Cholesterol esterase activity of normal and atherosclerotic rabbit aorta

Lysosomal Acid Cholesteryl Esterase and Atherosclerosis in Cholesterol-Fed Rabbits

“…1) (29). Cholesteryl esterase activity with a pH optimum in the neighborhood of neutrality, on the other hand, has been demonstrated by other researchers in the aorta of several animal species (2,6,12,(15)(16)(17)20). It seems liekly that differences in assay conditions account for the differences between our results and those of others.…”

Uptake and Metabolism of 14 C-Labeled Oleic Acid by Atherosclerotic Lesions in Rabbit Aorta

“…Such studies have indicated that the phospholipid accumulates in the lesion as a result of synthesis in situ (7,8). Recent evidence indicates that synthesis and hydrolysis of cholesterol ester may also take place in the arterial lesion (9)(10)(11). The diversion of fatty acid synthesized from 1 4 C-labeled acetate to cholesterol ester in atherosclerotic lesions in the pigeon (12) and the rabbit (13) has also emphasized the potential role of the arterial wall in the esterification of cholesterol in the atherosclerotic lesion.…”

Investigations of the Aortic Phospholipase A, Lipase and Cholesterol Esterase

“…Hydrolysis of cholesteryl oleate in the presence of arterial tissue from normal and atherosclerotic rabbits was reported by Day and Gould-Hurst [7]. Recent investigations by Eisenberg, Stein and Stein confirmed the phospholipase A and lysolecithinase activities of the arterial wall [9].…”