Cholesterol Metabolism in Man

Effects of Exercise on Plasma and Liver Lipids of Rats

“…In general, the concentration of plasma choles terol is related to the rate of entry into and removal from that compartment. In the animals fed no cholesterol, entry into plasma are almost, but not entirely, dependant on the rate of cholesterol synthesis in the liver (28). As shown in tables III and V, hepatic HMG-CoA reductase activity and incorporation of mevalonate into cholesterol in the exercised rats were significantly higher com pared with those of the sedentary groups, indicating that exercise influences the entire process of cholesterogenesis and Aleksandrow et al (1) reported that, when rats were administered exercise for 35 and 168 days, respectively and received radioactive acetate intraperitoneally, incorporation of the label into hepatic cholesterol was significantly higher in the exercised group than in the sedentary group.…”

“…Sodhi (28) has predicted that, when plasma cholesterol decreased under the condition in which hepatic cholesterol synthesis is enhanced, the turnover rate of plasma cholesterol should increase. Unpublished experiments from our labora tory have shown that in rats administered treadmill running for 14 days and received 4-14C-cholesterol intraperitoneally or orally, the turnover of serum cholesterol and the excretion of the label as neutral and acidic steroids increased compared with those of the pair-feeding sedentary group.…”