Choledocho-Enterostomy and Postoperative Dilation of the Bile-Ducts

Barber, W. Howard

doi:10.1097/00000658-191911000-00004

Cited by 3 publications

(5 citation statements)

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“…If the study did not report neo-bile duct regeneration and the histology was similar to that of the native bile duct, the tissue was excluded from evaluation. The histology of the anastomotic site between the BDS and native bile duct was examined because the bile duct epithelium is continuous at the anastomotic site if stenosis of the anastomotic site does not occur[ 38 ].…”

Section: Methodsmentioning

confidence: 99%

“…As such, this material may be unsuitable because the BDS lumen may be blocked by a bile plug[ 21 , 22 ]. In addition, the epithelium does not regenerate continuously at the anastomotic site between the BDS and native bile duct, scar contraction occurs in the long term after transplantation[ 38 ]. A bile plug may form if a tubular stent is inserted to secure bile passage, even when using non-bioabsorbable materials.…”

Section: Bds Reported To Datementioning

confidence: 99%

“…Bile may flow out of the BDS transplantation site, making this material unsuitable for BDS. With regard to cell adhesion, the scaffold itself (for example, PGA only) has lower cell adhesion compared to collagen-based scaffolds owing to the lack of receptors for cell adhesion[ 38 ]. Therefore, to regenerate the scaffold itself within the bile duct, materials in which receptors are added to the scaffold have been investigated[ 38 ].…”

Section: Bds Reported To Datementioning

confidence: 99%

“…With regard to cell adhesion, the scaffold itself (for example, PGA only) has lower cell adhesion compared to collagen-based scaffolds owing to the lack of receptors for cell adhesion[ 38 ]. Therefore, to regenerate the scaffold itself within the bile duct, materials in which receptors are added to the scaffold have been investigated[ 38 ]. Failure of the bile duct to regenerate in the scaffold part while being absorbed prevents clinical application as a BDS; hence, these materials remain in the development stage.…”

Section: Bds Reported To Datementioning

confidence: 99%

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Pitfalls and promises of bile duct alternatives: A narrative review

Miyazawa¹,

Aikawa²,

Takashima³

et al. 2022

World J Gastroenterol

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Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde cholangitis. This chronic inflammation can cause liver dysfunction, liver abscess, and even bile duct cancer. Although research has been conducted for over 100 years to directly repair bile duct defects with alternatives, no bile duct substitute (BDS) has been developed. This narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near future. We searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in English. Two independent reviewers reviewed studies on large animals with 8 or more cases. Four types of BDSs prevail: Autologous tissue, non-bioabsorbable material, bioabsorbable material, and others (decellularized tissue, 3D-printed structures, etc. ). In most studies, BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile duct. BDS has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated. A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS.

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Section: Methodsmentioning

confidence: 99%

Section: Bds Reported To Datementioning

confidence: 99%

Section: Bds Reported To Datementioning

confidence: 99%

Section: Bds Reported To Datementioning

confidence: 99%

See 2 more Smart Citations

Pitfalls and promises of bile duct alternatives: A narrative review

Miyazawa¹,

Aikawa²,

Takashima³

et al. 2022

World J Gastroenterol

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“…At the anastomotic site, no epithelium was observed at 3 W after transplantation, but at 7 W, the native bile duct and native duodenum were found to be continuous. Thus, this could be used as an evaluation method for bile duct stenosis 47 .…”

Section: Bile Duct Regeneration Using This Abd As a Bile Duct Substitutementioning

confidence: 99%

Cell-free scaffold for regenerating defective bile ducts

Miyazawa,

Aikawa,

Takashima

et al. 2023

Preprint

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Much research has focussed on restoring the defective part of the gastrointestinal tract, which is considered the best way to preserve function. However, to date, no method for reconstructing the gastrointestinal tract has been developed. Here, we report a bile duct replacement method that does not require cell culture and that replaces defective bile ducts thus enabling bile duct regeneration without stenosis. The bioabsorbable bile duct substitute (BDS) (artificial bile duct (ABD); absorption period of 6–8 weeks) that we have developed is capable of reliably regenerating bile ducts, including Y-shaped bile ducts, without attaching cells to the ABD, and it can regenerate the bile duct without stenosis. Bile duct regeneration occurred in the lateral part of the ABD after the ABD passed into the duodenum. Immature cells that regenerated the bile ducts adhered to the outside of the ABD, and the adhered cell clusters formed peribiliary glands, which regenerated as mature bile duct epithelium. Furthermore, cells that adhered to the outside of the ABD regenerated bile duct epithelial cells, peribiliary glands, and fibromuscular layers into structures similar to those of the native bile duct. These results indicate that the use of this bioabsorbable BDS to restore the bile duct is a minimally invasive treatment that preserves function in the hepato-biliary-pancreatic area.

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The diagnosis and treatment of penetrating abdominal wounds

Eisberg

1928

The American Journal of Surgery

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Choledocho-Enterostomy and Postoperative Dilation of the Bile-Ducts

Cited by 3 publications

References 0 publications

Pitfalls and promises of bile duct alternatives: A narrative review

Pitfalls and promises of bile duct alternatives: A narrative review

Cell-free scaffold for regenerating defective bile ducts

The diagnosis and treatment of penetrating abdominal wounds

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