Choroidal Thickness in Chinese Children Aged 8 to 11 Years with Mild and Moderate Myopia

Abstract

Purpose To investigate macular choroidal thickness (CT), topographical variation, and associations between subfoveal choroidal thickness (SFCT) and age, gender, spherical equivalent (SE), and axial length (AL) in Chinese healthy mild and moderate myopia children aged 8 to 11 years. Methods One hundred twenty eyes from 120 healthy children were studied. Children were divided into mild and moderate myopia groups. AL and CT were evaluated. CTs were measured at the fovea, and 1 mm, 2 mm, and 3 mm nasal, temporal, superior, and inferior to the fovea. Results SFCT was 252.80 ± 46.95 µm in the whole population. AL was shorter in the mild myopia group (24.18 ± 0.69 mm) than in the moderate myopia group (24.97 ± 0.68 mm, P < 0.001), and SFCT was thicker in the mild myopia group (262.00 ± 40.57 µm) than in the moderate myopia group (236.00 ± 55.08 µm, P=0.005). The topographical variation was similar in refraction groups. CTs nasal to the fovea thinned gradually and were all significantly thinner than SFCT. CTs in the other three directions gradually thickened and peaked at locations of 2 mm to the fovea. Then, CTs thinned at 3 mm to the fovea. The thickest choroid is located temporal to the fovea. There were significant negative correlations between AL and SFCT in the mild myopia group and the whole population. No other correlations were found. Conclusions The topographical variations of choroidal thickness were similar in mild and moderate myopia groups with the thickest locations temporal to the fovea. SFCT was relatively stable in children in narrow range of age and refractive error.

Role of choroidal thickness assessment in unilateral acute anterior uveitis

“…Studies from various parts of world have evaluated different normal SFCT values for different ethnic groups like 249.6 (SD ± 36) μm in Indians[ 6 ] and 252.80 (SD ± 46.95) μm in Chinese. [ 7 ] We here observed the mean SFCT in the unaffected fellow eye to be 251 ± 66.38 μm which can be considered as the SFCT of healthy Nepalese population.…”

Comparison of choroidal thickness measurements between spectral domain optical coherence tomography and swept source optical coherence tomography in children

“…The notable difference could be attributed to the more intensive pre-school education, along with frequent near-work activities and lack of outdoor time due to crowded living places in Hong Kong compared to other regions of China 22 . Given the widely accepted postulation of the negative relationship between choroidal thickness and myopia 26 , 35 , it is conceivable that the measured choroid is thinner in our study population.…”

Choroidal Thickness and Correlations with Intraocular Pressure and Spherical Equivalent in Young Myopic Eyes without Maculopathy

“…Enhanced depth imaging optical coherence tomography (EDI-OCT) has the capacity to image the choroid in vivo with enhanced visualization of the choroidal anatomy and choroidal thickness measurement [7,8]. Using this technology, previous studies have found topographic variations of the choroid, and that CT is significantly thinner in myopic eyes than in emmetropic eyes [9][10][11][12][13]. Previous studies have also investigated the relationships between CT and other ocular or systemic variables [11,14,15].…”

“…Using this technology, previous studies have found topographic variations of the choroid, and that CT is significantly thinner in myopic eyes than in emmetropic eyes [9][10][11][12][13]. Previous studies have also investigated the relationships between CT and other ocular or systemic variables [11,14,15]. Sevaral factors, including age, refractive error and axial length (AL), have been consistently identified to be associated with CT among healthy adults.…”

“…Sevaral factors, including age, refractive error and axial length (AL), have been consistently identified to be associated with CT among healthy adults. However, the subjects in lots of these researches are adults with age in a wide range and ametropia [10,11,16], whereas youth populations without maculopathy were less investigated [17][18][19]. Knowledge on the CT among youth populations without myopic macular disease (MMD) is of great value to better understand the normal growth of myopic eyes, and also conducive to diagnosis diseases of macula and choroid, given that evaluation of the macular choroidal thickness in macular diseases is confirmed to be an indispensable part.…”