Cholinergic influence on memory facilitation induced by angiotensin II in rats

Yonkov, D; Georgiev, Vasil

doi:10.1016/0143-4179(90)90128-l

Cited by 12 publications

(1 citation statement)

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“…Galantamine significantly attenuated scopolamine-induced deficits in both learning and memory models (15). In rats studied with active and passive avoidance tasks, galantamine at 1 mg/kg but not at 0.5 mg/kg significantly improved memory retention of a learned behavior (91).…”

Section: Rodent Learning and Memorymentioning

confidence: 99%

Nicotinic Cholinergic Modulation: Galantamine as a Prototype

Woodruff-Pak

Lander²,

Geerts

2002

CNS Drug Reviews

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Nicotinic acetylcholine receptor pharmacology is becoming increasingly important in the clinical symptomatology of neurodegenerative diseases in general and of cognitive and behavioral aspects in particular. In addition, the concept of allosteric modulation of nicotinic acetylcholine receptors has become a research focus for the development of therapeutic agents. In this review the scientific evidence for changes in nicotinic acetylcholine receptors in Alzheimer's disease is described. Within this context, the pharmacology of galantamine, a recently approved drug for cognition enhancement in Alzheimer's disease, is reviewed along with preclinical studies of its efficacy on learning and memory. Galantamine modestly inhibits acetylcholinesterase and has an allosteric potentiating ligand effect at nicotinic receptors. The data collected in this review suggest that the unique combination of acetylcholinesterase inhibition and nicotinic acetylcholine receptor modulation offers potentially significant benefits over acetylcholinesterase inhibition alone in facilitating acetylcholine neurotransmission.

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Section: Rodent Learning and Memorymentioning

confidence: 99%