Chondroid Metaplasia in a Fibroepithelial Polyp of Gingiva

Inflammatory Fibrous Hyperplasia Associated with Chondroid Metaplasia - Report and Morphological Analysis of Five Cases

“…The etiology of IFH is strongly associated with chronic lowgrade trauma, which can generate local inflammatory processes, being observed a higher occurrence in dental prosthesis users. Interestingly, some cases of IFH caused by ill-fitting dental prostheses may present different morphological findings, such as the presence of chondroid or osseous metaplasia in the fibrous connective tissue (Cutright, 1972;Filgueiras et al, 2016;Tenorio et al, 2016). In the present cases, it was observed that all patients were ill-fitting removable dental prostheses users, being this the etiological factor associated with the rise of the lesions.…”

“…However, the clinical history of the lesion is essential for establishing the diagnosis given chondroma and cartilaginous choristoma, contrary to the IFH associated with CM, do not present local trauma as an etiopathogenic factor. Besides that, the first one is defined as a benign neoplasm and the second consists of the presence of a cohesive and wellorganized growth of normal cells/tissue in an abnormal location, while IFH associated with CM is characterized as a reactive lesion (Tenorio et al, 2016;Bosotti et al, 2019;Dimitrijevic et al, 2019;Sethi et al, 2020).…”

“…The treatment for IFH associated with CM is total excision of the lesion since there are no reports of recurrences or post-surgical complications. Besides that, it is necessary to make a new dental prosthesis to remove the traumatic factor that causes the rise of the lesion (Filgueiras et al, 2016;Tenorio et al, 2016). In this context, it is essential to recognize the clinical andhistopathological features of IFH associated with CM to perform an accurate diagnosis and avoid excessive and inappropriate treatments.…”

“…In this way, the cells in the connective tissue may develop adipose, chondroid, or osseous metaplasia (Slack, 2007;Giroux & Rustgi, 2017). Chondroid metaplasia (CM) is uncommon in the oral cavity and, in rare instances, may be associated with IFH (Cutright, 1972;Tenorio et al, 2016). In this context, the objective of this paper is to report five cases of IFH associated with CM and to analyze morphologically the deposition of collagen in these lesions.…”

Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig

“…In contrast, in humans, chondroid tissue is thought to occur in dental masses as a result of chondroid metaplasia of pulpal or other mesenchymal tissue. 12,26 In at least one case, chondroid metaplasia occurred within inflamed pulp tissue previously damaged by a carious lesion 12 and, following experimentally induced damage, dental pulp was shown to differentiate into chondrocytes and osteocyte-like cells that produce cartilage-like matrix and bone-like matrix, respectively. 4 An odontoameloblastoma should be considered as a differential diagnosis for an odontogenic neoplasm in a guinea pig, and chondroid cementum may be present as a species-specific response.…”