accumulation of the tight junction protein. KEGG enrichment analysis of differentially expressed genes, applied to data from the RNA-seq of rat liver tissue, revealed that CGA treatment significantly affected amino acid and lipid metabolism in the liver. Furthermore, CGA decreased the abundance of bacteria belonging to the genera Blautia, Sutterella, and Akkermansia and increased butyric acid levels, which were positively correlated with the abundance of Ruminococcus (butyric acid producer). Moreover, the beneficial changes observed in the HFD group were not as pronounced as those in the CGA treatment group. In summary, CGA can alleviate colitis in HFD-induced obesity through its anti-inflammatory effects associated with changes in gut microbiota composition and an increase in the production of short-chain fatty acids and thus can be used as a potential drug for the treatment of this pathology.

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Section: Discussionsupporting

confidence: 92%

Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High‐Fat Diet via Gut Microflora Adjustment to Increase Short‐Chain Fatty Acid Accumulation in Rats

Xie

Fei

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…A study showed that CA could attenuate cadmium-induced intestinal injury in Sprague-Dawley rats ( Xue et al., 2019 ). Another study showed that dietary CA supplementation can affect gut morphology in weaned piglets ( Zhang et al., 2018b ); however, whether dietary CA supplementation has the similar effect, such on improving the intestine morphology in chickens, was unknown.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury, oxidative stress, and inflammation in chickens challenged with Clostridium perfringens type A

Zhang

Zhao

et al. 2020

Poultry Science

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The goal of the study was testing the effects of chlorogenic acid ( CA ) supplementation on small intestine healthiness, growth performance, oxidative stress, inflammatory response, and blood biochemical indices in specific-pathogen-free (SPF) chickens after infection with Clostridium perfringens (CP) type A. In this study, 324 1-day-old male SPF chickens were randomly distributed into 6 groups: control group; CA group; CP infection group; CA + CP group; antibiotic group; antibiotic + CP group. All 1-day-old chickens were fed with CA or antibiotic in corresponding treatment group for 13 d. On the 14 d, the chickens in corresponding infection group were challenged with CP type A for 3 d. Samples in each group were collected when the chickens were 17 and 21 d old. This study proves for the first time that CA, a Chinese herbal medicine, can effectively improve growth performance, inhibit small intestine structural damage, improve antioxidant capacity, inhibit damage to ileal mucosal layer construction and tight junctions, inhibit inflammatory cytokines, and ameliorate blood biochemical indices. Therefore, this study provides data for CA being able to effectively alleviate small intestine damage caused by CP type A infection in chickens.

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“…13–15 In animals, previous studies have more focused on the beneficial effects of CGA on intestinal barrier function and inflammatory bowel disease in stressed animals by alleviating inflammation and enhancing antioxidant capacities. 16–21 Comparatively, there have been few reports on the beneficial effects of CGA on meat quality in broilers, 22 especially those subjected to oxidative stress, and the mechanism underlying the action of CGA has not been well explored in the literature.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of chlorogenic acid on the meat quality of oxidatively stressed broilers revealed by integrated metabolomics and antioxidant analysis

Zhang

Zhao

et al. 2022

Food Funct.

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Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague–Dawley rats

Cited by 36 publications

References 58 publications

Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High‐Fat Diet via Gut Microflora Adjustment to Increase Short‐Chain Fatty Acid Accumulation in Rats

Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High‐Fat Diet via Gut Microflora Adjustment to Increase Short‐Chain Fatty Acid Accumulation in Rats

Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury, oxidative stress, and inflammation in chickens challenged with Clostridium perfringens type A

Protective effects of chlorogenic acid on the meat quality of oxidatively stressed broilers revealed by integrated metabolomics and antioxidant analysis

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