Chondromyxoid Fibroma of the Orbit

Abstract

A 51-year-old woman with a history of migraine headaches was found to have an incidental right orbital mass on MRI during neurologic evaluation for headaches. The orbital mass was a well-defined, lobulated, intraosseous soft tissue lesion with circumscribed margins. Clinically, there was noted proptosis, tenderness to palpation, and slight limitation to right abduction. An orbitotomy with incisional biopsy revealed a lesion arising within the lateral orbital rim extending to the subperiosteal space. Intraoperative frozen sections indicated a low grade sarcoma, possibly metastatic. The extraosseous component was excised, and the bone was curetted until all visible tumor was removed. A diagnosis of chondromyxoid fibroma was made. The patient did well until 5 months postoperatively, when right-sided proptosis returned due to recurrent tumor. Repeat surgical resection with removal of the lateral orbital rim was performed. Histopathology was consistent with recurrent chondromyxoid fibroma.

Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review

“…CMF is most commonly found to be positive for vimentin, smooth muscle actin, desmin, S-100 (variably), and CD34. 18 Generally CMF is negative for pancytokeratin, carcinoembryonic antigen (CEA), and GFAP, and also has a low proliferation rate visualized by K i -67 staining. 19 Veras et al describe SOX9 staining in a case of sinonasal CMF.…”

Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

“…In older patients, lesions are more frequently seen at rare localizations. [16][17][18][19][20][21][22][23] In our study group, three patients were diagnosed in the fifth and one patient in the sixth decade of life. However, these lesions did not appear in atypical localizations.…”

Primary Orbital Chondromyxoid Fibroma: A Cause of Monosymptomatic Periocular Pain

“…In the case described by Ditta et al [3], a recurrence occurred after 5 months. As in the present case, the tumour had been removed by curettage.…”

“…CMF rarely occurs in the orbit. We have found 4 cases of CMF with origin in the orbital bones in the literature [2][3][4][5]. In 3 of these cases, patients presented with proptosis [2,3,5].…”