Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways

Bao, Liping; Li, Jushuang; Zha, Dongqing; Zhou, Lian; Gao, Ping; Yao, Tao; Wu, Xiaoyan

doi:10.1016/j.intimp.2017.11.021

Cited by 245 publications

(145 citation statements)

References 28 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…A previous study in piglets also showed that the activity of antioxidative enzymes is enhanced by increasing the mRNA expression level of Nrf2 [36]. Moreover, Nrf2 regulates the activity of HO-1, an important antioxidative enzyme regulating the ROS levels of cells [19] and serving as a sensitive and reliable indicator of cellular oxidative stress [37]. Therefore, R1 and R2 diets enhanced the antioxidative capacity of offspring through upregulating Nrf2 and HO-1 mRNA expression and improving the antioxidant enzyme activity.…”

Section: Discussionmentioning

confidence: 93%

“…The inflammatory response is often accompanied by changes in oxidative stress, which are strongly linked to alterations in the gut microbiota [16,17]. HO-1, an important antioxidative enzyme regulating the ROS levels of cells, can be induced by enteric microbiota [18,19]. However, whether dietary fiber in gestation can change the composition of the gut microbiota and subsequently improve the antioxidative capacity and immune status of offspring by altering the maternal gut microbiota has not been reported.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

Liu

Zhang

et al. 2019

IJMS

View full text Add to dashboard Cite

To study the effects of maternal dietary fiber composition during gestation on offspring antioxidant capacity, inflammation, and gut microbiota composition, we randomly assigned 64 gilts to four treatments and administered diets with an insoluble/soluble fiber ratio of 3.89 (R1), 5.59 (R2), 9.12 (R3), and 12.81 (R4). Sow samples (blood and feces at gestation 110) and neonatal samples (blood, liver, and colonic contents) were collected. The results showed that sows and piglets in R1 and R2 had higher antioxidant enzyme activity and lower pro-inflammatory factor levels than those in R3 and R4. Moreover, piglets in R1 and R2 had higher liver mRNA expression of Nrf2 and HO-1 and lower NF-κB than piglets in R4. Interestingly, maternal fiber composition not only affected the production of short-chain fatty acids (SCFAs) in sow feces but also influenced the concentrations of SCFAs in the neonatal colon. Results of high-throughput sequencing showed that piglets as well as sows in R1 and R2 had microbial community structures distinct from those in R3 and R4. Therefore, the composition of dietary fiber in pregnancy diet had an important role in improving antioxidant capacity and decreasing inflammatory response of mothers and their offspring through modulating the composition of gut microbiota.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

Liu

Zhang

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…This may be due to low concentration of PM2.5-induced ROS generation activating the self-protection mechanism in normal human melanocytes, while in vitiligo melanocytes the Nrf2 pathway can be some kind of dysfunction (17). The Nrf2 translocation could upregulate the expression of antioxidant genes, such as HO-1 (36). Western blot analysis demonstrated that PM2.5 exposure significantly increased the protein expression level of HO-1 in human melanocytes, and pre-incubation of ZnPP exacerbated the oxidative stress response, while hemin pre-incubation reversed the PM2.5-induced oxidative stress injury and cell death.…”

Section: Discussionmentioning

confidence: 99%

PM2.5 induces apoptosis, oxidative stress injury and melanin metabolic disorder in human melanocytes

et al. 2020

View full text Add to dashboard Cite

Recent growing evidence suggested that particulate matter 2.5 (PM2.5) has strong toxic effects on skin systems. However, the possible effects and the mechanisms of PM2.5 on vitiligo remain poorly understood. Therefore, the present study aimed to further investigate the effects and possible mechanisms of PM2.5 on vitiligo. Human keratinocytes (HaCaT cells) and human melanocytes (PIG1 cells and PIG3V cells) were exposed to PM2.5 (0-200 µg/ml) for 24 h. The cell viability of the three cell lines was measured by a Cell Counting Kit-8 assay. The secretions of stem cell factor (SCF) and basic fibroblast growth factor (bFGF) in HaCaT cells were evaluated by ELISA. The melanin contents, cellular tyrosinase activity, apoptosis, cell migration, malondialdehyde (MDA) contents, superoxide dismutase (SOD) levels, glutathione peroxidase (GSH-Px) levels and related protein expressions in PIG1 cells and PIG3V cells were evaluated by a NaOH assay, DOPA assay, Annexin V-FITC/Propidium Iodide staining, MDA assay, SOD assay, GSH-Px assay and western blotting, respectively. It was demonstrated that PM2.5 exposure inhibited cell viability of all three cell lines (HaCaT, PIG1 and PIG3V cells). PM2.5 exposure attenuated the secretions of SCF and bFGF in HaCaT cells. Moreover, PM2.5 exposure attenuated the activation of tyrosinase and melanogenesis, inhibited cell migration, and induced apoptosis and oxidative stress injury in PIG1 cells and PIG3V cells. In addition, PM2.5 exposure caused upregulated cytosolic cytochrome C and activated caspase-3 in PIG1 cells and PIG3V cells. Furthermore, PM2.5 exposure activated the nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 signaling pathway. The present results suggested that PM2.5 exposure could inhibit the secretions of SCF and bFGF in keratinocytes, and cause oxidative stress injury and melanin metabolic disorder in melanocytes. Therefore, PM2.5 could be a new risk factor for vitiligo. PM2.5 induces apoptosis, oxidative stress injury and melanin metabolic disorder in human melanocytes

show abstract

“…25 CGA'nın diyabetik nefropatiye karşı antioksidan özelliği ile renoprotektif etkisi gösterilmiştir. 26 CGA'nın fare makrofaj hücre hattında (RAW264.7)…”

Section: Tas Reaktif Oksijen Türlerini Temiz-unclassified

Deneysel Renal İskemi Reperfüzyon Modelinde Akciğer Dokusunda Oksidan Hasarın İncelenmesi ve Klorojenik Asit (CGA) Kullanımının Koruyucu Etkileri

Güzel

Tanyeli²

2018

Sakarya Medical Journal

View full text Add to dashboard Cite

show abstract

Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways

Cited by 245 publications

References 28 publications

Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

PM2.5 induces apoptosis, oxidative stress injury and melanin metabolic disorder in human melanocytes

Deneysel Renal İskemi Reperfüzyon Modelinde Akciğer Dokusunda Oksidan Hasarın İncelenmesi ve Klorojenik Asit (CGA) Kullanımının Koruyucu Etkileri

Contact Info

Product

Resources

About