Cholinergic Basal Forebrain Neurons Burst with Theta during Waking and Paradoxical Sleep

Lee, Maan‐Gee; Hassani, Oum Kaltoum; Alonso, Ángel; Jones, Barbara E.

doi:10.1523/jneurosci.0178-05.2005

Cited by 401 publications

(356 citation statements)

References 45 publications

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“…Perhaps the most important (albeit still controversial in detail) role of ACh circuits in cortex and in hippocampus is in the regulation of theta rhythm oscillatory activity (Buzsaki, 2002;Calabresi et al, 2000;Cobb and Davies, 2005;Hasselmo, 2005;Lee et al, 2005). Thetafrequency band oscillations constitute a prominent network pattern in all mammals, including humans.…”

Section: Physiology Of Ach Circuits In Pfc and Hippocampusmentioning

confidence: 99%

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Berman

Talmage

Role

2007

International Review of Neurobiology

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Central cholinergic signaling has long been associated with aspects of memory, motivation, and mood, each affected functions in neuropsychiatric disorders such as schizophrenia. In this chapter, we review evidence related to the core hypothesis that dysregulation of central cholinergic signaling contributes to the pathophysiology of schizophrenia. Although central cholinergic circuits are resistant to simplification-particularly when one tries to parse the contributions of various classes of cholinergic receptors to disease related phenomena-the potential role of ACh signaling in Schizophrenia pathophysiology deserves careful consideration for prospective therapeutics. The established role of cholinergic circuits in attentional tuning is considered along with recent work on how the patterning of cholinergic activity may modulate corticostriatal circuits affected in schizophrenia.

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Section: Physiology Of Ach Circuits In Pfc and Hippocampusmentioning

confidence: 99%

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Berman

Talmage

Role

2007

International Review of Neurobiology

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“…Previous studies led to a general notion that cholinergic MS/DB are homogeneous, exhibiting similar firing behavior as described above (Griffith and Matthews, 1986, Griffith, 1988, Markram and Segal, 1990, Griffith et al, 1991, Brazhnik and Fox, 1997, Brazhnik and Fox, 1999. However, more recent work revealed that some basal forebrain cholinergic neurons do show bursting capabilities (Lee et al, 2005). This diversity in firing properties among basal forebrain cholinergic neurons may be related to connectivity.…”

mentioning

confidence: 91%

Electrophysiological and morphological heterogeneity of slow firing neurons in medial septal/diagonal band complex as revealed by cluster analysis

Garrido-Sanabria¹,

Perez²,

Bañuelos³

et al. 2007

Neuroscience

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Slow firing septal neurons modulate hippocampal and neocortical functions. Electrophysiologically, it is unclear whether slow firing neurons belong to a homogeneous neuronal population. To address this issue, whole-cell patch recordings and neuronal reconstructions were performed on rat brain slices containing the medial septum/diagonal band complex (MS/DB). Slow firing neurons were identified by their low firing rate at threshold (< 5Hz) and lack of time-dependent inward rectification (I h ). Unsupervised cluster analysis was used to investigate whether slow firing neurons could be further classified into different subtypes. The parameters used for the cluster analysis included latency for first spike, slow afterhyperpolarizing potential, maximal frequency and action potential (AP) decay slope. Neurons were grouped into three major subtypes. The majority of neurons (55%) were grouped as cluster I. Cluster II (17% of neurons) exhibited longer latency for generation of the first action potential (246.5±20.1 ms). Cluster III (28% of neurons) exhibited higher maximal firing frequency (25.3±1.7 Hz) when compared to cluster I (12.3±0.9 Hz) and cluster II (11.8±1.1 Hz) neurons. Additionally, cluster III neurons exhibited faster action potentials at suprathreshold. Interestingly, cluster II neurons were frequently located in the medial septum whereas neurons in cluster I and III appeared scattered throughout all MS/DB regions. Sholl's analysis revealed a more complex dendritic arborization in cluster III neurons. Cluster I and II neurons exhibited characteristics of "true" slow firing neurons whereas cluster III neurons exhibited higher frequency firing patterns. Several neurons were labeled with a cholinergic marker, , and cholinergic neurons were found to be distributed among the three clusters. Our findings indicate that slow firing medial septal neurons are heterogeneous and that soma location is an important determinant of their electrophysiological properties. Thus, slow firing neurons from different septal regions have distinct functional properties, most likely related to their diverse connectivity. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroscience. Author manuscript; available in PMC 2010 January 22. Published in final edited form as:Neuroscience. (Griffith et al., 1991, Matthews and Lee, 1991, Jones et al., 1999, Morris et al., 1999, Knapp et al., 2000, Henderson et al., 2001, Sotty et al., 2003. Slow firing neurons are characterized by slow firing rates and pronounced slow post-spike afterhyperpolarization potenti...

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“…Such studies have almost exclusively focused on recording the activity of single neurons, often labelled according to cell type, and linking their firing patterns to the cortical EEG (Duque et al, 2000;Manns et al, 2000aManns et al, , 2000bHassani et al, 2009), wake/sleep regulation (Szymusiak et al, 2000;Lee et al, 2004Lee et al, , 2005, aspects of sensory stimulation (Lin and Nicolelis, 2008;Nguyen and Lin, 2014), and behavioral task performance (Thomson et al, 2014;Tingley et al, 2014Tingley et al, , 2015. Convergent evidence (Zaborszky et al, 1999;Yang et al, 2014;Xu et al, 2015) indicates that BF contains multiple interconnected and heterogeneous networks, which operate as an ensemble to modulate cortical state and play distinct roles during sleep and wakefulness.…”

Section: Introductionmentioning

confidence: 99%

Gamma band directional interactions between basal forebrain and visual cortex during wake and sleep states

Nair

Klaassen

Poirot

et al. 2016

Journal of Physiology-Paris

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The basal forebrain (BF) is an important regulator of cortical excitability and responsivity to sensory stimuli, and plays a major role in wake-sleep regulation. While the impact of BF on cortical EEG or LFP signals has been extensively documented, surprisingly little is known about LFP activity within BF. Based on bilateral recordings from rats in their home cage, we describe endogenous LFP oscillations in the BF during quiet wakefulness, rapid eye movement (REM) and slow wave sleep (SWS) states. Using coherence and Granger causality methods, we characterize directional influences between BF and visual cortex (VC) during each of these states. We observed pronounced BF gamma activity particularly during wakefulness, as well as to a lesser extent during SWS and REM. During wakefulness, this BF gamma activity exerted a directional influence on VC that was associated with cortical excitation. During SWS but not REM, there was also a robust directional gamma band influence of BF on VC. In all three states, directional influence in the gamma band was only present in BF to VC direction and tended to be regulated specifically within each brain hemisphere. Locality of gamma band LFPs to the BF was confirmed by demonstration of phase locking of local spiking activity to the gamma cycle. We report novel aspects of endogenous BF LFP oscillations and their relationship to cortical LFP signals during sleep and wakefulness. We link our findings to known aspects of GABAergic BF networks that likely underlie gamma band LFP activations, and show that the Granger causality analyses can faithfully recapitulate many known attributes of these networks.

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Cholinergic Basal Forebrain Neurons Burst with Theta during Waking and Paradoxical Sleep

Cited by 401 publications

References 45 publications

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Electrophysiological and morphological heterogeneity of slow firing neurons in medial septal/diagonal band complex as revealed by cluster analysis

Gamma band directional interactions between basal forebrain and visual cortex during wake and sleep states

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