Chondroid lipoma associated with osteoclast-like multinucleated giant cells - a case report

Alyousef, Mohammed J; Nemer, Areej Al

doi:10.1111/apm.12681

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Because of the plethora of names, the true incidence of UCOGC remains unknown. Tumors with osteoclast-like giant cells have been reported in several extraskeletal sites, such as in the soft tissue, kidneys, breasts, and thyroid and parotid glands (79)(80)(81)(82)(83). Patient clinical presentation is nonspecific and similar to that of PDAC (eg, anorexia, fatigue, weight loss, and jaundice).…”

Section: Clinical Featuresmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Schawkat¹,

Manning²,

Glickman³

et al. 2020

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Pancreatic ductal adenocarcinoma (PDAC), an epithelial neoplasm derived from the pancreatic ductal tree, is the most common histologic type of pancreatic cancer and accounts for 85%-95% of all solid pancreatic tumors. As a highly lethal malignancy, it is the seventh leading cause of cancer death worldwide and is responsible for more than 300 000 deaths per year. PDAC is highly resistant to current therapies, affording patients a 5-year overall survival rate of only 7.2%. It is characterized histologically by its highly desmoplastic stroma embedding tubular and ductlike structures. On images, it typically manifests as a poorly defined hypoenhancing mass, causing ductal obstruction and vascular involvement. Little is known about the other histologic subtypes of PDAC, mainly because of their rarity and lack of specific patterns of disease manifestation. According to the World Health Organization, these variants include adenosquamous carcinoma, colloid carcinoma, hepatoid carcinoma, medullary carcinoma, signet ring cell carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, and undifferentiated carcinoma. Depending on the subtype, they can confer a better or even worse prognosis than that of conventional PDAC. Thus, awareness of the existence and differentiation of these variants on the basis of imaging and histopathologic characteristics is crucial to guide clinical decision making for optimal treatment and patient management.

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Section: Clinical Featuresmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Schawkat¹,

Manning²,

Glickman³

et al. 2020

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Chondroid lipoma: multimodality imaging in a 9-year-old female

et al. 2019

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Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis

Hamie

Abbas

Kurban

et al. 2020

The American Journal of Dermatopathology

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Osteoclast-like giant cells (OLGCs) resemble osteoclasts with their abundant cytoplasm and well-developed organelles. OLGCs are characteristic features of giant cell tumor of the tendon sheath and giant cell tumor of soft tissue but they have also been described in numerous other cutaneous conditions. The diagnostic and prognostic significance of the presence of OLGCs is unknown. Here, we summarize the clinical entities that can exhibit these cells to avoid a histological overlap, affecting diagnosis and management.

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Chondroid lipoma associated with osteoclast-like multinucleated giant cells - a case report

Cited by 4 publications

References 14 publications

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Chondroid lipoma: multimodality imaging in a 9-year-old female

Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis

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