Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Abstract

We aimed in the present study to investigate the hepato-and nephroprotective effects of Lavandula stoechas essential oils (LSEO) against malathion-induced oxidative stress in young male mice as well as the possible mechanism implicated in such protection. Animals were divided into eight groups of 12 each: Control, malathion (200 mg/kg b.w.); Various doses of LSEO (10, 30, and 50 mg/kg b.w.), malathion + various doses of LSEO. Malathion and LSEO were daily per orally (p.o.) administered by intragastric gavage during 30 days. We initially found that malathion treatment induced body weight gain decrease as well as a clear nephro-and hepatotoxicity as assessed by significant relative liver and kidney weight increase and related hemodynamic parameters deregulation. Malathion exposure of mice also induced a considerable perturbation of metabolic parameters. On the other hand, we showed that malathion administration was accompanied by an oxidative stress status assessed by an increase of malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels as well as a depletion of sulfhydril group content (-SH) and antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD, and Fe-SOD in the kidney and liver. More importantly, LSEO treatment abolished all malathion-induced body gain loss, liver and kidney relative weight increase, hemodynamic and metabolic disorders, as well as hepatic and renal oxidative stress. In conclusion, our data suggest that LSEO exerted potential hepato-and nephroprotective effects against malathion-induced oxidative stress in mice. The beneficial effect of LSEO might be related, in part, to its antioxidant properties.

A Phytopharmacological review of a Mediterranean plant: Lavandula stoechas L

“…The antioxidant characteristics of the phenolic compounds in L. stoechas are mainly attributed to their ability to eliminate free radicals; for example, they reduce oxidative stress induced in diabetic rats [74] and have hepatoprotective and renoprotective effects against malathioninduced oxidative stress in young male mice [76].…”

Ameliorative Effects of Hydroalcoholic Extract of Lavandula officinalis L. on Methotrexate-Induced Oxidative Stress in Rats

“…An increase in intracellular GPx level induced by LOE has been indicated in earlier reported. 29 At the same time, oral administration of LOE significantly decreases the hepatic MDA of the rats of groups 4 and 5 when compared with the MTX group (p<0.05). These results of LOE might be the schedule for the defense against pathological alterations in liver in rats induced by MTX.…”

“…These results were similar to several studies who reported that LOE reversal of enhanced serum enzymes on induced liver damage by Malathion and Alloxan. 28,29 Reactive oxygen species (ROS; •OH, O2-, RO, ROO, NO) play main role in enhance of MTXinduced cellular damages in liver tissue. Induced of oxidative stress due of ROS may lead to initiation and progression of some disease such as cardiovascular, diabetes and neurodegenerative disorders.…”

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

“…Previous studies have shown that essential oil has hepatoprotective effects in various animal models (Bouzenna et al, 2016[ 14 ]; Jiang et al, 2019[ 43 ]; Morales-López et al, 2017[ 58 ]; Özbek et al, 2016[ 62 ]; Selmi et al, 2015[ 73 ]). P. minus contains various medicinal values and yields high levels of essential oil (72.54 %) mainly of aliphatic aldehydes, terpenoids and organic acids (Baharum et al, 2010[ 10 ]).…”