CHRNA2: a new paradigm in beige thermoregulation and metabolism

Ma, Yingxu; Liu, S.; Jun, Hee-Jin; Wu, Jun

doi:10.1016/j.tcb.2021.11.009

Cited by 6 publications

(2 citation statements)

References 93 publications

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“…Metabolic interventions based on the application of a single engineered beige adipocyte may be too shortlived. Further efforts are needed to understand what would promote longer maintenance of this metabolically active depot and whether modifications that could create a microenvironment capable of promoting self-renewal of engineered beige adipocytes, enhanced beige adipogenesis, or metabolic activity after transplantation (Bai et al, 2016;Ma et al, 2022). The use of stem cell induction, gene editing techniques, cellular reprogramming, small molecule or hybrid biomaterials, and other techniques to promote weight loss and metabolic improvement by using beige adipocytes is an important step.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Engineered Beige Adipocytes in Metabolic Diseases

Liao

Cai

2023

Preprint

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We sought to characterize the effects of engineered beige fat on metabolic diseases by reviewing its history, examining experimental data, exploring putative mechanisms of action, and predicting its therapeutic future.White adipocytes are highly adaptable and can transform into beige adipocytes with thermogenic capacity, which have beneficial effects in treating metabolic diseases. However, access to beige adipocytes is limited, and treatment efficacy decreases over time. Thus, new approaches are needed to enhance the adaptive thermogenic capacity of beige adipocytes. The investigation revealed that engineered techniques, such as induction of stem cell regeneration, adipocyte gene editing, and adipocyte reprogramming techniques, can generate beige adipose tissue via autologous cell induction, adipose tissue remodeling, and functional biomaterials. Engrafted engineered beige adipocytes can generate large amounts of UCP1-positive adipose tissue in patients with metabolic diseases, paving the way for developing metabolically active beige adipose tissue and expanding its functionality in metabolic therapy. Understanding how engineered beige fats treat metabolic diseases will aid in disease prevention and treatment. These sophisticated tissue engineering systems offer new avenues for generating functional beige adipose tissue in patients with metabolic diseases.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Engineered Beige Adipocytes in Metabolic Diseases

Liao

Cai

2023

Preprint

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“…An adipose non-neuronal cholinergic circuitry was recently uncovered through exploring unique signaling pathways that regulate beige fat function [40,41,81,82]. A global transcriptional profiling approach was used to search for factors with an enriched expression pattern in activated beige adipocytes, from which a subunit of the nicotinic acetylcholine receptor (nAChR)cholinergic receptor nicotinic alpha 2 subunit (CHRNA2)was identified.…”

Section: Chams: a Unique Subpopulation Of Macrophages In Beige Thermo...mentioning

confidence: 99%