Cholesterosis in bile duct carcinoma

Kin, Yukoh; Nimura, Yuji; Kamiya, Junichi; Kondo, Satoshi; Nagino, Masato

doi:10.1016/s0016-5107(94)70022-2

Cited by 10 publications

(7 citation statements)

References 3 publications

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“…To date, less than 40 such cases have been reported in the literature, [4–8] and our case represents the first report of CBD cholesterol polyps in a patient in China. These small lesions are often undetectable using ultrasonography, computed tomography, or MRCP, whereas endoscopic retrograde cholangiopancreatography or percutaneous transhepatic cholangiography can be helpful for diagnosis in certain patients.…”

Section: Discussionmentioning

confidence: 92%

“…[10] Cholesterol polyps are associated with the tumorigenesis of cholangiocarcinoma, in which histological analysis of the polyps has revealed distinct differences between the benign and malignant conditions. [4] Therefore, direct visual examination and histopathological analysis is essential to avoid misdiagnosis. [8] …”

Section: Discussionmentioning

confidence: 99%

“…The development of cholesterol polyps is associated with cholangiocarcinoma. [4] Therefore, choledochoscopic biopsy is essential for the histopathological diagnosis of cholesterol polyps to rule out malignancy. [1] We encountered a patient with cholesterol polyps in the distal CBD.…”

Section: Introductionmentioning

confidence: 99%

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Cholesterol polyps in the distal common bile duct

Tang

Zhao²,

Zhang³

et al. 2016

Medicine

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Rationale:Cholesterol polyps are rare in the common bile duct and difficult to diagnose.Patient concerns:The small polypoid lesions often go undetected when using routine imaging methods, such as ultrasonography.Diagnoses:We treated a patient with cholesterol polyps in the common bile duct. After failing to detect choleliths using ultrasonography, magnetic resonance cholangiopancreatography revealed mild dilation of the common bile duct. Choledochoscopy was performed during laparoscopic cholecystectomy, which revealed yellowish-white polyps circumferentially distributed across the luminal surface of the distal common bile duct. Histological examination of biopsy specimens indicated cholesterol polyps with characteristic foamy cells.Interventions:The patient was treated with ursodeoxycholic acid, and the number of polyps was found to have been reduced at the 6-week follow-up based on T-tube choledochoscopic examination.Outcomes:Recovery was unremarkable, and the ursodeoxycholic acid treatment was discontinued at the 6-month follow-up.Lessons subsections:Our findings suggest that this rare condition can be treated pharmacologically to avoid potential postsurgical complications following resection of the distal common bile duct.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Cholesterol polyps in the distal common bile duct

Tang

Zhao²,

Zhang³

et al. 2016

Medicine

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“…There have been only 25 reported cases of cholesterolosis of the bile duct (Medline and Igaku Chuo Zasshi) ( Table 2). [15][16][17][18][19][20][21][22][23] Cholesterolosis of the bile duct, as in the gallbladder, is regarded as a marker of a benign condition, and some researchers propose observation instead of surgical intervention when it is diagnosed by cholangioscopy or other means. As shown in Table 2, however, it was associated with malignancy in 15% of cases of cholesterolosis of the bile duct.…”

Section: Discussionmentioning

confidence: 99%

Choledochocele associated with superficial spreading cancer with cholesterolosis of the bile duct

et al. 2007

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A 74-year-old woman, who had suffered from acute cholangitis, was referred to our department for further evaluation of the biliary tree. A diagnosis of choledochocele was made by endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography. A small flat elevation with cholesterolosis was observed in the lower bile duct, and circumferential wall thickening was apparent in some parts of the upper and middle bile duct by intraductal ultrasonography and peroral cholangioscopy. With the diagnosis of choledochocele associated with superficial spreading cancer and cholesterolosis of the bile duct, pylorus-preserving pancreaticoduodenectomy was carried out. Microscopically, the tumor had spread extensively from the lower to the upper bile duct. Its invasion was limited to the mucosa for the most part, with microinvasion of the subserosa in the upper bile duct. In the lower bile duct, foamy cells were located beneath the neoplastic epithelium of the elevation. The number of cases of choledochocele associated with biliary cancer is becoming higher than previously reported. This anomaly may play some role in the development of biliary malignancy. Histological examination seems to be mandatory before making a diagnosis of cholesterolosis of the bile duct, since this condition may occasionally accompany cancer.

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“…Although cholesterosis is frequently observed in the gallbladder, it is very rare in the common bile duct. Since the first report by Fock in 1958, 1 only about 30 cases have been reported in the English or Japanese literature 2–6 . According to these reports, most lesions are smaller than 1 mm and are located at the distal end of the common bile duct or near the confluence with the main pancreatic duct 1–3 .…”

Section: Discussionmentioning

confidence: 99%

A Case of Cholesterosis of the Common Bile Duct Diagnosed by Peroral Cholangioscopy

Arisaka

Masuda

Yamada

et al. 2005

Digestive Endoscopy

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We experienced a case of cholesterosis of the common bile duct in which peroral cholangioscopy (POCS) was very useful for making a diagnosis. The patient was a 66‐year‐old man. He was admitted for examination of an asymptomatic mass in the pancreas. The mass was diagnosed as a serous cystic tumor of the pancreas. While examining the tumor, endoscopic retrograde cholangiopancreatography (ERCP) incidentally revealed a 7 mm irregular filling defect in the distal common bile duct. EST was then performed, followed by POCS, which revealed a clump of yellowish‐white Ip or Isp polyps in the distal bile duct. Histological examination of biopsy specimens taken under direct vision gave a diagnosis of cholesterol polyps containing foamy cells. POCS was useful for allowing direct observation of the characteristic color of cholesterol polyps, and for obtaining biopsy specimens under direct vision.

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Cholesterosis in bile duct carcinoma

Cited by 10 publications

References 3 publications

Cholesterol polyps in the distal common bile duct

Cholesterol polyps in the distal common bile duct

Choledochocele associated with superficial spreading cancer with cholesterolosis of the bile duct

A Case of Cholesterosis of the Common Bile Duct Diagnosed by Peroral Cholangioscopy

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