Chondroitin sulphate-guided construction of polypyrrole nanoarchitectures

Zhou, Zhengnan; Zhu, Wenjun; Liao, Jingwen; Huang, Shishu; Chen, Junqi; He, Tingli; Tan, Guoxin; Ning, Chengyun

doi:10.1016/j.msec.2014.11.070

Cited by 13 publications

(7 citation statements)

References 35 publications

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“…Restoring the physiological microenvironment of living cells provides inspiration for the design and fabrication of the desired regenerative biomaterials . The modulation of stem cell differentiation and tissue regeneration is generally achieved by physical and chemical cues imparted by the biomaterials they inhabit, and in recent years, electrical stimulation has attracted increased attention. − Micro/nanotopographies have demonstrated their capability to provide mechanical regulation of the BMSC differentiation. , It was found that three-dimensional (3D) nanostructured microarchitectures could efficiently regulate the neuronal differentiation of mesenchymal stem cells (MSCs), and three-dimensional printed scaffolds with micro/nanoporous structures could regulate the chondrogenic and osteogenic differentiation of MSCs. , Electrical stimulation has been implemented to modulate the cell behavior and fate. − Although previous studies have highlighted the effects of the physical, chemical, and electrical stimulations on the stem cells’ behavior, − those stimulations often inadequately mimic the dynamic features of the physiological microenvironment, particularly the electrical microenvironment. In particular, most studies of electrical stimulation on cell behavior contained constant static and required external power with wire connection, which may increase th erisk.…”

Section: Introductionmentioning

confidence: 99%

Polypyrrole Nanocones and Dynamic Piezoelectric Stimulation-Induced Stem Cell Osteogenic Differentiation

Zhou

Lei

et al. 2019

ACS Biomater. Sci. Eng.

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Imitating the physiological microenvironment of living cell and tissues opens new avenues of research into the application of electricity to medical therapies. In this study, dynamic piezoelectric stimulation is generated in a dynamic culture because of the piezoelectric effect of the poly(vinylidene fluoride)−polypyrrole (PVDF−PPy) electroactive composite. Combined with PPy nanocones, dynamic piezoelectric signals are effectively and continuously provided to cells. In the presence of dynamic piezoelectric stimulation and PPy nanocones, PPy-PVDF NS samples show promoted bone mesenchymal stem cell (BMSCs) adhesion, spreadin, and osteogenic differentiation. On the basis of the results of this study, PPy nanocones and dynamic piezoelectric stimulation can be administered to modulate cell behavior, paving the way for the exploration of cellular responses to dynamic electrical stimulation.

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Section: Introductionmentioning

confidence: 99%

Polypyrrole Nanocones and Dynamic Piezoelectric Stimulation-Induced Stem Cell Osteogenic Differentiation

Zhou

Lei

et al. 2019

ACS Biomater. Sci. Eng.

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“…The weaker agglomeration of SiO 2 @PPy NPs is the effect of CSA for it can play a role in constructing the grid structure in the reaction and effectively disperse the SiO 2 NPs via electrostatic interactions [20]. The CSA chains with lots of 3 International Journal of Polymer Science sulphonic (-SO 3 -) and carboxylic (-COO -) groups can interact with Py + and form intermediate complexes [24]. When the oxidative polymerization was triggered, the PPy was preferentially formed along the CSA chains [24].…”

Section: Resultsmentioning

confidence: 99%

“…The CSA chains with lots of 3 International Journal of Polymer Science sulphonic (-SO 3 -) and carboxylic (-COO -) groups can interact with Py + and form intermediate complexes [24]. When the oxidative polymerization was triggered, the PPy was preferentially formed along the CSA chains [24]. In higher CSA concentrations (≥0.3 wt%), more CSA molecules would adsorb on the surface of the SiO 2 NPs, resulting in higher steric hindrance that hinders the formation of a continuous PPy coating layer.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Hollow Carbon Nanospheres by Using Microwave Radiation

Chen

Lin

Cui

et al. 2020

International Journal of Polymer Science

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Carbon-based nanomaterials have attracted much research interest in recent years due to their excellent chemical and physiological properties such as chemical stability, low cytotoxicity, and biocompatibility. The traditional methods to prepare hollow carbon nanospheres require complicated instrumentation and harsh chemicals, including high-temperature furnace, gas inlets, and hydrogen fluoride etching. Herein, we propose a new strategy to prepare hollow carbon nanospheres in a simple and fast manner by using microwave radiation. Polypyrrole-coated silica core-shell nanoparticles (SiO2@PPy NPs) were firstly prepared and subsequently processed by microwave radiation and aqueous alkaline solution to obtain the hollow carbon nanospheres. This facile method has potent potential to be utilized in the preparation of different types of hollow carbon nanospheres with various microstructure and elemental composition.

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“…In recent years, our team has constructed various biomolecules doped PPy nanostructures [190] and verified their biocompatibility suitable for bone repair. We have electrochemically constructed different kinds of PPy nanostructures doped with chondroitin sulphate (CS) [191], polydopamine (PDA) [192], taurine (Tau) [193] or citric acid [194]. We found that the surface wettability was reversibly switched under the redox potential [195,196] and that biomolecule doped PPy improved osteogenic differentiation.…”

Section: Electroactive Polymers For Tissue Regeneration Applicationsmentioning

confidence: 99%

Electroactive polymers for tissue regeneration: Developments and perspectives

Ning

Zhou

Tan

et al. 2018

Progress in Polymer Science

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Human body motion can generate a biological electric field and a current, creating a voltage gradient of -10 to -90 mV across cell membranes. In turn, this gradient triggers cells to transmit signals that alter cell proliferation and differentiation. Several cell types, counting osteoblasts, neurons and cardiomyocytes, are relatively sensitive to electrical signal stimulation. Employment of electrical signals in modulating cell proliferation and differentiation inspires us to use the electroactive polymers to achieve electrical stimulation for repairing impaired tissues. Electroactive polymers have found numerous applications in biomedicine due to their capability in effectively delivering electrical signals to the seeded cells, such as biosensing, tissue regeneration, drug delivery, and biomedical implants. Here we will summarize the electrical characteristics of electroactive polymers, which enables them to electrically influence cellular function and behavior, including conducting polymers, piezoelectric polymers, and polyelectrolyte gels. We will also discuss the biological response to these electroactive polymers under electrical stimulation. In particular, we focus this review on their applications in regenerating different tissues, including bone, nerve, heart muscle, cartilage and skin. Additionally, we discuss the challenges in tissue regeneration applications of electroactive polymers. We conclude that electroactive polymers have a great potential as regenerative biomaterials, due to their ability to stimulate desirable outcomes in various electrically responsive cells.

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Chondroitin sulphate-guided construction of polypyrrole nanoarchitectures

Cited by 13 publications

References 35 publications

Polypyrrole Nanocones and Dynamic Piezoelectric Stimulation-Induced Stem Cell Osteogenic Differentiation

Polypyrrole Nanocones and Dynamic Piezoelectric Stimulation-Induced Stem Cell Osteogenic Differentiation

Facile Synthesis of Hollow Carbon Nanospheres by Using Microwave Radiation

Electroactive polymers for tissue regeneration: Developments and perspectives

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