Cholinergic/dopaminergic interaction in the rat striatum assessed from drug-induced repetitive oral movements

Beltrán, Keiko Kikuchi de; Koshikawa, Noriaki; Saigusa, Tadashi; Watanabe, Kaoru; Koshida, Yoko; Kobayashi, Masafumi

doi:10.1016/0014-2999(92)90117-m

Cited by 28 publications

(5 citation statements)

References 24 publications

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“…A similar pattern has been reported using manipulations of the cholinergic system (Kelley et al, 1989; Salamone et al, 1990; Kikuchi de Beltran et al, 1992). Microdialysis methods demonstrated that increases in extracellular levels of ACh in VLS were correlated with the jaw movements induced by tacrine and physostigmine (Cousins et al, 1999).…”

Section: The Tremulous Jaw Movement Model In Rodents: Development Andsupporting

confidence: 78%

“…Microdialysis methods demonstrated that increases in extracellular levels of ACh in VLS were correlated with the jaw movements induced by tacrine and physostigmine (Cousins et al, 1999). Cholinomimetic-induced TJMs were suppressed by local injections of muscarinic antagonists into the VLS but not into the medial striatum (Kelley et al, 1989; Salamone et al, 1990; Kikuchi de Beltran et al, 1992; Mayorga et al, 1997). Hemicholinium, which reduces ACh synthesis by blocking high affinity choline uptake, suppressed tacrine-induced jaw movements when injected into the VLS, but not into overlying cortex (Cousins et al, 1999).…”

Section: The Tremulous Jaw Movement Model In Rodents: Development Andmentioning

confidence: 99%

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Pharmacological and Physiological Characterization of the Tremulous Jaw Movement Model of Parkinsonian Tremor: Potential Insights into the Pathophysiology of Tremor

Collins-Praino¹,

Paul²,

Rychalsky³

et al. 2011

Front. Syst. Neurosci.

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Tremor is a cardinal symptom of parkinsonism, occurring early on in the disease course and affecting more than 70% of patients. Parkinsonian resting tremor occurs in a frequency range of 3–7 Hz and can be resistant to available pharmacotherapy. Despite its prevalence, and the significant decrease in quality of life associated with it, the pathophysiology of parkinsonian tremor is poorly understood. The tremulous jaw movement (TJM) model is an extensively validated rodent model of tremor. TJMs are induced by conditions that also lead to parkinsonism in humans (i.e., striatal DA depletion, DA antagonism, and cholinomimetic activity) and reversed by several antiparkinsonian drugs (i.e., DA precursors, DA agonists, anticholinergics, and adenosine A2A antagonists). TJMs occur in the same 3–7 Hz frequency range seen in parkinsonian resting tremor, a range distinct from that of dyskinesia (1–2 Hz), and postural tremor (8–14 Hz). Overall, these drug-induced TJMs share many characteristics with human parkinsonian tremor, but do not closely resemble tardive dyskinesia. The current review discusses recent advances in the validation of the TJM model, and illustrates how this model is being used to develop novel therapeutic strategies, both surgical and pharmacological, for the treatment of parkinsonian resting tremor.

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Section: The Tremulous Jaw Movement Model In Rodents: Development Andsupporting

confidence: 78%

Section: The Tremulous Jaw Movement Model In Rodents: Development Andmentioning

confidence: 99%

Pharmacological and Physiological Characterization of the Tremulous Jaw Movement Model of Parkinsonian Tremor: Potential Insights into the Pathophysiology of Tremor

Collins-Praino¹,

Paul²,

Rychalsky³

et al. 2011

Front. Syst. Neurosci.

