Chondroitin sulfate-based nanocarriers for drug/gene delivery

Self-assembled nanoparticles based on chondroitin sulfate-deoxycholic acid conjugates for docetaxel delivery: Effect of degree of substitution of deoxycholic acid

“…Owning to the similar structure between CS and HA, CS has been reported to have the ability to recognize and interact with the HA-mediated CD44 receptor which is abundantly over-expressed on the surface of various tumor cells [17,18]. Therefore, the CS based self-assembled nanoparticles are supposed to increase tumor targeting property [19] and cellular uptake efficiency via receptor-mediated endocytosis [14]. Deoxycholic acid (DOCA), a main component of bile acid, is frequently used as the hydrophobic segment to modify the hydrophilic polymer to form stable self-assembled nanoparticles [20][21][22].…”

“…Chondroitin sulfate (CS), one type of glycosaminoglycans, consists of repeating disaccharide unites of b-1,3-linkedN-acetyl galactosamine (GalNAc) and b-1,4-linked d-glucuronicacid (GlcA) with certain sulfated position(s) [14]. As a naturally anionic mucopolysaccharide, CS exists widely in mammals' bones, cartilage, skin and blood vessels [15,16].…”

Mapping insulin non‐covalent interactions with natural polysaccharides by hydrogen/deuterium exchange mass spectrometry

“…1). In neutral pH solution, insulin mainly presents two helices located in the A-chain (AA 2-8 and AA [13][14][15][16][17][18][19][20] and one helix located in the B-chain (AA 9-19). A loop (AA 1-8), a β -turn (AA 20-23) and an extended strand (AA [24][25][26][27][28][29][30] are also present on the B-chain.…”

“…Chondroitin sulfate has been mainly used in the therapy of osteoarthritis and cartilage damage diseases but it has also applications as a component of drug delivery systems, especially in association with other excipients. [18] In recent years, the study of protein conformation and dynamics was approached through different experimental techniques, such as X-ray crystallography and high-resolution nuclear magnetic resonance, but those methods suffer inherent limitations in terms of sample amount, evaluation of production, storage or physiological conditions, especially for high molecular weight proteins. [19,20] On the other hand, mass spectrometry (MS) is a powerful technique that can be applied to protein conformational analysis.…”

Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy

“…13–15 For most types of malignancies, poor tumor accumulation presents one of the biggest hurdles to developing new therapeutics. This is especially true for pancreatic cancer (PC), where the unique tumor microenvironment prevents drug penetration and attainment of therapeutic levels within pancreatic tumors.…”