Chloroquine-Resistant Falciparum Malaria in Thailand

Harinasuta, T; Suntharasamai, Pravan; Viravan, C

doi:10.1016/s0140-6736(65)90395-8

Cited by 135 publications

(67 citation statements)

References 7 publications

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“…Whereas chloroquine resistance, which emerged in only a few independent locations, took 20 years to spread from its site of origin in southeast Asia to east Africa, 77,78 increased population movement between Asia and Africa is likely to shorten this time period. Worryingly, if artemisinin resistance has the capacity to emerge de novo at several locations, wherever the drug is used (as with low-grade resistance to pyrimethamine), then containment efforts will be almost impossible.…”

Section: Discussionmentioning

confidence: 99%

Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems

Talisuna

Karema

Ogutu

et al. 2012

The Lancet Infectious Diseases

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Artemisinin-resistant Plasmodium falciparum malaria has emerged in western Cambodia and has been detected in western Thailand. The situation is ominously reminiscent of the emergence of resistance to chloroquine and to sulfadoxine-pyrimethamine several decades ago. Artemisinin resistance is a major threat to global public health, with the most severe potential effects in subSaharan Africa, where the disease burden is highest and systems for monitoring and containment of resistance are inadequate. The mechanisms that underlie artemisinin resistance are not fully understood. The main phenotypic trait associated with resistance is a substantial delay in parasite clearance, so far reported in southeast Asia but not in Africa. One of the pillars of the WHO global plan for artemisinin resistance containment is to increase monitoring and surveillance. In this Personal View, we propose strategies that should be adopted by malaria-endemic countries in Africa: resource mobilisation to reactivate regional surveillance networks, establishment of baseline parasite clearance profiles to serve as benchmarks to track emerging artemisinin resistance, improved data sharing to allow pooled analyses to identify rare events, modelling of risk factors for drug resistance, and development and validation of new approaches to monitor resistance.

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Section: Discussionmentioning

confidence: 99%

Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems

Talisuna

Karema

Ogutu

et al. 2012

The Lancet Infectious Diseases

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“…CQ resistance was first reported at the Thai-Cambodian border [20], followed by drug resistance throughout the tropical world. In addition, sulfadoxine/pyrimethamine and mefloquine resistance [21] have also been reported.…”

Section: Treatment Of Benign Plasmodium Falciparum Infectionsmentioning

confidence: 99%

“…New compounds that are not effluxed from the brain were identified, for example SCYX-7158 advanced became a pre-clinical candidate at the end of 2009. M a n u s c r i p t 20 …”

Section: Sleeping Sicknessmentioning

confidence: 99%

Antiprotozoal compounds: state of the art and new developments

Astelbauer¹,

Walochnik²

2011

International Journal of Antimicrobial Agents

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“…Since the appearance of chloroquine-resistant P. falciparum strains in the 1960s, multidrug resistant P. falciparum has emerged and spread to most areas of the country (Harinasuta et al 1965;Hall et al 1975; Malikul 1 9 8 8 ; K a r b w a n g a n d H a r i n a s u t a 1 9 9 2 ; Charoenviriyaphap et al 2000). In contrast, drug resistance in P. vivax has not been reported in Thailand (Congpuong et al 2002;Tasanor et al 2006).…”

Section: Emergence Of Drug Resistance In Thailandmentioning

confidence: 99%