Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy

Abstract

Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls.
 Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SDOCT). Peripapillary choroidal thickness (PCT) was measured at 1000 and 1500 μm from Bruch's membrane opening (BMO). Subfoveal choroidal thickness (SFCT) was measured in central subfoveal area, and 500 microns apart in temporal and nasal sides. Choroidal thickness among NAION eyes, uninvolved fellow eyes, and control eyes were compared.
 Results: The mean of PCT at 1000 μm was significantly thicker in NAION and fellow eyes compared to control eyes (169.7 ± 47, 154.4 ± 42.1, and 127.7 ± 49.9 μm, respectively, P < 0.001 and P = 0.42). The mean PCT at 1500 μm was also significantly thicker in NAION and fellow eyes compared to control eyes (178.6 ± 52.8, 162.6 ± 46.1, and 135.1 ± 59 μm, respectively, P = 0.007 and P = 0.048). The mean PCT at 1000 and 1500 μm was significantly greater in NAION compared to fellow eyes (P = 0.027 and P = 0.035, respectively). The mean of SFCT was significantly thicker in NAION compared to control eyes (P = 0.032); however, there was no significant difference between uninvolved fellow and control eyes (P = 0.248).
 Conclusion: Thicker choroidal thickness in acute NAION and uninvolved fellow eyes compared to normal eyes suggests a primary choroidal role in NAION pathophysiology.

Automatic Segmentation of Choroid Layer Using Deep Learning on Spectral Domain Optical Coherence Tomography

“…However, the accuracy of depicting choroid layer declined in the extremely thick group in this study, a finding that has also been previously reported. Ophthalmologists have put focus on pathophysiology between choroid layer and various ocular diseases ranging from anterior segment (keratoconus, glaucoma) to posterior segment (AMD, PCV, optic neuropathy) [29][30][31][32][33][34]. Through the experimental thirty cases in our study, the feasibility of this Mask R-CNN model has been proved.…”

A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy

“…For supra-physiological levels of choroidal expansion, we estimated choroidal volume of 32 and 35 uL based on the choroidal thickness observed in subjects with NAION. 4 , 27 In brief, we used choroidal thicknesses that were reported at locations from 100 µm to 3000 µm starting at the scleral canal opening of eyes affected by NAION. 4 , 27 We then estimated the degree of choroidal expansion as the difference in choroidal volume between healthy subjects and subjects with NAION.…”

Evaluation of Choroid Thickness Changes After Uneventful Phacoemulsification Surgery Using Spectral Domain Optical Coherence Tomography at a Tertiary Care Eye Hospital

“…It plays an important role in various vision deteriorating diseases such as age related macular degeneration, choroidal neo-vascularization, central serous chorioretinopathy and chorioretinal atrophy in high myopia. 1,2 Choroidal thickness is determined by amount of vascularization and varies by age, sex, refractive state of eye along with any previous history of ocular trauma or surgery like cataract extraction. [3][4][5] Phacoemulsification is most common invasive intraocular surgery for removal of cataract and improves visual outcome markedly.…”