Chlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo

Yuan, Yan; Liu, Na; Hou, Ni; Dong, Lei; Li, Jie

doi:10.1016/j.jnutbio.2017.04.007

Cited by 119 publications

(94 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compounds such as phenolic acids 27,28 and caffeine 29 have also been shown to have chemopreventive properties, including in liver carcinogenesis 38 . These compounds have been shown to inhibit the proliferation of HCC cell lines in vitro and suppress the progression of HCC in vivo 30 , while chlorogenic acid has been shown to prevent oxidative damage in hepatocytes 31 . Instant coffee, in comparison with ground and decaffeinated coffee, has been demonstrated to have higher levels of those biochemical compounds 3,4 , which therefore could partly explain the more marked reduced risk of HCC in our study.…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption by type and risk of digestive cancer: a large prospective cohort study

et al. 2019

View full text Add to dashboard Cite

Background Evidence of a protective effect of coffee consumption for liver cancer has been found but inconclusive for other digestive cancers. Few previous studies have investigated coffee type (specifically instant or ground coffee) and few investigated a range of digestive cancer types within the one cohort. We therefore investigated the association between coffee consumption by type with digestive cancers in a large UK population-based cohort. Methods We analysed data from the UK Biobank cohort study using self-reported coffee consumption and cancer-registry recorded incident digestive cancers. Hazard ratios (HRs) and 95% CIs were calculated using Cox regression. Risk of every type of digestive cancer was investigated in association with coffee consumption by dose-response and by coffee type (decaffeinated, instant, ground). Results Over 7.5 years of follow-up, 3,567 developed digestive cancer among 471,851 participants. A marked association was observed for hepatocellular carcinoma by any dose of coffee (HR 0.50, 95% CI 0.29, 0.87) and by instant coffee (HR 0.51, 95% CI 0.28, 0.93). We did not observe significant consistently reduced risks of other individual digestive cancer types amongst coffee drinkers. Conclusion We found some evidence that coffee consumption was inversely associated with hepatocellular carcinoma which was apparent for instant coffee consumption.

show abstract

Section: Discussionmentioning

confidence: 99%

Coffee consumption by type and risk of digestive cancer: a large prospective cohort study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…90 Subsequently, Mori et al assessed the effect of CGA on methylazoxymethanol-induced carcinogenesis in hamsters and found significantly less liver cell foci in CGA-treated hamsters (►Table 3). 91 Decades later, the antimutagenic capacity of CGA was examined again in an in vivo/in vitro study of Yan et al 92 In this study, intraperitoneal CGA administration reduced liver tumor volume and weight in HepG2 xenografts in vivo. The authors found a decreased phosphorylation of ERK1/2, possibly due to reduced mitogen-activated protein kinase activation in vitro.…”

Section: Hepatocellular Carcinomamentioning

confidence: 97%

Potential Mechanisms Underlying the Role of Coffee in Liver Health

2018

View full text Add to dashboard Cite

Coffee, the most consumed hot beverage worldwide, is composed of many substances, of which polyphenols, caffeine, and diterpenoids are well studied. Evidence on potential effects of coffee on human health has been accumulating over the past decades. Specifically, coffee has been postulated to be hepatoprotective in several epidemiological and clinical studies. Several underlying molecular mechanisms as to why coffee influences liver health have been proposed. In this review, the authors summarized the evidence on potential mechanisms by which coffee affects liver steatosis, fibrosis, and hepatic carcinogenesis. The experimental models reviewed almost unanimously supported the theorem that coffee indeed may benefit the liver. Either whole coffee or its specific compounds appeared to decrease fatty acid synthesis (involved in steatogenesis), hepatic stellate activation (involved in fibrogenesis), and hepatic inflammation. Moreover, coffee was found to induce apoptosis and increased hepatic antioxidant capacity, which are involved in carcinogenesis.

show abstract

“…Subsequently, medium containing different concentrations of free polyphenol extract (25, 50, 75, 100, 125, 150, 175, 200, 225, 250 μg/mL) and bound polyphenol extract (10,20,30,40, 50, 60, 70, 80, 90, 100 μg/mL) was added (100 μL/well), followed by incubation at 37°C for another 24 h. The medium was then removed, and the plate was washed with PBS (100 μL/well). Thereafter, 50 μL/well of methylene blue solution (prepared with 0.6% methylene blue, 0.67% glutaraldehyde, and 98% HBSS) was added for staining.…”

Section: Cytotoxicitymentioning

confidence: 99%

“…Catechin showed cellular antioxidant activity [38]. In another side, gallic acid, catechin and chlorogenic acid could inhibit the proliferation of HepG2 cells [39,40,41]. Therefore, it could be inferred that these phenolic compounds identifed in M. conica Pers might be responsible for its bioactive activities.…”

Section: Characterization Of the Phenolic Compoundsmentioning

confidence: 99%

Cellular Antioxidant and Antiproliferative Activities of Morchella conica Pers. Polyphenols in vitro

Xia¹,

Li²,

Tan³

et al. 2017

JFNR

View full text Add to dashboard Cite

This study analyzed the cellular antioxidant and antiproliferative activities, as well as the phenolic composition of three Morchella conica Pers. cultures. Results showed that the free phenolic contents of the three Morchella conica Pers. ranged from 4.928 to 6.157 mg GAE/g DW and their bound phenolic contents ranged from 0.188 to 0.250 mg GAE/g DW. Polyphenols in M. conica Pers. were dominated by phenolic acids, particularly for gallic acid. The free phenolic extracts exhibited higher cellular antioxidant activity than the bound phenolic extracts. Free phenolics in M. conica Pers. cultured from Yunnan China showed the highest antiproliferative activity against HepG 2 cells, whereas bound phenolics in M. conica cultured from Tibet China showed the highest antiproliferative activity. Results confirmed that Morchella conica Pers. (growing in Yunnan China especially) could be a new source of natural antioxidant and a potential inhibitor for the growth of HepG 2 cells.

show abstract

Chlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo

Cited by 119 publications

References 26 publications

Coffee consumption by type and risk of digestive cancer: a large prospective cohort study

Coffee consumption by type and risk of digestive cancer: a large prospective cohort study

Potential Mechanisms Underlying the Role of Coffee in Liver Health

Cellular Antioxidant and Antiproliferative Activities of <i>Morchella conica</i> Pers. Polyphenols <i>in</i> <i>vitro</i>

Contact Info

Product

Resources

About