Choriocarcinoma Metastasis in the Thyroid Gland

Erdoǧgan, GüRBüZ; Cesur, Vedia; Ünal, Muttalip; Ortaç, Fırat; Balcı, Mustafa Kemal

doi:10.1089/thy.1994.4.301

Cited by 11 publications

(5 citation statements)

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“…Although anaplastic thyroid cancer was misinterpreted in 5 patients, the malignancies of 13 of the 14 patients with cancers metastatic to the thyroid were accurately diagnosed. As shown in the previous studies, the FNAC diagnosis of secondary malignancy of the thyroid gland could have been interpreted as anaplastic cancer or highly atypical degenerative cells even years after the primary cancer was diagnosed (9,15). Using the immunohistochemical marker, vimentin, which is deemed specific for cells of mesenchymal origin, it was still difficult to differentiate anaplastic cancer from secondary malignancy.…”

Section: Discussionmentioning

confidence: 98%

Clinical and Pathological Characteristics of Secondary Thyroid Cancer

Lin¹,

Weng²,

Ho³

1998

Thyroid

110

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Although up to 24% of metastatic cancers have been reported to spread to the thyroid gland, metastases to the thyroid are not detected in clinical practice in most cases. The prognosis is poor when metastatic cancer to the thyroid occurs. The aim of this study was to examine the clinical presentation, cytopathological findings, and clinical course of secondary cancers of the thyroid. The medical records of a total of 1013 histopathologically verified thyroid cancer patients treated during the period from January 1977 to December 1995 in Chang Gung Medical Center in Linkou were analyzed retrospectively. There were 14 patients (1.4% of all thyroid cancers) with secondary cancers of the thyroid with a mean age of 55.3 +/- 16.7 years. All these patients underwent thyroid ultrasonography and a fine-needle aspiration cytology of the thyroid (FNAC) before biopsy or surgical treatment. Tissue diagnosis was obtained by biopsy or necropsy in 12 or by thyroidectomy specimens in 2 patients. Most of the patients died within 9 months of diagnosis except for 2 patients who were lost to follow-up after transferring to another hospital and 1 patient with lymphoma. Before the surgical diagnosis, there were only 7 patients who metastatic neoplasms to the thyroid gland were diagnosed by FNAC. Anaplastic thyroid carcinoma was diagnosed in 5 patients. Benign nodule was diagnosed in 1 patient and lymphoma in another patient. Most of these patients had widespread metastases to many organs, as well as the thyroid gland. As a result these patients had very short survival times. Delayed diagnosis of the thyroid metastasis was the main reason for the short survival period. In conclusion, most of the metastatic lesions presented as an advanced stage of primary cancers. FNAC was a useful tool in the diagnosis. Histopathological diagnosis by surgical open biopsy is needed for the final diagnosis.

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Section: Discussionmentioning

confidence: 98%

Clinical and Pathological Characteristics of Secondary Thyroid Cancer

Lin¹,

Weng²,

Ho³

1998

Thyroid

110

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“…26 The most common primary sites, as mentioned, was the lung, kidney, breast, gastrointestinal and ovary/ endometrial cancer. However, a wide variety of rare neoplasms may metastasize to the thyroid including choriocarcinoma 49 , nasopharyngeal carcinoma 50 , leiomyosarcoma 51 , liposarcoma 52 53 , malignant adenomyoepithelioma of the breast 44 , adrenocortical carcinoma 46 , esophagus adenocarcinoma 54 , alveolar rhabdomyosarcoma 55 , neuroendocrine tumors 56 , and mesenchymal chondrosarcoma 57 .…”

Section: Discussionmentioning

confidence: 99%

Thyroid Gland as a Target of Secondary Malignancies - an Autopsy Study and Review Data

et al. 2019

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Aim: Secondary malignancies of the thyroid gland are rarely diagnosed but their incidence at autopsy is not uncommon. Materials and methods: To investigate the clinicopathological features of patients with metastatic tumours of the thyroid gland, we reviewed autopsy records and pathological features of 36 cases with thyroidal secondary tumours from 266 cases of malignant neoplasias (excluding cases of primary thyroid cancer), over a 16-year period. Results: There were 19 men and 17 women in the study, ranging in age from 37 to 95 years (mean 70.4 years). The incidence of metastasis in thyroid gland was 0.9% in all autopsy cases, and 13.53% of the malignant tumours. The majority were carcinomas of epithelial origin. The lung was the most common primary tumour site (33.3%), followed by the breast (8.33%) and the kidney (8.33%). The most common non-epithelial malignancy was lymphoma, followed by leukaemia (total of both 25%). As for the microscopic morphological observations, diffuse infiltration pattern of tumour cells was noted in 63.89% of the cases, the formation of nodules in 33.33% of the cases and contiguous invasion in 2.79% of the cases. There were 35.71% cases of metastases associated with multinodular goitre and 28.57% cases associated with papillary microcarcinoma. Conclusion: Our study indicates that thyroid secondary malignancies are not infrequent and may constitute a diagnostic problem. Lung cancer is the most common neoplasm that metastasizes to the thyroid gland in north-western Greek population.

