Cholestatic jaudice due to toxoplasma hepatitis

Abstract

Summary A case of toxoplasma hepatitis presenting with cholestatic jaundice is described. The diagnosis was based on serological testing and evidence of hepatitis on biopsy.

Acute acquired toxoplasmosis: clinical-laboratorial aspects and ophthalmologic evaluation in a cohort of immunocompetent patients

“…The presence of liver enlargement and altered biochemical liver function tests indicates hepatic involvement, even in the absence of jaundice. Abnormalities in liver function have been noted by other authors (Tiwari et al 1982, McCabe et al 1987. It is worth noting the absence of abdominal lymph node enlargement.…”

Peroral Infectivity of Toxoplasma gondii in Bile and Feces of Interferon‐γ Knockout Mice

“…Previous studies (20,23) reported cholestatic jaundice due to T. gondii infection, although the pathogenicity of the jaundice was not revealed. The present results suggested the existence of a novel migration route of T. gondii, from liver to bile and bile to feces, in immunocompromised GKO mice.…”

Liver and Bile Duct Infections

“…Hepatitis has been reported in apparently healthy persons during acute infection; these patients present with jaundice, rash, and elevated levels of transaminases and alkaline phosphatase. [492][493][494][495] Histologically, Toxoplasma hepatitis is characterized as a diffuse hepatitis with infiltration of portal tracts and sinusoids by mononuclear cells associated with focal hepatic necrosis, similar to EBV or CMV hepatitis. [492][493][494] Granulomatous hepatitis has also been described.…”

“…[492][493][494][495] Histologically, Toxoplasma hepatitis is characterized as a diffuse hepatitis with infiltration of portal tracts and sinusoids by mononuclear cells associated with focal hepatic necrosis, similar to EBV or CMV hepatitis. [492][493][494] Granulomatous hepatitis has also been described. 495 In some cases, bradyzoite-containing Toxoplasma cysts have been identified in histiocytes and granulomas or within the hepatic parenchyma.…”

“…495 In some cases, bradyzoite-containing Toxoplasma cysts have been identified in histiocytes and granulomas or within the hepatic parenchyma. [493][494][495][496] Free tachyzoites have been described within degenerating or necrotic hepatocytes, although they can be difficult to distinguish from detritus. 492,495 Giemsa stain, PAS, immunohistochemical stains, or immunofluorescent stains may assist in the detection of organisms in tissue.…”