Cholesterol‐/Estradiol‐Appended Alkynylplatinum(II) Complexes as Supramolecular Gelators: Synthesis, Characterization, Photophysical and Gelation Studies

Li, Yongguang; Lam, Elizabeth Suk-Hang; Tam, Anthony Yiu‐Yan; Wong, Keith Man‐Chung; Lam, Wai Han; Wu, Lixin; Yam, Vivian Wing‐Wah

doi:10.1002/chem.201301510

Cited by 27 publications

(14 citation statements)

References 81 publications

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“…To date, it has been reported that, in either organic or aqueous media, luminescent Pt(II) complexes are able to form homo- 82,83 and hetero-metallic [84][85][86] supramolecular architectures and superstructures such as nanowires, 87 nanosheets, nanowheels, nanotubes, 88 liquid crystals, 89 and metallogels 90,91 with very appealing (electro)optical, [92][93][94] sensing 95,96 and semiconducting properties. 97 Also, it has been nicely shown that the formation of such metallophilic interactions in luminescent square planar platinum complexes, and the subsequent modulation of their photophysical properties, can be induced by the presence of biologically relevant molecules and polyelectrolytes in aqueous media.…”

Section: Basic Photophysics Of D 8 Transition Metal Complexesmentioning

confidence: 99%

When self-assembly meets biology: luminescent platinum complexes for imaging applications

et al. 2014

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Luminescent platinum complexes have attractive chemical and photophysical properties such as high stability, emission in the visible region, high emission quantum yields and long excited state lifetimes. However the absorption spectrum of the compounds in the UV region, preventing their excitation in the harmless visible/red region, as well as the strong quenching of the luminescent triplet state, caused by dioxygen in water and biological fluids, reduces their possible applications for imaging. Therefore a possible solution to these drawbacks is to take advantage of the high tendency of such square planar compounds to self-assemble in supramolecular structures. The assemblies can be considered new chemical species with enhanced and tunable properties. Furthermore the assembly and disassembly process can be explored as a tool to obtain dynamic labels that can be applied in biomedicine. The change in color, the turn on and off of luminescence but also of the reactivity, the protection from quenching and environmental degradation are some of the attractive properties connected to the aggregation of the complexes.

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Section: Basic Photophysics Of D 8 Transition Metal Complexesmentioning

confidence: 99%

When self-assembly meets biology: luminescent platinum complexes for imaging applications

et al. 2014

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“…With a similar structure, the complex 5a-5d showed thixotropic properties. 38 For example, shaking the gel of 5d (10 mg mL À1 in cyclohexane obtained by a heatingcooling process) with a vibrator for 5 min would disturb the gel completely, a state that would persist for half an hour, and the gel would then reform.…”

Section: Metallogelsmentioning

confidence: 99%

Low-molecular-mass gels responding to ultrasound and mechanical stress: towards self-healing materials

et al. 2014

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In this review, we focus on the types of smart supramolecular gels whose self-assembly processes are affected or even triggered by physical forces including sonication and mechanical stress (mechanical force). The types of gels that are responsive to sonication and mechanical stress are examined and summarised. The gels exhibit non-covalent interactions among the gelator molecules and show dynamic and reversible properties controlled by the stimuli. Upon stimulation, the gelators cause instant and in situ gelation of organic solvents or water with different modes and outcomes of self-assembly. On the other hand, sonication and mechanical stress, as external factors, can give rise to dynamic changes in microscopic morphology, optical properties, etc. Certain thixotropic supramolecular gels exhibit perfect self-healing characteristics. The driving forces and the mechanism of the self-assembly process and the responsive outcome of morphological and spectroscopic changes are discussed. Those supramolecular gels responding to sonication and mechanical stress offer a wide range of applications in fields such as smart and adaptive materials, switches, drug control and release, and tissue engineering.

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“…52,54 In this study, we report nucleoside based hydrogels showing metal ion dependent self-healing properties which is unprecedented. The use of metal ions in making supramolecular gels 50,55,[59][60][61][62][63][64][65][66][67][68][69][70] is a potent approach with unusual properties and most of the reported metallogels lack a deeper insight into the ne-tuning of gel properties by using different metal ions. Interestingly, in our study, most of the dG gels show an excellent thixotropic property whereas G gels lack such a property.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly of guanosine and deoxy-guanosine into hydrogels: monovalent cation guided modulation of gelation, morphology and self-healing properties

2014

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+ on the stimulation of purine nucleosides guanosine (G) and deoxy-guanosine (dG) to self-assemble into hydrogels. The gelation properties in terms of gel crystallization, lifetime stability, thermo-reversibility, minimum gelation concentration, gel melting temperature, thixotropic property and others were thoroughly investigated and compared not only between two nucleosides but also among different metal ions. A few metal ions were found to induce G/dG to form gels with much improved lifetime stability. The results revealed that dG is a much better gelator than G for introduction of a thixotropic property. Interestingly, morphological, fluorescence and rheological (thixotropic) properties of the gels were found to modulate significantly by changing the metal ions. In the presence of K + ions, G produces a self supporting tight gel but it has poor lifetime stability. In contrast, the presence of K + ions stimulates dG to form a very loose gel but with excellent lifetime stability and thixotropic property. In this context, we have successfully engineered a self-supporting stable co-gel using a simple co-gelation method by mixing an equimolar amount of K + induced G and dG gels and this co-gel shows long lifetime stability, self-healing and injectable properties which may allow for a broad range of biological applications.Furthermore, an Ag + induced G gel was exploited for the light triggered in situ fabrication of uniform AgNPs within a gel to make a nano-bio hybrid material.

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Cholesterol‐/Estradiol‐Appended Alkynylplatinum(II) Complexes as Supramolecular Gelators: Synthesis, Characterization, Photophysical and Gelation Studies

Cited by 27 publications

References 81 publications

When self-assembly meets biology: luminescent platinum complexes for imaging applications

When self-assembly meets biology: luminescent platinum complexes for imaging applications

Low-molecular-mass gels responding to ultrasound and mechanical stress: towards self-healing materials

Self-assembly of guanosine and deoxy-guanosine into hydrogels: monovalent cation guided modulation of gelation, morphology and self-healing properties

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