Choleretic action of andrographolide obtained from <i>Andrographis paniculata</i> in rats

Tripathi, G.; Tripathi, Yamini B.

doi:10.1002/ptr.2650050408

Cited by 12 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Andrographolide, a diterpene lactone (see structure) isolated from Andrographis paniculata (Acanthaceae), has been shown to possess hepatoprotective activity against hepatotoxins including carbon tetrachloride (Handa and Sharma, 1990a;Kapil et al, 1993), galactosamine and paracetamol (Handa and Sharma, 1990b;Visen et al, 1993) and ethanol (Pramyothin et al, 1994). Andrographolide has also been shown to have antidiarrhoeal (Gupta et al, 1990), choleretic (Tripathi and Tripathi, 1991;Shukla et al, 1992) and analgesic, antipyretic and antiulcerogenic effects (Madav et al, 1995). Madav et al (1996) have recently reported the in vivo antiinflammatory activity of andrographolide.…”

Section: Introductionmentioning

confidence: 99%

Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion

Habtemariam

1998

Phytother. Res.

View full text Add to dashboard Cite

Andrographolide, a diterpene isolated from Andrographis paniculata, has been shown to have several biological activities including analgesic, antipyretic and antiinflammatory effects. Since the upregulation of adhesion molecules expression and endothelial‐leucocytes adhesion are key steps in the development of inflammation, the present study examines whether andrographolide modulates these biological processes in vitro. Incubation of endothelial cells with non‐toxic concentrations (0.16–16.7 υg/mL) of andrographolide attenuated the tumour necrosis factor‐α (TNF)‐induced intercellular adhesion molecule‐1 (ICAM‐1) expression. Similar concentration ranges of andrographolide also inhibited the TNF‐induced endothelial‐monocyte adhesion in a concentration‐dependent manner. These effects of andrographolide may account for its reported in vivoantiinflammatory activity. © 1998 John Wiley & Sons, Ltd.

show abstract

Section: Introductionmentioning

confidence: 99%

Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion

Habtemariam

1998

Phytother. Res.

View full text Add to dashboard Cite

show abstract

Present status of hepatoprotectants

Ram

Goel

1999

Progress in Drug Research

View full text Add to dashboard Cite

Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran’s pharmaceutical plants

et al. 2011

View full text Add to dashboard Cite

Nain-e Havandi (Andrographis paniculata Nees.) (AP) is an annual herbaceous plant belonging to the family Acanthacea. Only a few species of Andrographis genus out of 28 are medicinally concerned of which AP is the most important. Knowledge about the arrival of AP to Iran is extremely lacking but most probably it has been imported from India. However, evidence implies the familiarity of Iran's folkloric medicine with this plant, but it has been disappeared from contemporary medicine for unknown reasons. Presence of active ingredients from diterpenoids group such as andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide has given incredible unique medicinal properties to the plant. Traditionally, Nain-e Havandi has been used in the role of a non-farm plant as a remedy for skin problems, flu, respiratory disease, and snakebite in East and Southeast Asia for centuries. Recently, it has been utilized as a treatment for HIV, hepatitis, diabetes, cancer and kidney disorders. Intensive cultivation of the herb started only in the past decade in countries such as China, India, Thailand, Indonesia, West Indies, Mauritius and to some extent, in Malaysia. Availability of different ecological zones in Iran complies with reestablishment of AP in tropical and temperate regions of the country. This is killing two birds with one stone, supporting the conservational and economic aspects.

show abstract

Choleretic action of andrographolide obtained from Andrographis paniculata in rats

Abstract: Andrographolide, a diterpene, isolated from Androgruphis puniculala exhibited a strong choleratic action when administered intraperitoneally (i.p.) to albino rats. This substance induced an increase in bile flow together with a change in the physical properties of the bile secretion.

Cited by 12 publications

References 5 publications

Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion

Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion

Present status of hepatoprotectants

Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran’s pharmaceutical plants

Contact Info

Product

Resources

About