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“…One series of nearly 25,000 FNACs of the thyroid revealed 25 cases (0.1%) of metastases, the primary tumors were carcinomas of the kidney (8 cases), lung (7 cases), breast (5 cases), cervix uteri (1 case), colon (1 case) and 1 case each of malignant melanoma, malignant pleural mesothelioma and rhabdomyosarcoma [7]. Another series reported rare sources of primary tumors such as esophagus, stomach, skin, uterus [6], nasopharyngeal carcinoma, malignant phyloides, osteosarcoma [8], and choriocarcinoma [9]. Although the majority of the secondary tumors of the thyroid are carcinomas, there are also reported cases of sarcomas [8].…”

Section: Discussionmentioning

confidence: 99%

Prostatic Adenocarcinoma Metastasis in the Thyroid Gland

et al. 2004

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Abstract. Metastasis from prostate to thyroid gland is very uncommon. Here we report a 77-year-old man who was admitted to the hospital because of a nodular goiter. A fine-needle aspiration biopsy of the nodule showed metastatic prostatic adenocarcinoma. This is the second case of a metastatic prostate carcinoma to the thyroid gland.Key words: Thyroid metastasis, Prostatic adenocarcinoma, Fine needle aspiration cytology (Endocrine Journal 51: 445-448, 2004) OWING to its rich vascular supply, the thyroid gland is a common site of metastasis from malignant tumors elsewhere. The most common sites of origin are breast, kidney, lung, gastrointestinal tract as well as lymphoma and squamous carcinoma of the head and neck region, and melanoma [1][2][3]. Prostate cancer is the second leading cause of cancer death, after lung cancer, among males [4]. The most frequent sites of metastatic prostate carcinoma are regional lymph nodes, followed by bone, lung, bladder, liver, and adrenal gland [5]. Here, we report an unusual metastasis of prostatic carcinoma presented as a thyroid nodule. Case ReportA 77-year-old man with prostatic carcinoma was referred to our department for a nodular goiter. According to the patient's history, the nodule was present for one year and was slowly growing. Medical history revealed that prostatic adenocarcinoma (Gleason grade 4 + 5) was diagnosed after transurethral prostatectomy two years ago. Prostatic cancer located in the right lobe of the prostatic gland. Preoperative PSA level was 84.08 ng/ml (normal: 0-4 ng/ml). Combined androgen blockade (CAB) therapy consisted of gonadotrophine-releasing hormone analogue (leuprolide acetate) and bikalutamide was started. After 20 months of stable disease, PSA level rose to 127 ng/ml and lumbar vertebrae and bilateral shoulder metastases were detected. Thereafter, owing to the persistence of the patient's complaints and high PSA levels bilateral orchiectomy was performed.Clinical examination revealed a hard, palpable, painless, 2 × 1 cm nodule in the right lobe of the thyroid gland. The nodule was slightly movable on swallowing. Chest X-ray, complete blood count and serum biochemistry were normal. Thyroid-stimulating hormone (TSH), free triiodothyronine (fT 3 ), and free thyroxine (fT 4 ) were 0.42 mU/ml (normal: 0.1-4 mU/ml), 2.01 pg/ml (normal: 1.62-3.76 pg/ml), and 1.2 ng/dl (normal: 0.89-1.78 ng/dl), respectively. Thyroid autoantibodies including anti-thyroglobulin and antithyroid peroxidase were negative. Thyroid scan revealed a large "cold" nodule (Fig. 1); ultrasonographic examination showed a solid 2 × 2 cm in size nodule with a nonhomogeneous structure in the right lobe of the thyroid gland (Fig. 2).

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Choriocarcinoma Metastasis in the Thyroid Gland

Cited by 11 publications

References 1 publication

Clinical and Pathological Characteristics of Secondary Thyroid Cancer

Clinical and Pathological Characteristics of Secondary Thyroid Cancer

Thyroid Gland as a Target of Secondary Malignancies - an Autopsy Study and Review Data

Prostatic Adenocarcinoma Metastasis in the Thyroid Gland

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