2010
DOI: 10.1016/j.pbb.2010.01.008
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Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: Functional regulation with Vitamin D3 supplementation

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Cited by 38 publications
(18 citation statements)
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“…Cells transfected with si-InR, si-IGF-1R, or si-IGF-2R each had reduced levels of ChAT, corresponding with an earlier finding that ChAT is regulated by insulin and IGF (Soscia, Tong et al 2006). ChAT generates acetylcholine, which has an important role in cognitive and motor functions (Dineley-Miller and Patrick 1992;Deutsch, Urbano et al 2010;Peeyush, Savitha et al 2010;Pepeu and Giovannini 2010). Since inhibition of neuronal insulin, IGF-1, or IGF-2 receptors leads to deficits in ChAT expression, impairments in cognition can be attributed to CNS insulin/IGF resistance (Rivera, Goldin et al 2005; LesterColl, Rivera et al 2006;Soscia, Tong et al 2006 Lyn-Cook, Lawton et al 2009;Tong, Longato et al 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Cells transfected with si-InR, si-IGF-1R, or si-IGF-2R each had reduced levels of ChAT, corresponding with an earlier finding that ChAT is regulated by insulin and IGF (Soscia, Tong et al 2006). ChAT generates acetylcholine, which has an important role in cognitive and motor functions (Dineley-Miller and Patrick 1992;Deutsch, Urbano et al 2010;Peeyush, Savitha et al 2010;Pepeu and Giovannini 2010). Since inhibition of neuronal insulin, IGF-1, or IGF-2 receptors leads to deficits in ChAT expression, impairments in cognition can be attributed to CNS insulin/IGF resistance (Rivera, Goldin et al 2005; LesterColl, Rivera et al 2006;Soscia, Tong et al 2006 Lyn-Cook, Lawton et al 2009;Tong, Longato et al 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Speer et al [31] reported that patients with diabetes and obesity with the BB genotype of the BsmI allele in the VDR gene presented higher levels of postprandial serum C-peptide, which points to a possible role in the pathogenesis of type 2 diabetes. It has also been reported that in subjects with 25 …”
Section: Vitamin D Receptor Polymorphismsmentioning
confidence: 80%
“…To become biologically active, vitamin D needs two successive hydroxylations in the liver (at carbon 25) . This is the biologically active form of vitamin D [7] ( Fig.…”
Section: Metabolism Of Vitamin Dmentioning
confidence: 99%
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