Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration

Fang, Jiaqi; Jin, Xuehan; Xu, Bo; Nan, Liping; Liu, Shuhao; Wang, Jianguang; Niu, Na; Wu, Zhong; Chen, Feng; Liu, Junjian

doi:10.1039/d3bm00920c

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Based on the screening results of CCK‐8 to determine the viability of cells in vitro at different concentrations, we opted for 50 µM fisetin due to its pronounced capacity to augment the proliferation of Schwann cells (RSC), which was also utilized in previous research reports. [ 52 ] We assessed the cytotoxicity of FIS at varying concentrations (0, 25, 50, 100, 200, and 400 µM) on RSC 96 cells. As illustrated in Figure 3a,b, the cell viability of RSC improved in the 0–50 µM range compared with those not exposed to the drug.…”

Section: Discussionmentioning

confidence: 99%

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Fang,

Xu,

Jin

et al. 2024

Macromolecular Bioscience

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Peripheral nerve injuries represent a prevalent and severe category of damage resulting from traumatic incidents. Predominantly, the deficiency in nerve regeneration can be ascribed to enduring inflammatory reactions, hence imposing substantial clinical implications for patients. Fisetin, a flavonoid derived from plants, is naturally present in an array of vegetables and fruits, including strawberries, apples, onions, and cucumbers. It exhibits immunomodulatory properties through the reduction of inflammation and oxidative stress. In the present research, a nerve defect was addressed for the first time utilizing a scaffold primed for controlled fisetin release. In this regard, fisetin‐loaded chitosan hydrogels were incorporated into the lumen of polycaprolactone (PCL) nerve guide conduits (NGCs). The hydrogel maintained a steady release of an appropriate fisetin dosage. The study outcomes indicated that the fisetin/chitosan/polycaprolactone (FIS/CS/PCL) NGCs amplified Schwann cell proliferation and neural expression, curtailed oxidative stress, alleviated inflammation, and improved functions, electrophysiological properties, and morphology. This pioneering scaffold has potential to contribute significantly to the field of neuroengineering.This article is protected by copyright. All rights reserved

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Section: Discussionmentioning

confidence: 99%

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Fang,

Xu,

Jin

et al. 2024

Macromolecular Bioscience

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“…PCL conduit with integrated chlorogenic acidreleasing GMs [141], Tuned GelMA hydrogel [142], GelMA/self-assembling peptide amphiphiles carrying a laminin-sourced neuro-inductive epitope [143], Schwann cell-incorporated GelMA having PC-12 cells on the surface [144], Ferrostatin-1-incorporated GelMA [145], Reduced GO/GelMA [146], GelMA-bFGF hydrogels comprising dental pulp stem cellsloaded in cellulose/soy protein isolate nerve guidance conduit [147], PC-12 incorporated GO/GelMA [148], BMSCs-incorporated inner layer of hydrogel and an outer layer of GelMA/PEGDA [149], imidazole-functionalized GelMA hydrogel incorporated with polydopamine@stromal-cell derived factor-1 NPs and human amniotic mesenchymal stromal cells [150], GelMA/super-aligned sheets of carbon nanotubes [151] are some of the latest investigations which showed promising outcomes in nerve repair.…”

Section: Neural Tissue Engineeringmentioning

confidence: 99%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile biomaterials in the biomedical domain. GelMA hydrogels emulate vital characteristics of the innate extracellular matrix (ECM) by integrating cell-adhering and matrix metalloproteinase-responsive peptide motifs. These features enable cellular proliferation and spreading within GelMA-based hydrogel scaffolds. Moreover, GelMA displays flexibility in processing, as it experiences crosslinking when exposed to light irradiation, supporting the development of hydrogels with adjustable mechanical characteristics. The drug delivery landscape has been reshaped by GelMA hydrogels, offering a favorable platform for the controlled and sustained release of therapeutic actives. The tunable physicochemical characteristics of GelMA enable precise modulation of the kinetics of drug release, ensuring optimal therapeutic effectiveness. In tissue engineering, GelMA hydrogels perform an essential role in the design of the scaffold, providing a biomimetic environment conducive to cell adhesion, proliferation, and differentiation. Incorporating GelMA in three-dimensional printing further improves its applicability in drug delivery and developing complicated tissue constructs with spatial precision. Wound healing applications showcase GelMA hydrogels as bioactive dressings, fostering a conducive microenvironment for tissue regeneration. The inherent biocompatibility and tunable mechanical characteristics of GelMA provide its efficiency in the closure of wounds and tissue repair.GelMA hydrogels stand at the forefront of biomedical innovation, offering a versatile platform for addressing diverse challenges in drug delivery, tissue engineering, and wound healing. This review provides a comprehensive overview, fostering an in-depth understanding of GelMA hydrogel’s potential impact on progressing biomedical sciences.

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Application and progress of bionic scaffolds in nerve repair: a narrative review

Fang,

Nan,

Song

et al. 2024

Advanced Technology in Neuroscience

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Nerve injury can result in severe damage and potentially permanent disability, imposing substantial physical, psychological, and economic burdens on affected individuals and their families. Despite advances in surgical repair techniques, the functional recovery of nerves remains suboptimal. The current therapeutic approaches for nerve injury exhibit limited efficacy in restoring function, underscoring the imperative for the development of innovative treatment modalities. In recent years, bionics has emerged as a promising field in medicine, particularly in the treatment and rehabilitation of nerve injuries. We review the advances in the application of bionic technology within the realm of nerve injury treatment, encompassing bionic nerve scaffolds, nerve regeneration materials, and nerve modulation techniques. We delve into how these technologies may facilitate the repair and functional restoration of nerve tissues, as well as the challenges they encounter in clinical translation and their prospective directions for future development. Furthermore, we explore the convergence of bionic technology with existing therapeutic strategies and discuss the potential for interdisciplinary collaboration to catalyze innovation in nerve injury treatment. The integration of bionics with conventional methods may offer a synergistic approach, enhancing the efficacy of nerve repair and rehabilitation processes.

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Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration

Abstract: Chlorogenic acid (CGA) has been confirmed as a polyphenol, and existing research has suggested the high bioactivity of CGA for therapeutic effects on a wide variety of diseases. Despite the...

Cited by 3 publications

References 56 publications

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Application and progress of bionic scaffolds in nerve repair: a narrative review

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