Chlorophyll in wound healing and suppurative disease

Bowers, Warner F.

doi:10.1016/0002-9610(47)90287-0

Cited by 31 publications

(4 citation statements)

References 12 publications

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“…It has long been debated whether chlorophylls, and their natural or synthetic derivatives, could be absorbable by humans, despite the fact that their consumption has been documented for a long time in traditional medicine [42][43][44]. However, recent research has confirmed that chlorophyll derivatives are absorbable by the human intestine [45].…”

Section: Carotenes Chlorophylls and Other Unsaponifiable Compoundsmentioning

confidence: 99%

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

et al. 2020

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Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado–soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.

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Section: Carotenes Chlorophylls and Other Unsaponifiable Compoundsmentioning

confidence: 99%

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

et al. 2020

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“…Sodium copper chlorophyllin complex is a semisynthetic mixture of the water-soluble sodium salt of copper chlorophyllin and small molecule analogs derived from plant chlorophyll that possesses a unique combination of anti-inflammatory, antibacterial, and antioxidant activities. 6 Sodium copper chlorophyllin complex has been used topically for many years to aid in wound healing 7 – 9 but the ingredient has not been used until recently as an antiaging cosmeceutical in topical products. Sodium copper chlorophyllin complex has demonstrated inhibition of hyaluronidase activity in vitro, supporting the concept that topical application of sodium copper chlorophyllin complex may be useful in the regulation of HA in the skin, thereby acting to enhance the improvement in the appearance of facial skin.…”

Section: Introductionmentioning

confidence: 99%

Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix

McCook

Stephens

Jiang

et al. 2016

CCID

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PurposeTo examine the effect of sodium copper chlorophyllin complex on the expression of biomarkers of photoaged dermal extracellular matrix indicative of skin repair.Patients and methodsFollowing a previously published 12-day clinical assessment model, skin biopsy samples from the forearms of four healthy females with signs of photoaged skin were obtained and samples were analyzed by immunohistochemistry for key biomarkers of aging skin after each subject was treated with a test material consisting of a gel containing a liposomal dispersion of sodium copper chlorophyllin complex 0.05%, a positive control of tretinoin cream 0.025%, and an untreated negative control.ResultsThere was a statistically significantly greater amount of fibrillin/amyloid P and epidermal mucins found for skin treated with the test material containing 0.05% sodium copper chlorophyllin complex and the reference control tretinoin 0.025% cream compared to the negative control (untreated site). Expression of procollagen 1 and dermal mucin also showed a greater presence in the samples treated with the test material and the reference control compared to the negative control, though the differences were not statistically significant. No adverse events were observed or reported by the subjects during the course of the study.ConclusionThe results of this human biopsy study suggest that both retinoids and sodium copper chlorophyllin complex have beneficial effects on biomarkers of photoaged skin. Products containing both sodium copper chlorophyllin complex and retinols may provide a dual approach to reversing age-related decreases in hyaluronic acid (HA) in the skin: inhibition of the breakdown of HA via sodium copper chlorophyllin complex by inhibition of hyaluronidase, and stimulation of HA synthases by retinol.

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“…Sodium copper chlorophyllin complex has previously been used topically to aid in wound healing 10 – 13 but the ingredient has not been used therapeutically until recently as an anti-aging cosmeceutical in topical cosmetic and personal care products. 14…”

Section: Introductionmentioning

confidence: 99%

In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs

McCook

Dorogi

Vasily

et al. 2015

CCID

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BackgroundInhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents. Sodium copper chlorophyllin complex is being used therapeutically as a component in anti-aging cosmeceuticals, and has been shown to have anti-hyaluronidase activity. In this study we evaluated various commercial lots of sodium copper chlorophyllin complex to identify the primary small molecule constituents, and to test various sodium copper chlorophyllin complexes and their small molecule analog compounds for hyaluronidase inhibitory activity in vitro. Ascorbate analogs were tested in combination with copper chlorophyllin complexes for potential additive or synergistic activity.Materials and methodsFor hyaluronidase activity assays, dilutions of test materials were evaluated for hydrolytic activity of hyaluronidase by precipitation of non-digested hyaluronate by measuring related turbidity at 595 nm. High-performance liquid chromatography and mass spectroscopy was used to analyze and identify the primary small molecule constituents in various old and new commercial lots of sodium copper chlorophyllin complex.ResultsThe most active small molecule component of sodium copper chlorophyllin complex was disodium copper isochlorin e4, followed by oxidized disodium copper isochlorin e4. Sodium copper chlorophyllin complex and copper isochlorin e4 disodium salt had hyaluronidase inhibitory activity down to 10 µg/mL. The oxidized form of copper isochlorin e4 disodium salt had substantial hyaluronidase inhibitory activity at 100 µg/mL but not at 10 µg/mL. Ascorbate derivatives did not enhance the hyaluronidase inhibitory activity of sodium copper chlorophyllin. Copper isochlorin e4 analogs were always the dominant components of the small molecule content of the commercial lots tested; oxidized copper isochlorin e4 was found in increased concentrations in older compared to newer lots tested.ConclusionThese results support the concept of using the hyaluronidase inhibitory activity of sodium copper chlorophyllin complex to increase the hyaluronic acid level of the dermal extracellular matrix for the improvement of the appearance of aging facial skin.

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Chlorophyll in wound healing and suppurative disease

Cited by 31 publications

References 12 publications

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix

In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs

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