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“…The ventral and dorsal striatum have been functionally distinguished in a number of behavioral paradigms (De Beltran et al, 1992; Wadenberg et al, 1990). On the basis of these previous observations, one might have expected to find differential effects on startle following ventral and dorsal striatal manipulations.…”

Section: Resultsmentioning

confidence: 99%

“…The ventral and dorsal striatal subregions exhibit functional differences in a variety of behavioral paradigms (De Beltran et al, 1992, 1993; Wadenberg et al, 1990). However, striatal studies pertaining to PPI have focused only on the VS.…”

Section: Experiments 1: Ppi In Rats After Lesions Of the Vs Rostrodor...mentioning

confidence: 99%

“…Although the ventral striato-pallidal modulation of PPI has been an object of intense study, regulation of PPI by the remainder of the striatal complex has not yet been fully evaluated. Previous behavioral studies have established functional differences between the VS and dorsal striatum (DS) in a variety of other paradigms (De Beltran et al, 1992; De Beltran, Koshikawa, Miwa, Kobayashi, & Stephenson, 1993; Wadenberg, Ericson, Magnusson, & Ahlenius, 1990), so one might expect to find differential effects on PPI following dorsal and ventral striatal manipulations. However, anatomical studies have shown that medium spiny neurons in the caudal portion of the DS send GABAergic projections to the caudal dorsal pallidum (Moriizumi, Nakamura, Tokuno, Kitao, & Kudo, 1988).…”

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confidence: 99%

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Prepulse inhibition in the rat is regulated by ventral and caudodorsal striato-pallidal circuitry.

Kodsi¹,

Swerdlow²

1995

Behavioral Neuroscience

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It has been shown that the acoustic startle reflex is inhibited by weak auditory prepulses presented 30-500 ms prior to the startling stimulus and that this prepulse inhibition (PPI) is modulated by ventral striato-pallidal circuitry. However, dorsal striatal modulation of PPI has not been examined. Cell-specific lesions and intracerebral drug infusions were used to elucidate striatal modulation of PPI. Quinolinic acid lesions of the ventral and caudodorsal striatum significantly decreased PPI, whereas lesions of the rostrodorsal and middorsal striatum did not significantly alter PPI. Infusion of the GABA-A antagonist picrotoxin into the ventral and caudal dorsal pallidum also significantly reduced PPI, whereas rostral pallidal picrotoxin infusion had no significant effect. Thus, PPI in the rat seems to be modulated by both ventral and caudodorsal striato-pallidal circuitry, but not by rostrodorsal or middorsal striato-pallidal projections.

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Apomorphine‐induced modulation of neural activities in the ventrolateral striatum of rats

Fujita¹,

Kato

Cui

et al. 2013

Synapse

Self Cite

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The dopaminergic system in the ventrolateral portion of the striatum (Svl), part of the basal ganglia, regulates orofacial movements; bilateral co-stimulation of both dopamine D1 -like and D2 -like receptors elicits repetitive jaw movements in rats. However, how the activities of Svl neurons are modulated by the activation of dopaminergic receptors remains unknown. We systematically injected apomorphine, a non-selective dopamine receptor agonist that induced jaw movements under urethane anesthesia, and performed multi-channel unit recording from Svl neurons. The Svl neurons were classified into two subgroups: (1) the phasically active (PA) neurons represented by mainly the medium spiny neurons and the GABAergic interneurons in part, and (2) the tonically active (TA) neurons composed of mainly the cholinergic interneurons. Apomorphine modulated PA neuron firing frequency with wide variability; 33.3% of the PA neurons were facilitated, while 38.3% were suppressed. In the majority of TA neurons, the firing frequency was reduced by apomorphine (71.1%). The cross-correlations between PA and PA, PA and TA, and TA and TA neurons were analyzed, and pairs of PA neurons and pairs of PA and TA neurons, showed negligible apomorphine-induced effect on the number of synchronized spikes. In contrast, pairs between TA neurons showed a consistent decrease in the number of synchronized spikes. The apomorphine-induced suppression of TA neuron activities with decreased synchronized outputs is likely to reduce the amount of locally released acetylcholine, which may contribute to the induction of apomorphine-induced jaw movements in rats.

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Cholinergic/dopaminergic interaction in the rat striatum assessed from drug-induced repetitive oral movements

Cited by 28 publications

References 24 publications

Pharmacological and Physiological Characterization of the Tremulous Jaw Movement Model of Parkinsonian Tremor: Potential Insights into the Pathophysiology of Tremor

Pharmacological and Physiological Characterization of the Tremulous Jaw Movement Model of Parkinsonian Tremor: Potential Insights into the Pathophysiology of Tremor

Prepulse inhibition in the rat is regulated by ventral and caudodorsal striato-pallidal circuitry.

Apomorphine‐induced modulation of neural activities in the ventrolateral striatum of rats

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