Cholinesterase Activity in Pregnant Women and Newborns

Biochemical and Toxicological Investigations Related to OP Compounds

“…It is lower in neonates by about 50% (de Peyster et al, 1994). Activity increases gradually and reaches adult value by the age of 1 y (Kaplan and Tildon, 1963).…”

“…During pregnancy RBC AChE activity is increased and reaches a peak during the 3rd trimester when the values are 13% higher than in non pregnant values with 87% outside the reference range for non pregnant subjects. The values return to non pregnant values by 6 weeks after pregnancy (de Peyster et al, 1994). Like the serum en2yme RBC AChE between people (interindividual variation) varies over a wide range (Sawhney andLoth, 1986, Lotti, 1995).…”

“…During pregnancy serum BuChE decreases (Howard et al, 1978). BuChE decreases throughout pregnancy and lowest values are seen at 3rd trimester when it was 19% lower than in non-pregnant women (de Peyster et al, 1994). The activity returned to non-pregnant values by the 6th week post partum.…”

“…In a recent study using acetylthiocholine as substrate plasma ChE in foetal cord blood was found to be only 16% lower than adult non pregnant females (de Peyster et al, 1994). In preterm infants there is a transient low value which rises within 2 weeks (Strausse and Modanlou, 1986).…”

Cord Blood Butyrylcholinesterase Activities in Normal Pregnant and Preeclamptic Women

“…Data produced by several investigators show that plasma cholinesterase activity declines during normal pregnancy (15)(16)(17), while others have reported that there is no change in plasma cholinesterase activity between preeclamptic and normal pregnancy (13,(18)(19)(20).…”