Chlorogenic acid protects <scp>d</scp>-galactose-induced liver and kidney injury via antioxidation and anti-inflammation effects in mice

Feng, Yan; Yu, Yinghua; Wang, Zhen; Ren, Jing; Camer, Danielle; Hua, Yu-Zhou; Zhang, Qian; Huang, Jie; Dong, Xue; Zhang, Xiaofei; Huang, Xu‐Feng; Liu, Yi

doi:10.3109/13880209.2015.1093510

Cited by 112 publications

(77 citation statements)

References 33 publications

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“…Oxidative stress and inflammation in vivo such as in hepatic and renal injuries are implicated (Feng et al . ). In addition, the antiodxidant capacity is known to be affected in atherosclerotic cardiovascular disease (Damgaard et al .…”

Section: Resultsmentioning

confidence: 97%

Hypolipidemic and anti‐inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model

Чернуха

Fedulova

Kotenkova

et al. 2018

Animal Science Journal

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The aim of this study was to investigate the effects of aorta and heart tissues obtained from cattle and pigs on atherosclerosis disorders. Atherosclerosis model rats were provided with the respective diets consisting of aorta and heart tissues. Administration of each tissue suppressed body weight gain as compared to that of the control. In particular, the aorta tissues of pigs and cattle demonstrated significant suppressions in body weight gain in the model rats. The aorta tissues of pigs and cattle showed a significant increase and decrease in the serum high-density lipoproteins and atherogenic index, respectively, which was correlated with the increase in apolipoprotein A1. Hematological analysis revealed that aorta tissues of pigs and cattle clearly reduced the ratio of granulocytes/lymphocytes in the atherosclerosis rats. Serum vascular cellular adhesion molecule-1 levels in the atherosclerosis rats, which were administered these aorta tissues, were also significantly reduced. Additionally, there was an increase in von Willebrand factor in the rat serum. Based on the results obtained, the aorta tissues of pigs and cattle, in particular, demonstrated positive effects in the atherosclerosis rats due to the alteration of lipid metabolism and reduction in inflammation related to atherosclerosis.

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Section: Resultsmentioning

confidence: 97%

Hypolipidemic and anti‐inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model

Чернуха

Fedulova

Kotenkova

et al. 2018

Animal Science Journal

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“…SOD protects the cells from damage caused by oxidation, indirectly reflecting their antioxidant activity (Feng et al, 2016). SOD protects the cells from damage caused by oxidation, indirectly reflecting their antioxidant activity (Feng et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum KSFY06 on d‐galactose‐induced oxidation and aging in Kunming mice

Huang

Tan

et al. 2019

Food Science & Nutrition

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Yogurt from Xinjiang, China, is a traditional Chinese fermented food rich in beneficial microorganisms, such as Lactobacillus plantarum KSFY06. In this study, the effect of KSFY06 on oxidative aging was investigated using live animal experiments. Molecular biological methods were used to analyze the serum and tissues of mice with oxidative aging induced by d-galactose, which showed that KSFY06 can inhibit the decline of heart, liver, spleen, and kidney caused by aging. The KSFY06 strain increased the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and glutathione (GSH) in serum and liver of aging mice, while the content of malondialdehyde (MDA) is reduced. Pathological observation showed that KSFY06 alleviated damage to the liver, spleen, and skin of oxidative aging mice. qPCR showed that, at high dose (2 × 10 9 cfu/kg per day), KSFY06 upregulates copper/zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), catalase (CAT) mRNA expression, and its downstream inducible nitric oxide synthase (iNOS) mRNA expression in liver and spleen tissues induced by d-gal. To a certain extent, these findings indicate that L. plantarum KSFY06 is able to protect against oxidative stress in the dgal-induced aging model. In conclusion, L. plantarum KSFY06 may provide a potential research value in the prevention or alleviation of related diseases caused by oxidative stress. K E Y W O R D Saging, Lactobacillus plantarum KSFY06, mice, oxidation

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“…Dietary polyphenols are found in fruits, tea, vegetables, and wine, and are mostly derivatives and isomers of flavonols, catechins and phenolic acid [1]. Polyphenols are documented to have multiple properties including antioxidant [2], anti-inflammatory [3, 4], anti-atherosclerosis [5] and anti-cancer activities [6–8]. …”

Section: Introductionmentioning

confidence: 99%

Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells

et al. 2017

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Trans-Scirpusin A (TSA) is a resveratrol oligomer found in Borassus flabellifer L. We found that TSA inhibited the growth of colorectal cancer Her2/CT26 cells in vivo in mice. Although some cytotoxic T lymphocytes (CTLs) were induced against the tumor-associated antigen Her2, TSA treatment did not significantly increase the level of Her2-specific CTL response compared to that with vehicle treatment. However, there was a significant increase in the level of TNF-α mRNA in tumor tissue and Her2-specific Ab (antibody) production. More importantly, we found that TSA overcomes the tumor-associated immunosuppressive microenvironment by reducing the number of CD25+FoxP3+ regulatory T cells and myeloid-derived suppressor cells (MDSCs). We detected the induction of autophagy in TSA-treated Her2/CT26 cells, based on the increased level of the mammalian autophagy protein LC3 puncta, and increased conversion of LC3-I to LC3-II. Further, TSA induced 5' AMP-activated protein kinase (p-AMPK) (T172) and inhibited mammalian target of rapamycin complex 1 (mTORC1) activity as estimated by phosphorylated ribosomal protein S6 kinase beta-1 (p-p70S6K) levels, thereby suggesting that TSA-mediated AMPK activation and inhibition of mTORC1 pathway might be associated with autophagy induction. TSA also induced apoptosis of Her2/CT26 cells, as inferred by the increased sub-G1 mitotic phases in these cells, Annexin V/PI-double positive results, and TUNEL-positive cells. Finally, we found that the combined treatment of mice with docetaxel and TSA successfully inhibited tumor growth to a greater extent than docetaxel alone. Therefore, we propose the use of TSA for supplementary anticancer therapy to support anti-neoplastic drugs, such as docetaxel, by inducing apoptosis in cancer cells and resulting in the induction of neighborhood anti-cancer immunity.

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Chlorogenic acid protects d-galactose-induced liver and kidney injury via antioxidation and anti-inflammation effects in mice

Cited by 112 publications

References 33 publications

Hypolipidemic and anti‐inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model

Hypolipidemic and anti‐inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model

Lactobacillus plantarum KSFY06 on d‐galactose‐induced oxidation and aging in Kunming mice

Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells

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