Cholorpheniramine tannate complexes: Physicochemical, chemometric, and taste masking evaluation

Rahman, Ziyaur; Zidan, Ahmed S.; Khan, Saeed R.; Reddy, Indra K.; Khan, Mansoor A.

doi:10.1016/j.ijpharm.2012.07.037

Cited by 20 publications

(6 citation statements)

References 33 publications

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“…Table shows the data for Euclidean distances between pure CPM and pure E-EPO, physical mixtures, placebo fiber, and 1:8 and 1:6 drug-loaded fibers. As anticipated, pure E-EPO and placebo fibers tested had the largest Euclidean distance, an arbitrary distance from the pure bitter drug; the higher the distance, the lower the bitterness of the sample . This was followed by the drug-loaded fibers and finally by the physical mixture.…”

Section: Results and Discussionsupporting

confidence: 59%

“…As anticipated, pure E-EPO and placebo fibers tested had the largest Euclidean distance, an arbitrary distance from the pure bitter drug; the higher the distance, the lower the bitterness of the sample. 43 This was followed by the drug-loaded fibers and finally by the physical mixture. Drug-loaded fibers had a larger distance than the physical mixture, indicating better taste-masking.…”

Section: Results and Discussionmentioning

confidence: 99%

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Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach

et al. 2019

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Electrospinning is increasingly becoming a viable means of producing drug delivery vehicles for oral delivery, particularly as issues of manufacturing scalability are being addressed. In this study, electrospinning is explored as a taste-masking manufacturing technology for bitter drugs. The taste-masking polymer Eudragit E PO (E-EPO) was electrospun, guided by a quality by design approach. Using a design of experiment, factors influencing the production of smooth fibers were investigated. Polymer concentration, solvent composition, applied voltage, flow rate, and gap distance were the parameters examined. Of these, polymer concentration was shown to be the only statistically significant factor within the ranges studied (p-value = 0.0042). As the concentration increased, smoother fibers were formed, coupled with an increase in fiber diameter. E-EPO (35% w/v) was identified as the optimum concentration for smooth fiber production. The optimized processing conditions identified were a gap distance of 175 mm, an applied voltage of between 15 and 20 kV, and a flow rate of 1 mL/h. Using this knowledge, the production optimization of electrospun E-EPO with chlorpheniramine maleate (CPM), a bitter antihistamine drug, was explored. The addition of CPM in drug loads of 1:6 up to 1:10 CPM/E-EPO yielded smooth fibers that were electrospun under conditions similar to placebo fibers. Solid-state characterization showed CPM to be molecularly dispersed in E-EPO. An electronic tasting system, or E-tongue, indicated good taste-masking performance as compared to the equivalent physical mixtures. This study therefore describes a means of producing, optimizing, and assessing the performance of electrospun taste-masked fibers as a novel approach to the formulation of CPM and potentially other bitter drug substances.

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Section: Results and Discussionsupporting

confidence: 59%

Section: Results and Discussionmentioning

confidence: 99%

Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach

et al. 2019

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“…Tannic acid belongs to the first group . This compound is commonly applied in food , as medicine , or mordant in dyeing processes . Moreover, tannic acid is used in the conservation of ferrous (iron based) metal objects without necessity of corrosion products removal from corroded surface .…”

Section: Introductionmentioning

confidence: 99%

Tannic acid as corrosion inhibitor for metals and alloys

Kuśmierek

Chrześcijańska

2013

Materials & Corrosion

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Reduction of environmental impacts caused by pollution harmful to metals and alloys is very important. The atmospheric corrosion is a serious problem due to economic and environmental losses. Thus it is important to properly prevent corrosion phenomena. Tannic acid is one of natural, non-toxic, and environment friendly inhibitors of corrosion. The inhibitive action of tannic acid was investigated using linear polarization resistance method. The corrosion parameters: corrosion potential and current as well as polarisation resistance, were determined. Corrosion rate and inhibitive efficiency was calculated for two series of tested samples (metals and alloys). An inhibitive effect of tannic acid concentration and immersion number in tannic acid solution on metal and alloys corrosion was described. Copper appeared to be the most resistant metal to corrosion in the presence of tannic acid. Higher inhibitive efficiency of tannic aid was observed in the case of Inconel 625 alloy than steel due to higher content of Cr and lower content of Fe.

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“…Salts, prodrugs, and unionized or complexed forms are all potential states that could achieve the goal, and there are very good examples of successful product development. A process involving complexation of chlorphenaramine maleate-a bitter drug-with tannic acid resulted in low solubility and effective taste masking at the pH of the mouth of 6.8, yet good dissolution and release at gastric pH [117]. Sinkula [115] described some general chemical rules to follow in designing out undesirable taste from potential prodrugs or other chemical modifications.…”

Section: Pediatric Development and Taste Maskingmentioning

confidence: 99%