Choroid Plexus Papillomas of Neonates, Infants and Children

Tomita, Tadanori; McLone, David G.; Flannery, Ann Marie

doi:10.1159/000120358

Cited by 49 publications

(17 citation statements)

References 26 publications

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“…In this site the CPP can arise directly from the choroid plexus of the foremen of Luschka, be a direct extension from the fourth ventricle, or through CSF dissemination. In 3.7% of cases a multifocal disease has been reported [13,47]. The incidence, 0.4% and the locations in our series are similar to the data from the literature.…”

Section: Discussionsupporting

confidence: 88%

Choroid plexus papillomas: Consideration of a surgical series of 33 cases

1996

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SummaryWith the aim of understanding better the behaviour of an uncommon lesion such as the choroid plexus papilloma, we have analysed a surgical series of 33 cases operated on at the Neurosurgical Department, University of Rome "La Sapienza", between 1955 and 1992 and have reviewed the relevant literature. Our results support the view that a radical resection of these lesions, which if removed entirely, carry a very good prognosis. The hydrocephalus should be treated only if persistent.Adjuvant treatment such as radiotherapy and chemotherapy should be reserved for specific cases.

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Section: Discussionsupporting

confidence: 88%

Choroid plexus papillomas: Consideration of a surgical series of 33 cases

1996

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“…In agreement with previously published studies, we found that choroid plexus tumors occur predominantly in the first years of life [2,3,17,18,19]. Within our cohort, 57% of children with CPP and 46.4% of those with CPC were diagnosed by the age of 2, although CPC affected children at a significantly younger mean age than CPP.…”

Section: Discussionsupporting

confidence: 92%

Choroid Plexus Tumors in Children: A Population-Based Study

et al. 2013

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Background: Choroid plexus tumors are rare neoplasms that primarily occur in children. The use of the SEER (Surveillance, Epidemiology and End Results) database allows for the analysis of the relationship between prognostic factors and survival. Methods: We analyzed the SEER database to select pediatric patients (<18 years old) with histologically confirmed diagnoses of choroid plexus papillomas (CPP; WHO Grade 0), atypical CPP (WHO Grade I) and choroid plexus carcinomas (CPC; WHO grade III). In univariate and multivariate analysis, we analyzed the relationship between demographic (age, gender, race, date of diagnosis) and treatment factors (extent of surgical resection, use of adjuvant radiation) on survival. Results: Overall, 168 pediatric subjects with choroid plexus tumors were identified as follows: 75 cases of CPP, 12 cases of atypical CPP and 81 cases of CPC. The median follow-up time was 3.5 years for CPP and 7.7 years for CPC. The median age at diagnosis was 4 years for CPP (10-90th percentile 0-16 years) and 1 year for CPC (10-90th percentile 0-10 years). In univariate regression analysis, CPC histology (β = -3.2, 95% confidence interval, CI -4.8 to -1.5, p < 0.001) was significantly associated with younger age at diagnosis in comparison to CPP. The mean tumor size was 3.7 cm for CPP and 6.0 cm for CPC (p < 0.001). A higher-grade tumor was associated with significantly increased mortality (hazard ratio, HR = 28.90, 95% CI 3.94-211.83, p = 0.001). Overall survival at 5 years was 98.7% for CPP and 58.5% for CPC (p < 0.001). Among those patients with CPC, gross total resection (GTR) was associated with a significantly lower mortality (HR = 0.21, 95% CI 0.07-0.66, p = 0.007). Overall survival at 5 years was 70.9% after GTR, significantly better than 35.9% after subtotal resection (p = 0.012) and 30% after no surgery (p = 0.003). Radiation treatment was not found to confer a survival benefit in CPC. No demographic characteristics (age, sex, race, date of diagnosis) were significantly associated with mortality. Conclusions: Analysis of a pediatric cohort of choroid plexus tumors in children in the SEER database shows that tumor grade is predictive of survival. In cases of CPC, the extent of surgical resection, especially GTR, is significantly associated with increased survival. Radiation did not confer survival benefit.

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“…It accounted for 39% of all of our plexus tumors and 35 and 29% in the Boston [3] and Washington [4] series, respectively. No cases were encountered in the Chicago report [5], This tumor usually presents at an early age although in their review. Carpenter et al [6] found that 11 of 25 patients with the tumor were 17 years of age or older.…”

Section: Discussionmentioning

confidence: 91%

Current Management of Choroid Plexus Carcinoma in Children

et al. 1991

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Eleven children with choroid plexus carcinoma are reviewed with respect to presentation, radiographic diagnosis, treatment and pathologic histology. These cases accumulated over a 33-year period and represent 39% of all of our choroid plexus tumors (n = 28). Characteristically, choroid plexus carcinomas are associated with a poor prognosis for long-term survival. Unfortunately, efforts at total resection are hindered in part by the extreme vascularity of the tumor which itself may be of considerable volume. We have recently treated four children who had biopsy or minimal resection of their tumor after which adjuvant chemotherapy was given. Chemotherapy is notcurative but it does cause a reduction in tumor volume and, more importantly, has tended to reduce the tumor vascularity. This allows for a second stage operation which is more safely performed and typically allows for more complete tumor removal. At this point, our length of follow-up is insufficient to conclude if total removal in this manner significantly increases survival but it would seem that consistent gross total removal may be an initial step toward better overall management and prognosis in this tumor type.

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Choroid Plexus Papillomas of Neonates, Infants and Children

Cited by 49 publications

References 26 publications

Choroid plexus papillomas: Consideration of a surgical series of 33 cases

Choroid plexus papillomas: Consideration of a surgical series of 33 cases

Choroid Plexus Tumors in Children: A Population-Based Study

Current Management of Choroid Plexus Carcinoma in Children

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