Cholinergic and Adenosinergic Modulation of Synaptic Release

Yang, Danqing; Ding, Chao; Qi, Guanxiao; Feldmeyer, Dirk

doi:10.1016/j.neuroscience.2020.06.006

Cited by 16 publications

(9 citation statements)

References 196 publications

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“…All these aspects could be associated with functions in non-visual and visual areas innervated by basal forebrain and whose cholinergic activity is predominant. Such is the case of V1 where information from the basal forebrain is received through direct extrasynaptic modulation on inhibitory neurons, excitatory neurons, and on the synergic work that uses the cholinergic pathway and the N-methyl-D-aspartate receptor pathway in the process of visual plasticity 7,21,23,28,29 . Therefore, it is somehow natural to think that in diseases in which the cholinergic neuron activity of the basal forebrain drops -as it occurs with Alzheimer's disease -both the visual cortex and its actors can be affected, which can eventually lead to an inefficient visual response 30 .…”

Section: Cholinergic Systemmentioning

confidence: 99%

“…From the process of neurogenesis and synaptogenesis, both the synthesis and the activity of neurotransmitters that can be involved in cellular signaling, differentiation, immune response, and cellular migration play an important role 21,22 . This model is applicable to the development of the visual system where, in addition to the role played by growth factors like the factor derived from the brain and the nervous growth factor, among others, neurotransmitters contribute to modulating the visual signal in the early ages of development 23 .…”

Section: Cholinergic Activity In the Visual Pathwaymentioning

confidence: 99%

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Cholinergic system and the role it plays in the visual system

Durán-Cristiano¹

2022

RMOE

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The nervous system receives and processes information from the environment thanks to its constant interaction with sensory organs, including vision, a system that includes ocular structures, cortical, and subcortical areas. Consequently, some mediators can receive and transmit visual information so it can be properly processed and interpreted. Among them, the activity of chemical substances called neurotransmitters really stands out, acetylcholine (Ach) in particular since it plays a significant role. Ach acts as a neuromodulator and is involved in the biological events of the visual system that regulate visual functions such as contrast sensitivity, visual perception, and ocular functions like tear production to maintain the homeostasis of the ocular surface. This happens through the interaction of cholinergic receptors on structures of the anterior and posterior segments of the eye. Therefore, the objective of the article is to describe the different aspects that relate to cholinergic activity, the visual system, and its association with the disease.

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Section: Cholinergic Systemmentioning

confidence: 99%

Section: Cholinergic Activity In the Visual Pathwaymentioning

confidence: 99%

Cholinergic system and the role it plays in the visual system

Durán-Cristiano¹

2022

RMOE

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“…The third contribution is based on a synthesis pathway, where cADPR, generated by the enzyme ecto-NAD-glycohydrolase (CD38, ADP-ribosyl cyclase 1) via NAD + , can be converted to AMP (by ENPP1) to then be dephosphorylated to adenosine by CD73 and again, putatively, TNAP [ 112 , 113 ]. Exclusively in the nervous system, adenosine can be released via nucleoside transporters into the extracellular space [ 115 ]. This, again with the exception of the neuronal system, renders CD73 a gatekeeper of adenosine generation.…”

Section: The Molecular Role Of Tnap In Inflammation Processesmentioning

confidence: 99%

TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism

Graser

Liedtke

Jakob

2021

IJMS

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This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.

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“…Activation of the acetylcholine (Ach) muscarinic receptor potentiates NMDA glutamate receptors [ 2 ]. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity [ 3 ] and induces short-term potentiation at the synapses [ 4 , 5 ]. The muscarinic signaling affects GABAergic interneurons as well, modulating long-term potentiation (LTP) and affecting hippocampal memory process [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus

et al. 2021

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The cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysfunction of cholinergic transmission has been detected in the settings of cognitive impairment and dementia. Systemic inflammation as well as neuroinflammation has been shown to profoundly alter synaptic transmission and LTP. Indeed, intervention which is aimed at reducing neuroinflammatory changes in the brain has been associated with an improvement in cognitive functions. While cognitive impairment caused either by cholinergic dysfunction and/or by systemic inflammation suggests a possible connection between the two, so far whether systemic inflammation affects mLTP has not been extensively studied. In the present work, we explored whether an acute versus persistent systemic inflammation induced by LPS injections would differently affect the ability of hippocampal synapses to undergo mLTP. Interestingly, while a short exposure to LPS resulted in a transient deficit in mLTP expression, a longer exposure persistently impaired mLTP. We believe that these findings may be involved in cognitive dysfunctions following sepsis and possibly neuroinflammatory processes.

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Cholinergic and Adenosinergic Modulation of Synaptic Release

Cited by 16 publications

References 196 publications

Cholinergic system and the role it plays in the visual system

Cholinergic system and the role it plays in the visual system

TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism

Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus

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