1993
DOI: 10.1136/bmj.307.6895.49
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Chloroquine poisoning. Rapidly fatal without treatment.

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Cited by 25 publications
(10 citation statements)
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“…Given concerns for rapid potassium shifts in toxicity and repletion, an alternative to succinylcholine should be considered for rapid sequence induction and paralysis to avoid provoking rapid onset of hyperkalemia. Additionally, clinicians should avoid barbiturates for induction, as they may precipitate sudden cardiac arrest [ 96 ].…”
Section: Discussionmentioning
confidence: 99%
“…Given concerns for rapid potassium shifts in toxicity and repletion, an alternative to succinylcholine should be considered for rapid sequence induction and paralysis to avoid provoking rapid onset of hyperkalemia. Additionally, clinicians should avoid barbiturates for induction, as they may precipitate sudden cardiac arrest [ 96 ].…”
Section: Discussionmentioning
confidence: 99%
“…Oral chloroquine is rapidly and almost completely absorbed from the GI tract, leading to rapid signs of toxicity with cardiac and neurologic systems predominating (4). As a result, ingestion of a surprisingly small amount of chloroquine has severe effects.…”
Section: Characteristicsmentioning
confidence: 99%
“…Chloroquine (CQ) was first synthesized in 1934 by the Bayer scientist Johann Anderstag and initially given the name resorchin (RESORcinate of 4‐aminoCHINolin) . Originally deemed too toxic for use in humans, it was rediscovered in the 1940s and has been widely used against malaria, with a high degree of success, since the 1950s . Several side effects result from excessive use of CQ, such as gastrointestinal distress, retinopathy, cardiac toxicity, and even death .…”
Section: Figurementioning
confidence: 99%
“…Several side effects result from excessive use of CQ, such as gastrointestinal distress, retinopathy, cardiac toxicity, and even death . These contraindications are likely due to CQ being a noted negative ionotrope, vasodilator, and inhibitor of intraventricular conduction . Malaria treatment requires high doses of CQ (up to 1 500 mg) over several days .…”
Section: Figurementioning
confidence: 99%