Chorionic Villus Sampling and Materno-Fetal Transfusions: An Immunological Pathogenesis of Vascular Disruptive Syndromes?

Los, Frans J.; Noomen, Petra; Vermeij‐Keers, Christl; Gaillard, J. L. J.; Brandenburg, Helen; Jahoda, M. G. J.; Luider, Theo M.

doi:10.1002/(sici)1097-0223(199603)16:3<193::aid-pd827>3.0.co;2-r

Cited by 15 publications

(3 citation statements)

References 32 publications

(18 reference statements)

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“…We concluded in earlier studies that not only feto-maternal transfusion but also materno-fetal transfusion can take place after TACVS. This was demonstrated by the presence of maternal red blood cells in villous capillaries in those TACVS samples where a second attempt was needed (Los et al, 1996). Animal experiments showed that maternal serum in the fetal circulation leads to antibody mediated reaction at the level of end-arteries and capillaries resulting in apoptotic cell death leading to malformations or miscarriage (van der Zee et al, 1988(van der Zee et al, , 1997.…”

Section: Long Term Post-natal Follow-up After Transabdominal Chorion mentioning

confidence: 99%

Long term post‐natal follow‐up after transabdominal chorion villus sampling compared to amniocentesis

et al. 2005

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Section: Long Term Post-natal Follow-up After Transabdominal Chorion mentioning

confidence: 99%

Long term post‐natal follow‐up after transabdominal chorion villus sampling compared to amniocentesis

et al. 2005

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“…Although amniocentesis and chorionic villus sampling (CVS) are commonly performed, these procedures are not without risk. [1][2][3] The best known complications due to amniocentesis and CVS are preg-nancy loss and limb defects. [1][2][3] A lesser known but also frequently occurring complication after CVS is the development of hemangioma in the newborn.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] The best known complications due to amniocentesis and CVS are preg-nancy loss and limb defects. [1][2][3] A lesser known but also frequently occurring complication after CVS is the development of hemangioma in the newborn. [4][5][6][7] This is in line with the hypothesis that hemangiomas are formed due to the embolization of placental trophoblast cells.…”

Section: Introductionmentioning

confidence: 99%

Similar risk for hemangiomas after amniocentesis and transabdominal chorionic villus sampling

Bauland

Smit

Scheffers³

et al. 2012

J of Obstet and Gynaecol

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Maternoembryonic Transfusion and Congenital Malformations

1997

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There is an increasing number of reports relating chorionic villus sampling (CVS) to transverse limb reduction defects or the oromandibular limb hypogenesis complex. In addition, a correlation has been established between the severity of the defect and the gestational age when CVS is performed. Several hypotheses have been proposed for the increased incidence of congenital malformations after CVS including vascular disruption. Recently, it has been suggested that maternoembryonic transfusion can occur after CVS and that this can lead to a local antibody‐mediated reaction, followed by local pathogenetic cell degeneration, i.e., apoptotic cell death, due to vascular disruption. This increased apoptotic cell death will ultimately result in congenital malformations. This paper describes an experimental model that can explain the pathogenesis of congenital malformations after CVS. The model designed uses a whole rat embryo culture technique and intracardiac injection of antisera, mimicking transplacental transfusion after CVS. Injection of antibodies directed against blood group antigens is capable of inducing increased apoptotic cell death. Immunological staining gives evidence of involvement of antibody‐mediated reactions in the occurrence of apoptotic cell death. The dorsal aortae in 10‐day‐old rat embryos of 10‐somite stages of development consist of a continuous endothelial cell layer. The effect of intracardiac injection of antisera on the dorsal aortae is only transient. Smaller vessels such as the pharyngeal arch arteries or arteries of the limbs still have fenestrated endothelium and are therefore more vulnerable to the pathogenetic effect of the reaction after transplacental transfusion causing vascular disruption. Development of the vascular pattern and differentiation of the vascular wall reduce the risk of severe malformations later on in pregnancy, although the risk of malformations remains throughout pregnancy. Thus, intracardiac injection of antisera simulating maternoembryonic transfusion such as after CVS can lead to an antibody‐mediated reaction with vascular disruption early in pregnancy inducing apoptotic cell death. Increased cell death may ultimately result in congenital malformations, such as transverse limb defects or the oromandibular limb hypogenesis complex. © 1997 by John Wiley & Sons, Ltd.

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Chorionic Villus Sampling and Materno-Fetal Transfusions: An Immunological Pathogenesis of Vascular Disruptive Syndromes?

Cited by 15 publications

References 32 publications

Long term post‐natal follow‐up after transabdominal chorion villus sampling compared to amniocentesis

Long term post‐natal follow‐up after transabdominal chorion villus sampling compared to amniocentesis

Similar risk for hemangiomas after amniocentesis and transabdominal chorionic villus sampling

Maternoembryonic Transfusion and Congenital Malformations

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