Chondrogenic Predifferentiation Inhibits Vascular Endothelial Growth Factor Angiogenic Effect in Pericranium-Derived Spheroids

San‐Marina, Serban; Prummer, Christopher M.; Voss, Stephen G.; Hunter, Danielle E.; Madden, Benjamin J.; Charlesworth, M. Cristine; Ekbom, Dale C.; Janus, Jeffrey R.

doi:10.1089/ten.tea.2020.0117

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…NRP1 gene that encodes for neuropilin that are involved in nervous system development and is reported to be an important factor in the VGEF cell differentiation during angiogenesis process 23 , 24 . The transcription regulatory gene MNX1AS1 plays a vital role in methylation process during epigenetic activation and reported to contribute in gastric cancer progression 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer

Vetrivel

Nachimuthu

Abusaliya

et al. 2022

Sci Rep

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Gastric cancer is the common type of malignancy positioned at second in mortality rate causing burden worldwide with increasing treatment options. More accurate and reliable diagnostic methods/biomarkers are urgently needed. The application of transcriptomics technologies possesses the high efficiency of identifying key metabolic pathways and functional genes in cancer research. In this study, we performed a transcriptome analysis on Prunetin treated AGS cells. A total of 1,118 differentially expressed (DE) genes on Prunetin treated AGS cancer cells, among which 463 were up-regulated and 655 were down-regulated. Notably, around 40 genes were found to be related with necroptosis, among which 16 genes were found to be in close association with Receptor Interacting Protein Kinase (RIPK) family. Validation of the RIPK genes through GEPIA identified 8 genes (NRP1, MNX1, SSRP1, PRDX2, PLRG1, LGALS4, SNX5 and FXYD3) which are highly expressed in stomach cancer were significantly down-regulated in PRU treated samples. In conclusion, the sequencing data explores the expression of RIPK mediated genes through necroptosis signaling network in treating gastric cancer. The futuristic validations on the 8 genes as candidate biomarkers will offer a treatment approach against gastric cancer using PRU.

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Section: Discussionmentioning

confidence: 99%

Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer

Vetrivel

Nachimuthu

Abusaliya

et al. 2022

Sci Rep

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show abstract

“…8 For instance, poly(hydroxyethyl methacrylate) (PHEMA), poly(vinyl alcohol) (PVA), poly(ethylene glycol) (PEG), poly(ethylene glycol)-diacrylate (PEGDA), polycaprolactone (PCL), poly(acryl amide)/ poly(acrylic acid), gelatin methacryloyl (GelMA), poly(propylene fumarate) (PPF), poly(oligo ethylene glycol methacrylate) (POEGMA), and poly(N-isopropylacrylamide) (PNIPAM) are the typical synthesized materials that have been widely adopted to produce tissue-engineering hydrogels. 7,8,65,69,72,75,76,134,181 These synthetic materials are often modified macromers that present elongated degradation rates and make tissue engineering more tunable. 182,183 For example, thio-b ester-modified PEGDA hydrogels provide tunable degradation rates without changing the network of the PEGDA hydrogel.…”

Section: Synthetic Materialsmentioning

confidence: 99%

Construction of tissue-customized hydrogels from cross-linkable materials for effective tissue regeneration

et al. 2022

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Genetically modified cell spheroids for tissue engineering and regenerative medicine

Jiang

et al. 2023

Journal of Controlled Release

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Chondrogenic Predifferentiation Inhibits Vascular Endothelial Growth Factor Angiogenic Effect in Pericranium-Derived Spheroids

Cited by 3 publications

References 38 publications

Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer

Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer

Construction of tissue-customized hydrogels from cross-linkable materials for effective tissue regeneration

Genetically modified cell spheroids for tissue engineering and regenerative medicine

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