Choriocarcinoma and bilateral renal metastases

Newman, Larry B.; Morgan, Thomas E.; Bucy, James G.; Wise, Leslie

doi:10.1016/0090-4295(75)90123-5

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…To the best of our knowledge, a number of cases of choriocarcinoma metastasis in the kidneys have been reported, however, no cases of IM metastasis to the kidneys have been reported ( 19 , 20 ). In the current case, the patient presented with irregular vaginal bleeding following an induced abortion, as well as an elevated β-HCG level for >3 months.…”

Section: Discussionmentioning

confidence: 99%

An invasive mole with bilateral kidney metastases: A case report

et al. 2015

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Clinical reports of kidney metastases derived from an invasive mole (IM) are rare. The present study presents the case of a 42-year-old woman who exhibited IM and bilateral kidneys metastases in what may be, to the best of our knowledge, the first report of such a case. Following an induced abortion, the patient initially experienced irregular vaginal bleeding and subsequently presented with left-sided waist and abdominal pain. The patient was admitted to hospital and was clinically diagnosed with gestational trophoblastic neoplasia (GTN), as well as bilateral kidney metastases and a spontaneous rupture of the left kidney. This diagnosis was based on the patient's medical history, which comprised increased levels of human chorionic gonadotropin β and aberrant results on computed tomography (CT) scans. The patient subsequently received conservative management to prevent renal damage, and a standard etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine chemotherapy regimen for GTN was administered. Following eight cycles of chemotherapy, a follow-up CT examination indicated that the damage in the patient's left kidney could not be corrected with conservative treatments, therefore the left kidney was excised and a laparoscopic hysterectomy was performed. The pathological results were consistent with the clinical diagnosis and allowed further classification of the primary tumor as an IM. The present case demonstrated that it is possible for IM to metastasize to the kidney, and furthermore, that this type of metastatic tumor may be fragile and possess the potential to cause spontaneous kidney rupture.

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Section: Discussionmentioning

confidence: 99%

An invasive mole with bilateral kidney metastases: A case report

et al. 2015

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Simultaneous, contralateral hypernephroma and renal transitional cell carcinoma

McDonald

Κοnnak

1979

Urology

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Metastatic gestational trophoblastic tumour presenting as spontaneous subcapsular renal haematoma

Vijay¹,

Kaduthodil²,

Bottomley³

et al. 2008

BJR

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We describe a rare case of metastatic choriocarcinoma, which presented with acute left loin pain due to a subcapsular haematoma secondary to a bleeding renal metastasis. The renal metastasis was embolised to prevent further bleeding. To our knowledge, presentation of gestational trophoblastic tumour (GTT) with such symptoms has not been described in the recent literature. Our case illustrates that, although rare, non-gynaecological symptoms can be the first presentation of metastatic choriocarcinoma in the appropriate clinical settings. It also demonstrates that the acute bleed from a renal metastasis can be effectively managed by embolisation.

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Choriocarcinoma and bilateral renal metastases

Cited by 4 publications

References 10 publications

An invasive mole with bilateral kidney metastases: A case report

An invasive mole with bilateral kidney metastases: A case report

Simultaneous, contralateral hypernephroma and renal transitional cell carcinoma

Metastatic gestational trophoblastic tumour presenting as spontaneous subcapsular renal haematoma

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