Choroidal Vascularity Index in Retinitis Pigmentosa: An OCT Study

Tan, Roy; Agrawal, Rupesh; Taduru, Swathi; Gupta, Arushi; Vupparaboina, Kiran Kumar; Chhablani, Jay

doi:10.3928/23258160-20180221-07

Cited by 49 publications

(30 citation statements)

References 24 publications

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“…Tan and associates evaluated the structural changes in the choroid of patients with RP and showed a significant reduction in CVI as compared to normal eyes [23]. A lower CVI in RP supports the concept that choroidal vascular defects can influence the manifestation and progression of the disease.…”

Section: In Inherited Retinal Disordersmentioning

confidence: 80%

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Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Iovino

Pellegrini

Bernabei

et al. 2020

JCM

167

128

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Remarkable improvements in optical coherence tomography (OCT) technology have resulted in highly sophisticated, noninvasive machines allowing detailed and advanced morphological evaluation of all retinal and choroidal layers. Postproduction semiautomated imaging analysis with dedicated public-domain software allows precise quantitative analysis of binarized OCT images. In this regard, the choroidal vascularity index (CVI) is emerging as a new imaging tool for the measurement and analysis of the choroidal vascular system by quantifying both luminal and stromal choroidal components. Numerous reports have been published so far regarding CVI and its potential applications in healthy eyes as well as in the evaluation and management of several chorioretinal diseases. Current literature suggests that CVI has a lesser variability and is influenced by fewer physiologic factors as compared to choroidal thickness. It can be considered a relatively stable parameter for evaluating the changes in the choroidal vasculature. In this review, the principles and the applications of this advanced imaging modality for studying and understanding the contributing role of choroid in retinal and optic nerve diseases are discussed. Potential advances that may allow the widespread adoption of this tool in the routine clinical practice are also presented.

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Section: In Inherited Retinal Disordersmentioning

confidence: 80%

“…A lower CVI in RP supports the concept that choroidal vascular defects can influence the manifestation and progression of the disease. Therefore, CVI could be used as surrogate marker in monitoring and analyzing the progression of RP [23].…”

Section: In Inherited Retinal Disordersmentioning

confidence: 99%

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Iovino

Pellegrini

Bernabei

et al. 2020

JCM

167

128

View full text Add to dashboard Cite

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“…16 The utility of CVI to evaluate choroidal vasculature was also validated in common ocular and systemic diseases. 15,[32][33][34][35][36][37][38] In this study, cigarette smoking was shown to be associated with decreased CVI and not CT. This effect may arise from decreased LA or increased SA or a combination of both in chronic smokers.…”

Section: Discussionmentioning

confidence: 91%

Choroidal Structural Changes in Smokers Measured Using Choroidal Vascularity Index

Wei

Kumar

Ding³

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Cigarette smoking is a known risk factor for vascular dysfunction. This study evaluated choroidal structural changes in smokers using the choroidal vascularity index (CVI) derived from image binarization on spectral domain optical coherence tomography scans with enhanced depth imaging (EDI-OCT). METHODS. This cross-sectional study included 39 smokers and 44 non-smokers. Choroidal images on EDI-OCT were binarized into luminal area (LA) and stromal area (LA). CVI was calculated as the ratio of LA to total choroid area (TCA). CVI, foveal retinal thickness (FRT), and subfoveal choroidal thickness (SFCT) between smokers and non-smokers were compared using likelihood ratio test with linear mixed model. Trend and subgroup analysis were performed to investigate the dose-dependent relationship between CVI/FRT/SFCT and packyears. RESULTS. CVI in smokers (65 6 2%) was lower compared to non-smokers (67 6 2%, P ¼ 0.0001). The difference remained significant after adjusting for age (P ¼ 0.001). There was no significant association between cigarette smoking and FRT/SFCT. CVI decreased by 0.12% with each unit increase in smoking measured by pack-year (P ¼ 0.0009). In subgroup analysis, those who smoked 8 to 12 and >12 pack-years had significantly lower CVI compared to non-smokers (both P < 0.05). CONCLUSIONS. Cigarette smoking is associated with decreased choroidal vascularity in healthy subjects, and this association appears to be dose dependent. CVI might be a non-invasive marker of vascular health in smokers.

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“…Agrawal et al 15 found that CVI increased in both acute CSC eyes and fellow eyes. Tan et al 26 reported that patients with retinitis pigmentosa showed reduced CVI when compared with normal eyes. Thus CVI has evolved into a noninvasive tool for studying structural changes in the choroid and monitoring retinal and choroidal diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Choroid in Women with Uncomplicated Pregnancy

Taweebanjongsin

Gaw

et al. 2020

Trans. Vis. Sci. Tech.

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To study the choroid in uncomplicated pregnant women using advanced optical coherence tomography (OCT) imaging and analysis. Methods: Women with uncomplicated pregnancy in the third trimester (>28 weeks gestational age) and age-matched nonpregnant women were enrolled in this prospective study. All subjects underwent spectral-domain OCT with enhanced depth imaging mode and spectral-domain optical coherent tomography angiography (OCTA). Main outcomes were subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), and choriocapillaris flow deficits (CC FD). Results: Twenty-two eyes of 12 uncomplicated pregnant women and 23 eyes of 15 nonpregnant, female controls were included. The mean age was 32.27 ± 6.96 years for the pregnant group and 30.08 ± 5.49 years for control group (P > 0.05). Mean SFCT was 238.70 ± 82.96 μm in the pregnant group, and 277.40 ± 61.79 μm in the control group. CVI was 67.58% ± 2.45% in the pregnant group and 67.31% ± 2.62% in the control group. The CC FD% was 54.06 ± 3.95 in the pregnant group, and 55.02 ± 3.78 in the control group. There was no significant difference between the pregnant and control groups (P > 0.05) in SFCT, CVI or CC FD. Conclusions: Although extensive hemodynamic changes occurred with pregnancy, choroidal measurements by OCT and OCTA demonstrated no differences in uncomplicated third-trimester pregnant women compared with nonpregnant controls. Translational Relevance: The unaltered choroid in uncomplicated third-trimester pregnancy we described allows clinicians to determine whether abnormal choroidal measurements could be used as a biomarker for complications of pregnancy.

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Choroidal Vascularity Index in Retinitis Pigmentosa: An OCT Study

Abstract: Patients with RP showed a significant reduction in CVI and an increase in CT as compared to normal eyes. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:191-197.].

Cited by 49 publications

References 24 publications

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Choroidal Structural Changes in Smokers Measured Using Choroidal Vascularity Index

Evaluation of the Choroid in Women with Uncomplicated Pregnancy

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