Chromatin Remodeling in Carcinoma Cells

Becker, Therese M.

doi:10.1002/3527600906.mcb.201100031

Cited by 2 publications

(1 citation statement)

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“…As mentioned above (section 3) these regions are visible as microscopical "senescence associated heterochromatin foci" (SAHF) when cells are stained with certain DNA intercalating dyes such as DAPI. The term heterochromatin refers to a highly condensed protein-DNA structure, which is facilitated by modifications of the histone core molecules of chromatin and suppresses DNA access by the transcriptional machinery and thus gene expression of these regions is tightly suppressed (reviewed in [129]). The investigation of SAHF remains a progressing research field and is developing forward with improved microscopic imaging technology and the ability to isolate these complex structures and analyse them more precisely and we can expect to understand even more about their role and configuration in the future.…”

Section: Prb and Sahfsmentioning

confidence: 99%

Molecular Mechanisms of Cellular Senescence

Becker¹,

Haferkamp²

2013

Senescence and Senescence-Related Disorders

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Section: Prb and Sahfsmentioning

confidence: 99%

Molecular Mechanisms of Cellular Senescence

Becker¹,

Haferkamp²

2013

Senescence and Senescence-Related Disorders

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Senescence and Senescence-Related Disorders

Wang¹,

Inuzuka²

2013

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The last chapter is by Dr. Claudio Franceschi and colleagues. They describe how to combat neurodegenerative disease using results obtained with ad hoc models such as centenarians and their offspring compared with subjects affected by Down syndrome. They also discuss future perspectives on the reversibility of early stages of degenerative diseases by non antiinflammatory approaches including physical exercise, motivational implementation, nutrition and nutraceutic approaches. Importantly, they conclude the development of novel tools to be integrated in daily life of elderly people which is critical for reducing degenerative diseases. Lastly, as the editors, we are grateful to the contributors for their promptness in preparing their chapters. We are also impressed by their dedication and diligent work. We are thankful to Dr. Wenyi Wei for strong support during publishing this book. We also appreciate receiving help from Ms. Danijela Duric.

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Chromatin Remodeling in Carcinoma Cells

Cited by 2 publications

References 176 publications

Molecular Mechanisms of Cellular Senescence

Molecular Mechanisms of Cellular Senescence

Senescence and Senescence-Related Disorders

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