Chromatographic separations of aromatic carboxylic acids

Waksmundzka‐Hajnos, Monika

doi:10.1016/s0378-4347(98)00257-6

Cited by 72 publications

(35 citation statements)

References 161 publications

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“…The results indicate that carboxylic acid containing compounds should not be analyzed using ion-pairing liquid chromatography; instead, reversephase liquid chromatography using acidic mobile phases is appropriate, as demonstrated previously [12,17].…”

Section: Optimization Of Lc-ms Conditionssupporting

confidence: 51%

Development of generic liquid chromatography-mass spectrometry methods using experimental design

Seto

Bateman

Gunter

2002

J. Am. Soc. Mass Spectrom.

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Section: Optimization Of Lc-ms Conditionssupporting

confidence: 51%

Development of generic liquid chromatography-mass spectrometry methods using experimental design

Seto

Bateman

Gunter

2002

J. Am. Soc. Mass Spectrom.

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“…Ion-pair chromatography is versatile and offers more possibilities for changing the stationary and/or mobile phase parameters. 27 WaksmundzkaHajons 28 and Cecchi 29 have discussed the retention mechanism of ion-pair chromatography in detail. It was shown that the addition of C7 -C9 alkylsulfonates to a mobile phase at concentrations over the range of ∼1 -10 mM can provide the separation of compounds having amino groups.…”

Section: Factors Affecting Separationmentioning

confidence: 99%

Simultaneous Determination of Trigonelline, Caffeine, Chlorogenic Acid and Their Related Compounds in Instant Coffee Samples by HPLC Using an Acidic Mobile Phase Containing Octanesulfonate

Arai¹,

Terashima²,

Aizawa

et al. 2015

ANAL. SCI.

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“…Reversed-phase HPLC (RP-HPLC) in particular, has proven to be very versatile in its ability to simultaneously analyze small molecular weight compounds of different polarities [60][61][62][63]. However, the cationic nature of weak basic drugs such as tricyclic antidepressants and bronchodilators produces broad asymmetrical peaks when analyzed by RP-HPLC or CEC with aqueous-organic solutions as a mobile phase, and C18 columns (containing high amount of residual or free silanol groups) as stationary phases [64,65].…”

Section: Determination Of Basic Drugs By Hplcmentioning

confidence: 99%

Characterization of pharmaceutical drugs by a modified nonaqueous capillary electrophoresis – mass spectrometry method

et al. 2003

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A simple method for the separation and characterization of a group of nine basic compounds, comprising seven tricyclic antidepressant and two bronchodilator drugs, by nonaqueous capillary electrophoresis (NACE) employing ultraviolet and mass spectrometry detection is described. After optimization of the electrophoresis separation conditions, including the compositions of the electrolyte and the organic solvent, a reliable separation of all nine basic analytes was achieved in 80 mM ammonium formate dissolved in a methanol-acetonitrite (80:20 v/v) mixture, having an apparent pH of 8.7. The volatile nonaqueous electrolyte system used with a normal electroosmotic flow polarity also provided an optimal separation condition for the characterization of the analytes by mass spectrometry. When results were compared with reversed-phase gradient and isocratic high-performance liquid chromatography (HPLC) methods, the NACE method provided greater efficiency, achieving baseline resolution for all nine basic compounds in less than 30 min. The NACE method is suitable for use as a routine procedure for the rapid separation and characterization of basic compounds and is a viable alternative to HPLC for the separation of a wide range of pharmaceutical drugs.

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Chromatographic separations of aromatic carboxylic acids

Cited by 72 publications

References 161 publications

Development of generic liquid chromatography-mass spectrometry methods using experimental design

Development of generic liquid chromatography-mass spectrometry methods using experimental design

Simultaneous Determination of Trigonelline, Caffeine, Chlorogenic Acid and Their Related Compounds in Instant Coffee Samples by HPLC Using an Acidic Mobile Phase Containing Octanesulfonate

Characterization of pharmaceutical drugs by a modified nonaqueous capillary electrophoresis – mass spectrometry method

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