Cholesterol Mediated Stable Vesicles: A Nano Drug Delivery Vehicle for Anti‐cancer Drugs Curcumin and 5‐Fluorourecil

Abstract

Hierarchical self-assembly of new age surfactants, surface-active ionic liquids (SAILs) has attracted increasing interests because of its close resemblance to membrane mimetic structure and its application in drug delivery. Among these self-assembled structures, thermodynamically stable vesicular nanoaggregates are of great importance due to its structure that can carry both, hydrophilic and hydrophobic molecules within its core and bilayers, respectively. Here, we report the ester functionalized SAILs to synergistically interact with cholesterol, the natural sterol to transform the micellar nano-aggregates to the vesicular nano-aggregates with outstanding stability with dilution, pH, and temperature. The molecular self-assembly formed was studied through state of the art analytical techniques including small-angle neutron scattering (SANS) and fluorescence resonance energy transfer (FRET) upon varying the cholesterol/SAIL ratio. The thermodynamically stable vesicular nano-aggregates were further used as the nano-vehicles for the encapsulation and sustained release of the anticancer drugs, curcumin and 5-flurouracil. Results of the present study could pave way for the realistic drug delivery applications of these thermodynamically stable nano-aggregates and replace the traditional lipid based vesicle systems.

Metal organic framework coated vesicular nano-aggregates: an intelligent ‘vehicle’ for sustained and leakage proof release of doxorubicin

“…This implies that the vesicular aggregates formed by the ester functionalized morpholinium-based system exhibit robust stability even under conditions of substantial dilution. 21,47 We also show that vesicles and nanocomposites have pH stability using DLS-size (hydrodynamic radius) experiments. 63,64 The size of the NaDC/C 12 EMorphBr vesicles is stable in the pH range of 4-8; however, above pH 8, the vesicles may breakdown and precipitate out of solution, increasing the size of the solution (Fig.…”

Unveiling the Potential of Surface Active Ionic Liquids Based Catanionic Vesicles for Tailored Delivery of Curcumin and its Enhanced Therapeutic Efficacy

“…As demonstrated in Table 3 [4] for [Ch][Ol]/GA vesicles it is 44.92 Å, [25a] for Cho/[C 12 EMorph][Br] vesicles it is 36.5 Å. [23]…”

Electrochemical and Spectroscopic Studies Performed for Indomethacin and 1-Naphthol Incorporated in 1-Butyl-3-methyl-imidazolium Bis(2-ethylhexyl) Sulfosuccinate Vesicles to Investigate Them as a Potentially pH-Sensitive Nanocarrier

“…When electrochemical and fluorescence studies were carried out using Np and IND at different pH levels, it was observed that neutral species undergo a partitioning process between the Bmim-AOT LUVs and water pseudophases, while the anionic species do not partition due to the characteristics of the bilayer. In this way, physicochemical properties such as size, surface charge, partition constants, and other characteristics of the bilayer were investigated to use these vesicles as possible candidates for drug-delivery agents in the future. − …”