Choroidal and skin metastases from colorectal cancer

Abstract

Choroidal and skin metastasis of colon cancer is rare. In women, the frequency of cutaneous metastasis from colon cancer as the primary lesion in is 9% and skin metastasis occurs in 0.81% of all colorectal cancers. We report a patient with colonic adenocarcinoma who presented with visual disorder in her right eye and scalp pain as her initial symptoms. Contrast-enhance orbital magnetic resonance imaging with fat suppression revealed an infrabulbar mass, and skin biopsy of the posterior parietal scalp confirmed adenocarcinoma. These symptoms were diagnosed as being caused by choroidal and skin metastases of colonic adenocarcinoma. We started palliative chemotherapy with oral capecitabine (1000 mg/m2, twice a day, on days 1-14) every 3 wk, which was effective at shrinking the brain masses and improving the visual disorder. This is the first report that capecitabine is effective at reducing a choroidal and cutaneous metastatic lesion from right-sided colorectal cancer.

Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

“…If a cancer begins as one cell, then even a 1 mm melanoma has a malignant cell population at least in the thousands. 2 This proposal is also consistent with stem cell theory that melanomas could develop from quiescent precursor cells that have accumulated a malignant complement of mutations. 3 Any model proposed for melanomas developing from nevi, at best, can only be applied to a minority of melanomas, being fundamentally flawed for the vast majority which are known to develop de novo.…”

“…1 CM may rarely be present at the time of diagnosis of an internal malignancy. While single case reports of various cancers with cutaneous metastasis have been reported, [2][3][4][5] longitudinal retrospective or prospective studies of patients with malignancies should be undertaken to delineate malignancies commonly presenting with cutaneous metastasis and their respective clinical presentations. Our study aims to examine the clinical and morphological presentation, and histological subtypes of CM seen in a tertiary healthcare institution.…”

“…Critics have proposed that the existence of small melanomas (≤6 mm diameter) makes revision of the D criterion appropriate. 2,6 Rosendahl et al, 7 suggested that in the clinical ABCD method, the D for diameter could be appropriately substituted with D for dynamic, arguing that the arbitrary designation of a diameter greater than 6 mm to the clinical diagnosis of melanoma, as in the clinical ABCD method, is inappropriate.…”

Cutaneous metastasis: experience from a tertiary healthcare institution in Singapore

“…CM may rarely be present at the time of diagnosis of an internal malignancy. While single case reports of various cancers with cutaneous metastasis have been reported, longitudinal retrospective or prospective studies of patients with malignancies should be undertaken to delineate malignancies commonly presenting with cutaneous metastasis and their respective clinical presentations. Our study aims to examine the clinical and morphological presentation, and histological subtypes of CM seen in a tertiary healthcare institution.…”

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

“…Regarding the primary site of malignancy, gastrointestinal (GI) tract accounted for 24.4% (30/123), 2,14,16,23,30,32,33,36,46,48,49,56,61,63,64,71,78,79,83,84,88,93,96,98,101,102,105,106,115,118 breast for 17.9% (22/123) of cases, 4,6,7,10,11,13,15,[17][18][19]26,27,29,34,35,37,44,66,67 kidney for 8.1% (10/123), lung for 7.3% (9/ 123), 25,38,43,<...>…”