Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells

Saulsbury, Marilyn D.; Heyliger, Simone O.; Wang, Kaiyu; Johnson, Deadre J.

doi:10.1016/j.tox.2008.12.026

Cited by 120 publications

(60 citation statements)

References 71 publications

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“…Experimental studies have demonstrated that CPF exposure results in inhibition of DNA synthesis, induces apoptosis and leads to adverse neurodevelopmental problems in the central nervous system, and the mechanism proposed for toxicity of CPF is oxidative stress which may be via production of reactive oxygen species (ROS) from mitochondria (Cho, Nakamura, & Lipton, 2010;Lee, Park, Shin, & Koh, 2012;Moser, 2000;Saulsbury, Heyliger, Wang, & Johnson, 2009). ROS produced during oxidative stress have been reported to initiate signalling cascades leading to apoptosis (Yu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Zhang

Chang

Hong-ping

et al. 2017

Food and Agricultural Immunology

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Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the potential threat and the molecular mechanism of CPF toxicity to human liver have not been wellcharacterized. In this study, we identify cytotoxicity of CPF to human normal liver cells in vitro. We demonstrate that the viability of QSG7701 cells is inhibited by CPF in a time-and concentration-dependent manner. Intracellular biochemical assays showed that CPF-induced apoptosis of QSG7701 cells concurrent with a decrease in the mitochondrial membrane potential, the release of cytochrome c into the cytosol, up-regulate the expression level of Bax/Bcl-2 and a marked activation of caspase-9/-3. These results indicate that CPF has a potential risk to human liver that can induce apoptosis of human liver cells through caspase-dependent mitochondrial pathways. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Zhang

Chang

Hong-ping

et al. 2017

Food and Agricultural Immunology

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“…1 However, it is well known that OPs, for which suspicion of teratogenic, carcinogenic, and/or mutagenic effects in man exists, are still in use. 2 Malathion has harmful effects on various organs systems, including the kidney, 3 liver, 3 lung, 4 brain, 5 and erythrocytes. 6 This insecticide is metabolized in the liver by multiple specific cytochrome P450 enzymes through several reaction pathways.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Selmi

Jallouli²,

Gharbi³

et al. 2015

Journal of Medicinal Food

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We aimed in the present study to investigate the hepato-and nephroprotective effects of Lavandula stoechas essential oils (LSEO) against malathion-induced oxidative stress in young male mice as well as the possible mechanism implicated in such protection. Animals were divided into eight groups of 12 each: Control, malathion (200 mg/kg b.w.); Various doses of LSEO (10, 30, and 50 mg/kg b.w.), malathion + various doses of LSEO. Malathion and LSEO were daily per orally (p.o.) administered by intragastric gavage during 30 days. We initially found that malathion treatment induced body weight gain decrease as well as a clear nephro-and hepatotoxicity as assessed by significant relative liver and kidney weight increase and related hemodynamic parameters deregulation. Malathion exposure of mice also induced a considerable perturbation of metabolic parameters. On the other hand, we showed that malathion administration was accompanied by an oxidative stress status assessed by an increase of malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels as well as a depletion of sulfhydril group content (-SH) and antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD, and Fe-SOD in the kidney and liver. More importantly, LSEO treatment abolished all malathion-induced body gain loss, liver and kidney relative weight increase, hemodynamic and metabolic disorders, as well as hepatic and renal oxidative stress. In conclusion, our data suggest that LSEO exerted potential hepato-and nephroprotective effects against malathion-induced oxidative stress in mice. The beneficial effect of LSEO might be related, in part, to its antioxidant properties.

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“…Similarly, CPF is a developmental neurotoxicant (Qiao et al, 2003;Dietrich et al, 2005;Colborn, 2006;Slotkin et al, 2006;) impairing children mental and behavioral health (Lizardi et al, 2008). Although, CPF like the other OP compounds phosphorylates and subsequently inactivate AChE, neurobehavioural and cognitive deficits have however been observed following repeated low-dose CPF exposure that cannot be attributed to the usual AChE inhibition and muscarinic receptor binding (Pope et al, 1992;Chakraborti et al, 1993;Saulsbury et al, 2009). Earlier studies have shown the involvement of oxidative stress in the neurotoxicity induced by CPF exposure (Gultekin et al, 2007;Ambali et al, 2010a;Ambali & Aliyu, 2012;Ambali andAyo, 2011a, 2011b).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Vitamin E on Sensorimotor and Cognitive Changes Induced by Chronic Chlorpyrifos Exposure in Wistar Rats

Ambali¹,

Ayo²,

Shittu³

et al. 2012

Insecticides - Basic and Other Applications

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Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells

Cited by 120 publications

References 71 publications

Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Ameliorative Effect of Vitamin E on Sensorimotor and Cognitive Changes Induced by Chronic Chlorpyrifos Exposure in Wistar Rats

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