Choroidal vascularity index – a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus?

Tan, Kian-Ming; Laude, Augustinus; Yip, Vivien Cherng-Hui; Loo, Eileen; Wong, Elizabeth; Agrawal, Rupesh

doi:10.1111/aos.13044

Cited by 154 publications

(134 citation statements)

References 22 publications

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“…) Lower CVI but similar choroidal thickness was reported in eyes from diabetic patients and eyes with exudative age‐related macular degeneration (Tan et al. ; Koh et al. ; Wei et al.…”

Section: Discussionsupporting

confidence: 67%

Choroidal structural analysis and vascularity index in retinal dystrophies

Wei

Mishra

Kannan

et al. 2018

Acta Ophthalmologica

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“…) Lower CVI but similar choroidal thickness was reported in eyes from diabetic patients and eyes with exudative age‐related macular degeneration (Tan et al. ; Koh et al. ; Wei et al.…”

Section: Discussionsupporting

confidence: 67%

Choroidal structural analysis and vascularity index in retinal dystrophies

Wei

Mishra

Kannan

et al. 2018

Acta Ophthalmologica

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“…CVI but not CT, was shown to be independent from systemic and ocular factors such as age, axial length, intraocular pressure, or systolic blood pressure in a large study involving 345 normal subjects. 20 In eyes from diabetic patients and eyes with exudative AMD, there were decreased CVI with no significant change in CT. 26,28,29 CVI was also shown to provide additional information to CT in terms of longitudinal choroidal structural changes in diseases such as panuveitis 20 ; Vogt-Koyanagi-Harada (VKH) disease 25 ; central serous chorioretinopathy (CSCR) 24 ; and myopic choroidal neovascularization. 27 Changes in L/C ratio or a similar index called L/S ratio (ratio of choroidal luminal area to stromal area) were investigated and found to yield valuable information in normal physiologic conditions including diurnal variation 22 and dynamic exercise 23 as well as in a number of ocular diseases including exudative AMD 21 ; polypoidal choroidal vasculopathy (PCV) 34 ; CSCR 32,33 ; VKH disease 30,31 ; and retinitis pigmentosa.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Choroidal Vascularity Markers on Optical Coherence Tomography Using Two-Image Binarization Techniques

Wei

Sonoda

Mishra

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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METHODS. Spectral-domain OCT using enhanced-depth imaging was performed in 100 eyes from 52 normal subjects. Choroidal images were binarized to luminal area and stromal area using two different algorithms. Choroidal vascularity marker was defined as the ratio of luminal area to total choroidal area and they were termed ''luminal/choroidal area ratio (L/C ratio)'' and ''choroidal vascularity index (CVI)'' per the algorithm. The agreement between choroidal vascularity markers measured by the two techniques was compared using intraclass correlation coefficient (ICC) and Bland-Altman analysis. RESULTS.The mean values of choroidal vascularity markers were 70.12% (range, 56.76%-78.55%) for CVI and 67.44% (range, 51.09%-81.31%) for L/C ratio. Low level of absolute agreement between the two binarization techniques was reflected by an adjusted ICC of 0.353 using linear mixed model with age, sex, and spherical equivalent as covariates.CONCLUSIONS. There was discrepancy between measurements of choroidal vascularity using two commonly adopted image binarization techniques. It remained unclear what was the true choroidal vascularity and which binarization algorithm was more accurate. Future studies with enhanced image quality and improved image analysis algorithm are required to decipher the ground truth for choroidal vascularity.

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“…; Tan et al. b). Within AMD itself, choroidal thickness may change in relation to disease manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…), decreased in eyes with diabetes mellitus (Tan et al. ), higher in patients with acute central serous chorioretinopathy (Agrawal et al. ).…”

Section: Introductionmentioning

confidence: 99%

Choroidal vascular changes in age‐related macular degeneration

Koh

Agrawal

Khandelwal

et al. 2017

Acta Ophthalmologica

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There was no statistical difference in SFCT, but CVI was significantly lower in patients with AMD. Choroidal vascularity index (CVI) was also lower in 'normal fellow' AMD eyes as compared to controls. This suggests possible reduction in choroidal vascularity in eyes with AMD and also to a certain extent in the 'normal fellow' eyes without phenotypical manifestations and may suggest underlying choroidal morphological change leading to wet AMD.

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Choroidal vascularity index – a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus?

Abstract: Eyes of patients with DM showed decreased CVI with no corresponding change in choroidal thickness. Image binarization may be potentially useful as a tool to assess choroidal structures and vasculature.

Cited by 154 publications

References 22 publications

Choroidal structural analysis and vascularity index in retinal dystrophies

Choroidal structural analysis and vascularity index in retinal dystrophies

Comparison of Choroidal Vascularity Markers on Optical Coherence Tomography Using Two-Image Binarization Techniques

Choroidal vascular changes in age‐related macular degeneration

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