Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery

Miao, Wenjun; Shim, Gayong; Kang, Choong Mo; Lee, Soondong; Choe, Yearn Seong; Choi, Han‐Gon; Oh, Yu‐Kyoung

doi:10.1016/j.biomaterials.2013.08.058

Cited by 170 publications

(77 citation statements)

References 33 publications

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“…Fan et al 223 developed a water-soluble novel nanocarrier of magnetic Fe(3)O(4)-graphene nanocomposites, which showed excellent dispersibility and stability in aqueous solution and also exhibited superparamagnetic properties. Miao et al 224 fabricated cholesteryl hyaluronic acid-reduced graphene oxide (CHA-rGO) nanosheets that showed increased colloidal stability, safety, and drug-loading capacity in mice. The in vivo antitumor efficacy of DOX delivered by CHA-rGO was significantly increased compared with free DOX or DOX-loaded rGO.…”

mentioning

confidence: 99%

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Gurunathan¹,

Kim²

2016

IJN

246

140

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Graphene is a two-dimensional atomic crystal, and since its development it has been applied in many novel ways in both research and industry. Graphene possesses unique properties, and it has been used in many applications including sensors, batteries, fuel cells, supercapacitors, transistors, components of high-strength machinery, and display screens in mobile devices. In the past decade, the biomedical applications of graphene have attracted much interest. Graphene has been reported to have antibacterial, antiplatelet, and anticancer activities. Several salient features of graphene make it a potential candidate for biological and biomedical applications. The synthesis, toxicity, biocompatibility, and biomedical applications of graphene are fundamental issues that require thorough investigation in any kind of applications related to human welfare. Therefore, this review addresses the various methods available for the synthesis of graphene, with special reference to biological synthesis, and highlights the biological applications of graphene with a focus on cancer therapy, drug delivery, bio-imaging, and tissue engineering, together with a brief discussion of the challenges and future perspectives of graphene. We hope to provide a comprehensive review of the latest progress in research on graphene, from synthesis to applications.

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mentioning

confidence: 99%

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Gurunathan¹,

Kim²

2016

IJN

246

140

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“…HA has been previously reported to increase the tumor cell delivery of nanoparticles by interacting with CD44 receptors; when conjugated to ASOs, it enhances their cellular delivery [22]. Moreover, surface coating of graphene nanosheets with HA has been shown to enhance cellular delivery through CD44 receptors [23], and HA-coated nanocarriers have been designed for delivery of anticancer drug to tumors expressing CD44 receptors [24].…”

Section: Discussionmentioning

confidence: 98%

Biomimetic DNA nanoballs for oligonucleotide delivery

et al. 2015

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“…22 Cholesteryl hyaluronic acid (HA) conjugated GO loaded with doxorubicin was developed by Miao et al for targeted delivery of doxorubicin to KB epidermal carcinoma cells both in in vitro and in vivo. 23 In vitro studies showed that the targeted nanocomposite induced 40.3% increase in cell death as compared to the non-targeted one. Similarly, subcutaneous injection of the targeted nanocomposites in tumor bearing athymic mice resulted in 14.1% decrease in the tumor volume within 24 days.…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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Graphene and graphene-based nanomaterials such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene quantum dots (GQDs) have gained a lot of attention from diverse scienti¯c¯elds for applications in sensing, catalysis, nanoelectronics, material engineering, energy storage and biomedicine due to its unique structural, optical, electrical and mechanical properties. Graphene-based nanomaterials emerge as a novel class of nanomedicine for cancer therapy for several reasons. Firstly, its structural properties like high surface area and aromaticity enables easy loading of hydrophobic drugs. Secondly, presence of oxygen containing functional groups improve its physiological stability and also act as site for biofunctionalization. Thirdly, its optical absorption in the NIR region enable them to act as photoagents for photothermal and photodynamic therapies of cancer, both in vitro and in vivo. Finally, its intrinsic°u orescence property helps in bioimaging of cancer cells. Overall, graphene-based nanomaterials can act as agents for developing multifunctional theranostic platforms for carrying out more e±cient detection and treatment of cancers. This review provides a detailed summary of the di®erent applications of graphene-based nanomaterials in drug delivery, nucleic acid delivery, phototherapy, bioimaging and theranostics.

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Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery

Cited by 170 publications

References 33 publications

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Biomimetic DNA nanoballs for oligonucleotide delivery

Graphene-Based Nanomaterials for Theranostic Applications

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