Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates

Sirivarasai, Jintana; Kaojarern, Sming; Yoovathaworn, Krongtong; Sura, Thanyachai

doi:10.1007/s00420-009-0422-9

Cited by 58 publications

(59 citation statements)

References 18 publications

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“…The same findings were also reported in other studies assessing the adverse effects of pesticides in workers. 2,25,26 In our study, a statistically significant association was found between the neurological symptoms reported by workers and exposure to OP and/or CB. On the other hand, although the decrease in cholinesterase activity was significantly associated with exposure to OP and/or CB, no significant association was found between pesticide-related symptoms and cholinesterase inhibition.…”

Section: Discussionsupporting

confidence: 57%

“…These results are similar to those of the study of Catano et al 27 showing a lack of significant association between health symptoms and plasma cholinesterase activity in Peruvian farm workers exposed to OP pesticides. On the other hand, Jintana et al 26 found an association between the inhibition of BChE activity and the occurrence of symptoms in the Thai agricultural population, but only during the high-exposure period.…”

Section: Discussionmentioning

confidence: 98%

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Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers

Araoud

Neffeti

Douki

et al. 2012

J Expo Sci Environ Epidemiol

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Biomonitoring of effects in agricultural workers is necessary to assess the individual risk of handling pesticides. In this study, biochemical and haematological parameters were measured to evaluate the effects of exposure to these compounds in agricultural workers. The study was carried out in 110 workers and 97 control subjects. Several haematological and biochemical parameters were analysed. Assessment of haematological parameters revealed that the mean cell volume and haematocrit levels were significantly lower in workers than in controls (P ¼ 0.002 and 0.013, respectively), while mean corpuscular haemoglobin concentrations were higher in workers (Po0.001). There was also a significant inhibition of butyrylcholinesterase activity in workers compared with that in controls (Po0.001). Assessment of biochemical parameters further showed significantly higher activities of transferases, lactate dehydrogenase (Po0.001), alkaline phosphatase (ALP) (P ¼ 0.006) and creatine kinase (CK) (Po0.015), as well as higher levels of proteins (Po0.001), creatinine (P ¼ 0.001) and urea (P ¼ 0.001) in workers compared with controls, along with significantly higher uric acid levels (P ¼ 0.012). Furthermore, the number of years exposed to pesticides predicted higher activities of alanine aminotransferase, CK, ALP, as well as uric acid levels. Overall, chronic exposure to pesticides appeared to affect several biochemical parameters. These biomarkers seem to be indicative of adverse effects of pesticides in agricultural workers, confirming their use for routine monitoring of effects.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 98%

Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers

Araoud

Neffeti

Douki

et al. 2012

J Expo Sci Environ Epidemiol

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“…Only a few persons took precautions even though they knew that the use of protective equipment can protect the body from the adverse health effects of pesticides. 9 Farmers were potentially exposed to pesticide and suffering from Parkinson disease later in life. The study found that many farmers spraying pesticide did not follow right direction.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The non-use of PPE indicated significant into higher percentage of acetyl cholinesterase (AChE) activity inhibition than those who used PPE. 9 A predictive study in Majalengka, West Java also found part of protective equipment (the non-use of long sleeve self-protective wear) and bad personal hygiene aspect (proper shower) influenced cholinesterase activity beside spraying records, smoking during spraying, records of training/extension, spraying position against wind, and age. 10 Pesticide exposure effect to cholinesterase enzyme activity using restriction among fertile women in Brebes showed a significant relation between pesticide types, working time, the use of gloves, and hand-washing behavior.…”

Section: Introductionmentioning

confidence: 99%

Effect of Personal Protective Equipment during Pesticide Application to Neurological Symptoms in Farmers in Purworejo District, Indonesia

Nurcandra

Mahkota²,

Shivalli³

2018

Kesmas: National Public Health Journal

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Agriculture is one of major sectors of Indonesia economic source with the high volume of pesticide used. Unfortunately, adverse health effect of neurotoxic pesticide has never been reported in Indonesia. This study aimed to determine effectiveness of personal protective equipment (PPE) during the use of pesticides to neurological symptoms in farmers. This study was cross-sectionally conducted from April to May 2016 in Purworejo District. About 125 farmers were selected using purposive sampling, and restriction was applied in male farmers due to the high proportion of male sprayer. Data was collected by observation and interview. Logistic regression showed protective result of PPE used during preparing (POR = 0.40; 95% CI= 0.11-1.42) and spraying (POR = 0.38; 95% CI = 0.11-1.32), also following wind direction (POR = 0.88; 95% CI = 0.27-2.87) and bathing after spraying (POR = 0.33; 95% CI = 0.04-3.01) after controlled by confounders. Proper PPE used during preparing and spraying pesticide, following wind direction during spraying, and bathing after spraying can decrease risk of neurological symptoms because of pesticide exposure. Keywords: Neurological symptoms, personal protective equipment, pesticide Abstrak Pertanian merupakan salah satu sektor utama sumber ekonomi Indonesia dengan tingginya volume pestisida yang digunakan. Sayangnya, dampak kesehatan yang buruk dari pestisida yang bersifat neurotoksik selama ini tidak pernah dilaporkan di Indonesia. Penelitian ini bertujuan untuk menganalisis efektivitas proteksi alat pelindung diri (APD) selama penggunaan pestisida terhadap gejala kelainan saraf pada petani. Penelitian ini dilakukan secara potong lintang di Purworejo selama April-Mei 2016. Sejumlah 125 petani dipilih dengan menggunakan purposive sampling dan restriksi dilakukan pada petani lakilaki karena tingginya proporsi petani laki-laki penyemprot. Data dikumpulkan dengan cara observasi dan wawancara. Regresi logistik menunjukkan efek proteksi penggunaan APD yang digunakan selama penyiapan POR = 0.40; 95% CI = 0.11-1.42) dan penyemprotan (POR = 0.382; 95% CI = 0.11-1.32), serta penyemprotan searah angin (POR = 0.88; 95% CI = 0.27-2.87) dan mandi setelah penyemprotan (POR = 0.33; 95% CI = 0.04-3.01) setelah dikontrol dengan variabel perancu. Penggunaan APD selama penyiapan dan penyemprotan pestisida, penyemprotan searah arah angin, dan mandi setelah penyemprotan dapat menurunkan risiko gejala kelainan saraf akibat pajanan pestisida. Kata kunci: Gejala kelainan saraf, proteksi alat pelindung diri, pestisida Nurcandra et al.

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“…The observed significant decrease of BChE activity was in accordance with findings of other investigators. Jintana et al (16) suggested that measuring cholinesterase activity could be an admirable biomarker for assessing pesticide exposure and health effect in exposed population. Results of his study showed that there were statistically decrease in BChE activity during high exposure period related to low exposure period.…”

Section: Discussionmentioning

confidence: 99%

Butyrylcholinesterase as Biomarker of Occupational Exposure Among Female Cotton Workers

Batool¹,

Jabeen²,

Naveed³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

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Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates

Cited by 58 publications

References 18 publications

Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers

Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers

Effect of Personal Protective Equipment during Pesticide Application to Neurological Symptoms in Farmers in Purworejo District, Indonesia

Butyrylcholinesterase as Biomarker of Occupational Exposure Among Female Cotton Workers

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