Chromatolysis in the superior cervical ganglion of the cat

Bianchine, Joseph R.; Levy, Leonard W.; Farah, A.

doi:10.1016/0014-4800(64)90046-2

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Nissl bodies were decreased in number and the peripheral cytoplasm of the neuron was often devoid of Nissl bodies (peripheral chromatolysis). The remaining Nissl bodies in the large pale neurons were concentrated around the nucleus and frequently seemed to be attached to the nuclear membrane, a feature known as a nuclear rim or cap (Bianchine et al, 1964;Bodian, 1964;Lieberman, 1971). Under low magnification, this gave the impression of a thickening of the nuclear membrane.…”

Section: Resultsmentioning

confidence: 95%

“…It is the classical neuronal response to axotomy, and it also occurs after some toxic injuries to neurons (acrylamide, actinomycin, alcohol, 6-aminonicotinamide, capsaicin, triethyltin, trimethyltin, toxic lectins, etc.). In contrast, peripheral chromatolysis is thought to be much less common but it has been reported after axotomy in certain species (Bianchine et al, 1964;Cammermeyer, 1963aCammermeyer, , 1963bCammermeyer, , 1969Lieberman, 1971) and after ischemia in certain species (Fercakova et al, 1984(Fercakova et al, , 1986Petito and Pulsinelli, 1984;Zigova et al, 1985). Displacement of the nucleus from the center of the neuron is a cardinal feature of classical central chromatolysis but it has also been noted in all of the publications cited above on peripheral chromatolysis.…”

Section: Introductionmentioning

confidence: 85%

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A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium

Levine

Saltzman

Kumar

2004

Journal of Neuroscience Methods

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 85%

A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium

Levine

Saltzman

Kumar

2004

Journal of Neuroscience Methods

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“…Significantly, close lesions also evoke a more vigorous regenerative response A. GLOSTER AND J. DIAMOND than do distal lesions, both in the peripheral nervous system (Lieberman, 1974) and in the central nervous system (CNS) (Aguayo et al, 1991). Cutting (Bianchine et al, 1964;Matthew and Raisman, 1972) or crushing (Purves and Nja, 1978) of the postganglionic nerve initiates a vigorous CBR in the SCG, and cutting the internal carotid branch of the SCG close to the ganglion induces a larger increase in T a l a-tubulin expression than does the cutting of the branch close to the eye (Mathew and Miller, 1991). In contrast to these studies of the effects of mechanical lesions, that produced by 6-OHDA represent an axonal injury located at the most extreme distance from the cell body (Tranzer and Thoenen, 1968;Tranzer et al, 1969;de Champlain, 1970); not surprisingly this distal lesion elicits none of the ultrastructural alterations that characterize the CBR (Tranzer et al, 1969;Angeletti and Levi-Montalcini, 1970;Bjerre et al, 1974).…”

Section: Near Versus Far Phenomenamentioning

confidence: 98%

NGF‐dependent and NGF‐independent recovery of sympathetic function after chemical sympathectomy with 6‐hydroxydopamine

Gloster

Diamond

1995

J of Comparative Neurology

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To help clarify the distinction between the nerve growth factor (NGF)-dependent collateral sprouting of sympathetic nerves and their NGF-independent regeneration after crush, we used 6-hydroxydopamine (OHDA) to destroy the sympathetic terminals in adult rats; this leaves the axons damage-free. Would recovery occur by regeneration and/or collateral sprouting? A single 6-OHDA injection abolished the sympathetic pilomotor field revealed by electrical stimulation of a cutaneous nerve. Recovery began within 2 days, and by 20 days the field was reestablished. If the field was "isolated" by adjacent denervations at the time of 6-OHDA treatment, the recovering pilomotor field expanded extensively into the surrounding territory. In the presence of anti-NGF, however, the pilomotor field expansion ceased at about 60% of its former size; if anti-NGF treatment was discontinued, expansion recommended and extended into the surrounding skin. We suggest that the latter, NGF-dependent, growth phase corresponds to collateral sprouting, and the initial NGF-independent one to regeneration. After simple nerve crush, however, such regeneration can triple the normal sympathetic field size. This difference between crush- and 6-OHDA-induced regeneration might relate to the "cell body reaction" (CBR); the CBR is reduced with increasing distance of the lesion and is undetectable after a 6-OHDA lesion. Since the CBR and the vigor of regeneration are both increased by repeated axonal injury, we tested the effects of multiple 6-OHDA treatments; this significantly increased the initial NGF-independent expansion. We hypothesize that regeneration is regulated largely by mechanisms associated with the CBR, and that neurotrophin-dependent collateral sprouting occurs independently of these.

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Morphometric measurements and RNA content of axotomized feline cervical motoneurons

et al. 1982

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Microspectrophotometric estimates of RNA content and morphometric measurements of cytoplasmic, nuclear and nucleolar areas were made on 30 to 60 motoneurons (somal areas greater than 1000 microns2) ipsilateral and contralateral to brachial plexotomy performed unilaterally on adult cats 2-90 days before sacrifice. Nerve cells of unoperated animals were also assayed. Somal and cytoplasmic areas of axotomized motoneurons were larger than those of the corresponding, contralateral motor nerve cells 4, 6 and 75 days postoperatively. Because of between animal variability, it could not be determined, however, whether this difference was due to an increase in the area of the axotomized motoneurons or to a decrease in the area of the contralateral nerve cells. Nucleolar sizes did not change. In contrast, nuclei of axotomized motoneurons showed a temporary but unequivocal areal decrease. The cytoplasmic RNA content of axotomized motoneurons fell 14-28 days postoperatively but rose thereafter, being increased slightly but significantly 75-90 days after operation. At no postoperative interval, however, did the nucleolar RNA content of the axotomized cells deviate unequivocally from the unoperated or zero day condition. The following points may be emphasized: 1. these results differ from similar measurements of axotomized motoneurons of rodents and lagomorphs; 2. the data do not provide certain evidence of change in either morphometric parameters or RNA content of motoneurons on the side contralateral to surgery, although the possibility of a decrease in the size of these uninjured neurons should be considered; 3. morphometric and RNA measurements on axotomized peripheral (extrinsic) neurons of spinal anterior horn of cat contrast with similar measurements on axotomized central (intrinsic) neurons of cat red nucleus.

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Chromatolysis in the superior cervical ganglion of the cat

Cited by 7 publications

References 22 publications

A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium

A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium

NGF‐dependent and NGF‐independent recovery of sympathetic function after chemical sympathectomy with 6‐hydroxydopamine

Morphometric measurements and RNA content of axotomized feline cervical motoneurons

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