Chlorpheniramine—Sulfur Dioxide Interactions on Lung and Nasal Function in Allergic Adolescents

Abstract

Thirteen allergic adolescent subjects without clinical asthma but with exercise-induced bronchoconstriction participated in this study. In a double-blind protocol, they were given placebo, 4 mg, or 12 mg chlorpheniramine at bedtime the evening before exposure to 1 ppm sulfur dioxide (S02) during moderate exercise. Pulmonary function (forced expiratory volume in 1 second and total respiratory resistance) and nasal work of breathing were measured before and after exposure. Chlorpheniramine did not alter the statistically significant changes in pulmonary function seen after SO, exposure. However, 12 mg chlorpheniramine did block the S02-induced increase in the nasal work of breathing. It is concluded that treatment with an H, blocking antihistamine does not affect the mecha¬ nisms underlying S02-induced bronchoconstriction, although it does inhibit S02-induced nasal function changes.

Usage of traditional Chinese medicine, Western medicine and integrated Chinese-Western medicine for the treatment of allergic rhinitis

“…(Figure 1) bronchodilators can also be found in western medicines that have been used to treat allergic rhinitis. [8,28,29] Ephedra and pseudoephedrine can combine and cause sudden hypertension and severe depression: increased cardiac speed and anxiety. [30][31] Materials and Methods NHI reimburses Chinese medicine only for the manufacture of Chinese medicinal products except for raw material and other herbal medicinal products.…”

Usage of Traditional Chinese Medicine, Western Medicine and Integrated ChineseWestern Medicine for the Treatment of Allergic Rhinitis

“…The components in ephedra are also known to activate the central nervous system, triggered by ephedrine and D-pseudoephedrine, insomnia and mental agitation. Only pseudoephedrine, antihistamines and bronchodilators can also be found in western medicines that have been used to treat allergic rhinitis [8,28,29] . Ephedra and pseudoephedrine can combine and cause sudden hypertension and severe depression: increased cardiac speed and anxiety [30,31] .…”