Cholecystokinin and panic disorder

Bourin, Michel; Dailly, Éric

doi:10.1111/j.1601-5215.2004.0076.x

Cited by 11 publications

(3 citation statements)

References 77 publications

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“…In the elevated T-maze, the same peptide markedly increased escape behavior while causing only a marginal facilitatory effect on inhibitory avoidance (Zanoveli et al, 2004). This effect on escape is in accordance with a wealth of evidence showing that agonists of CCK receptors induce panic attacks in healthy volunteers and in panic disorder patients (Bourin and Dailly, 2004).…”

Section: Discussionsupporting

confidence: 65%

Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze

Bertoglio¹,

Zangrossi²

2006

Behavioural Pharmacology

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The involvement of the dorsolateral periaqueductal gray in the regulation of fear-related behaviors such as escape and freezing is well established. It is still a matter of investigation, however, whether this midbrain area may have a relevant role in the modulation of more subtle defensive responses associated with anxiety such as risk assessment and inhibitory avoidance. By stimulating N-methyl-D-aspartic acid glutamate receptors located in the dorsolateral periaqueductal gray with its prototypical agonist N-methyl-D-aspartic acid (50 pmol), we report here an increase in both risk assessment and inhibitory avoidance behaviors of male Wistar rats tested in the elevated T-maze. These results are indicative of an anxiogenic-like effect. The selective N-methyl-D-aspartic acid receptor antagonist DL-2-amino-7-phosphonoheptanoic acid (2.0 and 4.0 nmol) had the opposite effect on both defensive tasks. Pretreatment with an ineffective dose of DL-2-amino-7-phosphonoheptanoic acid (1.0 nmol) prevented the N-methyl-D-aspartic acid anxiogenic-like effect. At the dose range of DL-2-amino-7-phosphonoheptanoic acid and/or N-methyl-D-aspartic acid tested, neither the escape response from one of the elevated T-maze open arms nor the general exploratory activity as assessed in the open-field test was affected. The present results suggest that the dorsolateral periaqueductal gray column is also involved in the regulation of defensive behaviors related to anxiety, and N-methyl-D-aspartic acid glutamate receptors are recruited for this action.

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Section: Discussionsupporting

confidence: 65%

Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze

Bertoglio¹,

Zangrossi²

2006

Behavioural Pharmacology

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“…In contrast to the apparent general effects of COMT, the role of the CCK-B receptor gene seems to be implicated in a more specific way to PD (Hösing et al, 2004;Kennedy et al, 1999). There is ample evidence that cholecystokinin and the CCK-B receptor play a considerable role in the neurobiology in PD as described in animal studies, challenging studies, and genetic studies (Bourin and Dailly, 2004;Bradwejn and Koszycki, 2001). As the COMT variant as well as the CCK-B receptor CT repeat in the promoter region are associated with PD in Caucasians, the question arises as to whether PD is the result of a combination of general deficits, for example, COMT, or combined with specific ones, for example, cholecystokinin.…”

Section: Discussionmentioning

confidence: 99%

Association of the Val158Met Catechol O-Methyltransferase Genetic Polymorphism with Panic Disorder

Rothe

Koszycki

Bradwejn

et al. 2006

Neuropsychopharmacol

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Genetic as well as clinical data suggest that catechol O-methyltransferase (COMT) is involved in multiple complex psychiatric conditions. Recent studies have described an association between the Val158Met COMT polymorphism and panic disorder. Other recent investigations provide evidence that there are other loci within or nearby the COMT gene that may contribute to the susceptibility to panic disorder. To further evaluate the influence of the Val158Met COMT polymorphism in panic disorder we genotyped this marker in the coding region of the COMT gene and two additional variants (rs737865 and rs165599) in the 5 0 and the 3 0 region, respectively, in two independent Canadian samples: 121 nuclear families, and 89 cases with matched controls. In the nuclear families, significant transmission disequilibrium for the valine allele was observed between the alleles of the Val158Met COMT polymorphism and panic disorder (po0.01). A significant excess of the valine allele was found in analysis of the case-control sample (po0.01). This effect was mainly derived from the subgroup of females. This finding, including the female effect, replicates earlier results in studies of the Val158Met polymorphism in panic disorder. No significant results were found for the other two markers. These results support the hypothesis that the valine allele of the Val158Met COMT polymorphism or a nearby locus is involved in the etiopathogenesis of panic disorder.

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“…CCK is one of the most abundant neurotransmitter peptides in the brain and has been shown to induce excitation of central neurons as well as inhibitory post-synaptic effects (Bourin & Dailly 2004). CCK-1 and -2 receptors (G protein-coupled receptors) (recently reclassified as A and B) are widely distributed throughout the CNS.…”

Section: Neurochemistrymentioning

confidence: 99%

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Bandelow

Baldwin

Abelli

et al. 2016

The World Journal of Biological Psychiatry

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268

165

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Cholecystokinin and panic disorder

Cited by 11 publications

References 77 publications

Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze

Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze

Association of the Val158Met Catechol O-Methyltransferase Genetic Polymorphism with Panic Disorder

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

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